Posluma

Generic name: Flotufolastat F 18
Dosage form: intravenous injection
Drug class: Diagnostic radiopharmaceuticals

Usage of Posluma

Posluma (flotufolastat F 18) is an imaging agent used to detect and locate prostate cancer during PET (positron emission tomography) scans. Posluma contains an imaging agent (18F radioscope) which is designed to specifically bind to Prostate-Specific Membrane Antigen (PSMA) on prostate cancer cells which means physicians can accurately identify and locate the prostate cancer cells within the body. Posluma is a Radiohybrid PSMA-targeted PET Imaging Agent.

Posluma received FDA approval based on the results of two phase 3 trials, LIGHTHOUSE (NCT04186819) and SPOTLIGHT (NCT04186845), it was originally called 18F-rhPSMA-7.3 during clinical trials and development.

Posluma side effects

Posulma side effects include:

diarrhea

blood pressure increase

injection site pain.

Before taking Posluma

Posluma is not indicated for use in females.

Radioactive drugs have the potential to cause fetal harm depending on the fetal stage of development and the size of the radiation dose.

There is no data on the presence of this medicine in human milk, the effect on the breastfed infant, or the effect on milk production.

Relate drugs

How to use Posluma

The recommended Poslum adult dose is 296 MBq (8 mCi) as an intravenous bolus injection.

The necessary volume to administer should be calculated based on calibration time and required dose.

The recommended maximum volume of undiluted Posluma is 5 mL.

Posluma may be diluted with 0.9% Sodium Chloride Injection, USP.

Assay the dose in a dose calibrator before administration.

Post Administration Instructions

After the injection, administer an intravenous flush of sterile 0.9% Sodium Chloride Injection to ensure full dose delivery.

Warnings

Radiation Risks. This medicine contributes to a patient’s long-term cumulative radiation exposure.

Risk of Image Misinterpretation. The interpretation of Posluma PET may differ depending on imaging readers, particularly in the prostate/prostate bed region. Because of the associated risk of false positive interpretation, consider multidisciplinary consultation and histopathological confirmation when clinical decision-making hinges on uptake only in the prostate/prostate bed region or only on uptake interpreted as borderline.

What other drugs will affect Posluma

Androgen deprivation therapy (ADT) and other therapies targeting the androgen pathway, such as androgen receptor antagonists, can result in a change in the absorption of this medicine into prostate cancer. It has not been established what the effect of these therapies has on the performance of Posluma PET.

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