Pramlintide

Generic name: Pramlintide
Dosage form: subcutaneous solution (1000 mcg/mL)
Drug class: Amylin analogs

Usage of Pramlintide

Pramlintide is a man-made form of a hormone that occurs naturally in the body. Pramlintide lowers blood sugar in three ways. It slows the rate that food moves from your stomach to your intestines, which keeps your blood sugar from rising too fast. Pramlintide also lowers the amount of glucose (sugar) your liver produces. Lastly, pramlintide triggers the feeling of fullness after meals to help control your appetite and decrease how much food you eat.

Pramlintide is used together with insulin to treat type 1 or type 2 diabetes. Pramlintide is usually given after other diabetes medicines have been tried without success.

Pramlintide may also be used for purposes not listed in this medication guide.

Pramlintide side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Pramlintide may cause serious side effects. Call your doctor at once if you have:

severe ongoing nausea; or

severe hypoglycemia--headache, dizziness, drowsiness, vision problems, hunger, weakness, sweating, confusion, irritability, fast heart rate, feeling jittery.

Common side effects of pramlintide may include:

nausea, vomiting, loss of appetite; or

headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Pramlintide

You should not use this medicine if you are allergic to pramlintide or metacresol, or:

if you have a digestive condition called "delayed gastric emptying"; or

if you cannot recognize symptoms of low blood sugar.

To make sure pramlintide is safe for you, tell your doctor if you have:

a history of delayed gastric emptying;

problems with vision (blindness, trouble reading);

if you are unable to check your blood sugars regularly; or

if you have had severe hypoglycemia more than once in the past 6 months.

It is not known whether pramlintide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine.

It is not known whether pramlintide passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Pramlintide should not be used in children.

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How to use Pramlintide

Usual Adult Dose for Diabetes Type 1:

15 mcg suBCutaneously, injecting immediately prior to each major mealComments:-Mealtime insulin doses (including premixed insulins) should be reduced by 50%.-Dose should be increased to next increment (30, 45, or 60 mcg) when no clinically significant nausea has occurred for at least 3 days.-If significant nausea persists at the 45 or 60 mcg dose level, dose should be decreased to 30 mcg.-If the 30 mcg dose is not tolerated, discontinuation should be considered.Use: Adjunctive treatment in patients with type 1 diabetes who use mealtime insulin therapy and who have failed to achieve desired glucose control despite optimal insulin therapy.

Usual Adult Dose for Diabetes Type 2:

60 mcg subcutaneously, injecting immediately prior to each major mealComments:-Mealtime insulin doses (including premixed insulins) should be reduced by 50%.-Dose should be increased from 60 to 120 mcg prior to each major meal when no clinically significant nausea has occurred for at least 3 days.-If significant nausea persists at the 120 mcg dose, dose should be decreased to 60 mcg.Use: Adjunctive treatment in patients with type 2 diabetes who use mealtime insulin therapy and who have failed to achieve desired glucose control despite optimal insulin therapy.

Warnings

You should not use pramlintide if you have a digestive condition called "delayed gastric emptying."

You should not use pramlintide if you cannot recognize symptoms of low blood sugar. Severely low blood sugar (hypoglycemia) may occur within 3 hours after your pramlintide injection. Symptoms may include headache, dizziness, drowsiness, vision problems, hunger, weakness, sweating, confusion, irritability, fast heart rate, or feeling jittery.

What other drugs will affect Pramlintide

Other drugs may interact with pramlintide, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Disclaimer

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