Pramipexole

Generic name: Pramipexole
Drug class: Dopaminergic antiparkinsonism agents

Usage of Pramipexole

Pramipexole has some of the same effects as a chemical called dopamine, which occurs naturally in your body. Low levels of dopamine in the brain are associated with Parkinson's disease.

Pramipexole is used to treat symptoms of Parkinson's disease (stiffness, tremors, muscle spasms, and poor muscle control). Pramipexole is also used to treat restless legs syndrome (RLS).

Only immediate-release pramipexole (Mirapex) is approved to treat either Parkinson symptoms or RLS. Extended-release pramipexole (Mirapex ER) is approved only to treat Parkinson symptoms.

Parkinson's and RLS are two separate disorders. Having one of these conditions will not cause you to have the other condition.

Pramipexole may also be used for purposes not listed in this medication guide.

Pramipexole side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Some people taking pramipexole have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness.

Pramipexole may cause serious side effects. Call your doctor at once if you have:

a light-headed feeling, like you might pass out;

hallucinations (seeing or hearing things that are not real);

extreme drowsiness, falling asleep suddenly, even after feeling alert;

tremors, twitching or uncontrollable muscle movements;

unexplained muscle pain, tenderness, or weakness;

vision problems; or

posture changes you cannot control, such as involuntary bending forward of your neck, bending forward at the waist, or tilting sideways when you sit, stand, or walk.

Side effects such as confusion or hallucinations may be more likely in older adults.

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking pramipexole. Talk with your doctor if this occurs.

Common side effects of pramipexole may include:

muscle spasm or muscle weakness;

drowsiness, dizziness, weakness;

confusion, memory problems;

dry mouth;

nausea, constipation;

increased urination; or

sleep problems (insomnia), unusual dreams.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Pramipexole

You should not use pramipexole if you are allergic to it.

Tell your doctor if you have ever had:

low blood pressure;

dizziness after getting up too fast;

daytime drowsiness;

kidney disease; or

problems controlling your muscle movements.

People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for.

It is not known whether pramipexole will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using pramipexole.

It is not known whether pramipexole passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

Relate drugs

How to use Pramipexole

Usual Adult Dose for Parkinson's Disease:

Immediate-release:Initial dose: 0.125 mg orally three times a day Titration: Increase gradually in small dose increments no more frequently than ever 5 to 7 daysMaintenance dose: 1.5 to 4.5 mg per day based on efficacy and tolerabilityMaximum dose: 4.5 mg per dayComment: The following dose titration was used in clinical trials: Week 2, 0.25 mg 3 times a dayWeek 3, 0.5 mg 3 times a dayWeek 4, 0.75 mg 3 times a dayWeek 5, 1 mg 3 times a dayWeek 6, 1.25 mg 3 times a dayWeek 7, 1.5 mg 3 times a day. -When used in combination with levodopa, the levodopa dose was reduced by an average of 27% from baseline providing a concomitant dose of approximately 800 mg per day. Extended-release:Initial dose: 0.375 mg orally once a day Titration: Increase gradually no more frequently than every 5 to 7 days, first dose increase should be to 0.75 mg once a day followed by incremental increases of 0.75 mg; assess therapeutic response and tolerability at a minimum of 5 days after each dose increase.Maximum dose: 4.5 mg per day SWITCHING FROM IMMEDIATE-RELEASE TO EXTENDED-RELEASE:-Patients may be switched overnight from immediate-release tablets to extended-release tablets at the same daily dose; monitor closely to determine if dose adjustments may be necessary.Comments:-If a significant interruption in therapy occurs, re-titration may be necessary; upon discontinuation, doses should be tapered. Use: Treatment of Parkinson's disease

Usual Adult Dose for Restless Legs Syndrome:

Immediate-release:Initial dose: 0.125 mg orally once a day 2 to 3 hours before bedtime Titration: If needed, dose may be titrated upwards by increments of 0.125 mg every 4 to 7 days.Maximum dose: 0.5 mg orally once a day Comments:-Extended-release tablets are not indicated for Restless Legs Syndrome.-Doses of 0.75 mg once a day were used in clinical trials, but were not found to provide additional benefit as compared to the 0.5 mg dose. Use: For the treatment of moderate to severe primary Restless Legs Syndrome.

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What other drugs will affect Pramipexole

Using pramipexole with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

cimetidine;

metoclopramide; or

medicine to treat mental illness, such as chlorpromazine, droperidol, fluphenazine, haloperidol, perphenazine, prochlorperazine, thioridazine, and others.

This list is not complete. Other drugs may affect pramipexole, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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