Posaconazole (Intravenous)

Generic name: Posaconazole
Drug class: Azole antifungals

Usage of Posaconazole (Intravenous)

Posaconazole injection is used to prevent certain fungus (yeast) infections (eg, invasive Aspergillus or Candida infections) in patients who have a weakened immune system (eg, hematopoietic stem cell transplant or HSCT recipients, or patients with blood cancers).

Posaconazole injection is also used to treat invasive aspergillosis.

This medicine is to be given only by or under the direct supervision of a doctor.

Posaconazole (Intravenous) side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Black, tarry stools

bleeding gums

blood in the urine or stools

blurred vision

decreased urine

dizziness

fever or chills

headache

increased thirst

irregular heartbeat

loss of appetite

mood or mental changes

muscle pain, cramps, spasms, or twitching

nausea or vomiting

nervousness

numbness or tingling in the hands, feet, or lips

pale skin

pinpoint red spots on the skin

pounding in the ears

slow or fast heartbeat

swelling of the hands, ankles, feet, or lower legs

trembling

trouble breathing

unusual bleeding or bruising

unusual tiredness or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Cough

diarrhea

difficulty having a bowel movement (stool)

rash

small red or purple spots on the skin

upper stomach pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Posaconazole (Intravenous)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of posaconazole injection in children younger than 2 years of age to prevent fungus infections. Safety and efficacy have not been established.

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of posaconazole injection in children 13 years of age and older to treat invasive aspergillosis. Safety and efficacy have been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of posaconazole injection in the elderly.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Alfuzosin

Alprazolam

Amiodarone

Aripiprazole

Astemizole

Atorvastatin

Bedaquiline

Bepridil

Buprenorphine

Cisapride

Citalopram

Clarithromycin

Clozapine

Colchicine

Conivaptan

Crizotinib

Dabrafenib

Dasatinib

Dihydroergotamine

Disopyramide

Dofetilide

Domperidone

Donepezil

Dronedarone

Eletriptan

Eliglustat

Encorafenib

Entrectinib

Eplerenone

Ergonovine

Ergotamine

Erythromycin

Etrasimod

Fexinidazole

Finerenone

Flibanserin

Fluvastatin

Fostemsavir

Gepirone

Glasdegib

Halofantrine

Haloperidol

Iloperidone

Isavuconazonium Sulfate

Itraconazole

Ivabradine

Ivosidenib

Lapatinib

Levoketoconazole

Lomitapide

Lopinavir

Lovastatin

Lumefantrine

Lurasidone

Macimorelin

Maraviroc

Mavacamten

Mefloquine

Mesoridazine

Methadone

Methylergonovine

Methysergide

Mifepristone

Mirtazapine

Mobocertinib

Naloxegol

Nelfinavir

Nilotinib

Nimodipine

Ondansetron

Osilodrostat

Pacritinib

Pazopanib

Pimozide

Piperaquine

Propafenone

Quetiapine

Quinidine

Quinine

Ranolazine

Relugolix

Ribociclib

Saquinavir

Selpercatinib

Simvastatin

Sirolimus

Solifenacin

Sorafenib

Sparfloxacin

Sunitinib

Tacrolimus

Tamoxifen

Telithromycin

Terfenadine

Thioridazine

Tolvaptan

Toremifene

Trazodone

Ubrogepant

Vardenafil

Vemurafenib

Venetoclax

Vilanterol

Voclosporin

Voriconazole

Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acalabrutinib

Adagrasib

Ado-Trastuzumab Emtansine

Alfentanil

Amitriptyline

Amprenavir

Anagrelide

Apalutamide

Apixaban

Apomorphine

Aprepitant

Arsenic Trioxide

Asenapine

Atogepant

Avacopan

Avanafil

Avapritinib

Axitinib

Azithromycin

Benzhydrocodone

Bosutinib

Brentuximab Vedotin

Brexpiprazole

Brigatinib

Bromocriptine

Budesonide

Buserelin

Ceritinib

Chloroquine

Chlorpromazine

Cilostazol

Cimetidine

Ciprofloxacin

Clofazimine

Clomipramine

Clothiapine

Cobimetinib

Codeine

Copanlisib

Cyclobenzaprine

Cyclosporine

Daclatasvir

Daridorexant

Deflazacort

Degarelix

Delamanid

Desipramine

Deslorelin

Deutetrabenazine

Dexamethasone

Dexmedetomidine

Dihydrocodeine

Docetaxel

Dolasetron

Doxepin

Doxorubicin

Doxorubicin Hydrochloride Liposome

Droperidol

Duvelisib

Ebastine

Efavirenz

Elacestrant

Elagolix

Elexacaftor

Enzalutamide

Eribulin

Erlotinib

Escitalopram

Esomeprazole

Eszopiclone

Etravirine

Everolimus

Famotidine

Fedratinib

Felbamate

Fentanyl

Fesoterodine

Fingolimod

Flecainide

Fluconazole

Fluoxetine

Fluticasone

Formoterol

Fosamprenavir

Fosaprepitant

Foscarnet

Fosphenytoin

Galantamine

Gatifloxacin

Gemifloxacin

Gilteritinib

Gonadorelin

Goserelin

Granisetron

Histrelin

Hydrocodone

Hydroquinidine

Hydroxychloroquine

Hydroxyzine

Ibrexafungerp

Ibrutinib

Ibutilide

Idelalisib

Ifosfamide

Imipramine

Infigratinib

Inotuzumab Ozogamicin

Irinotecan

Irinotecan Liposome

Istradefylline

Ivacaftor

Ixabepilone

Larotrectinib

Lefamulin

Lemborexant

Leniolisib

Lenvatinib

Leuprolide

Levofloxacin

Levomilnacipran

Lofexidine

Lorlatinib

Lumacaftor

Lumateperone

Lurbinectedin

Macitentan

Manidipine

Meperidine

Methotrexate

Methotrimeprazine

Metronidazole

Midazolam

Midostaurin

Mirvetuximab Soravtansine-gynx

Mitapivat

Mizolastine

Moricizine

Moxifloxacin

Nafarelin

Neratinib

Nifedipine

Norfloxacin

Octreotide

Ofloxacin

Olanzapine

Olaparib

Omaveloxolone

Osimertinib

Oxaliplatin

Oxycodone

Ozanimod

Palbociclib

Paliperidone

Palovarotene

Panobinostat

Papaverine

Paroxetine

Pasireotide

Pemigatinib

Pentamidine

Pentazocine

Perphenazine

Pexidartinib

Phenobarbital

Phenytoin

Pimavanserin

Pipamperone

Pirtobrutinib

Pitolisant

Ponatinib

Ponesimod

Pralsetinib

Primidone

Probucol

Procainamide

Prochlorperazine

Promethazine

Protriptyline

Quizartinib

Reboxetine

Regorafenib

Retapamulin

Rifabutin

Rifampin

Rimegepant

Risperidone

Ritonavir

Rivaroxaban

Romidepsin

Ruxolitinib

Salmeterol

Selumetinib

Sertindole

Sertraline

Sevoflurane

Sildenafil

Simeprevir

Siponimod

Sirolimus Protein-Bound

Sodium Phosphate

Sodium Phosphate, Dibasic

Sodium Phosphate, Monobasic

Sonidegib

Sotalol

Sparsentan

Sufentanil

Sulpiride

Sultopride

Suvorexant

Tadalafil

Tamsulosin

Tazemetostat

Telaprevir

Telavancin

Tetrabenazine

Tezacaftor

Thiotepa

Tolterodine

Trabectedin

Tramadol

Triclabendazole

Trimipramine

Triptorelin

Upadacitinib

Valbenazine

Vamorolone

Vandetanib

Venlafaxine

Vilazodone

Vinblastine

Vincristine

Vincristine Sulfate Liposome

Vinflunine

Vinorelbine

Vorapaxar

Vorinostat

Warfarin

Zanubrutinib

Zolpidem

Zotepine

Zuclopenthixol

Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Amlodipine

Aripiprazole Lauroxil

Lorazepam

Topiramate

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Relate drugs

How to use Posaconazole (Intravenous)

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins. The medicine must be injected slowly, so your IV tube will need to stay in place for 30 to 90 minutes.

This medicine should come with a patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Warnings

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood tests will be needed to check for unwanted effects.

You should not use atorvastatin (Lipitor®), lovastatin (Mevacor®), pimozide (Orap®), quinidine (Quinaglute®), simvastatin (Zocor®), sirolimus (Rapamune®), venetoclax (Venclexta®), or ergotamine medicines (eg, bromocriptine, dihydroergotamine, ergonovine, ergotamine, methylergonovine, methysergide, Cafergot®, Ergomar®, Wigraine®). Using any of them together with this medicine may increase the chance of unwanted effects.

This medicine can cause changes in heart rhythms, including QT prolongation and torsades de pointes. Check with your doctor right away if you have chest pain or discomfort, fainting, irregular or slow heart rate, or trouble breathing.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow skin or eyes. These could be symptoms of a serious liver problem.

Check with your doctor right away if you have severe diarrhea or vomiting while using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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