Precatory Bean

Generic name: Abrus Precatorius L.
Brand names: Bead Vine, Black-eyed Susan, Buddhist Rosary Bead, Crab's Eye, Habbat Al-Arus, Jequirity Seed, John Crow Beads, Love Bean, Lucky Bean, Prayer Beads, Precatory Bean, Rosary Pea, Weather Plant

Usage of Precatory Bean

Animal and in vitro data

Limited studies have been conducted in animals. Abrin has been used as a molecular probe to investigate cellular function. It has also been evaluated in the treatment of experimental cancers. Although effective when given intraperitoneally to mice pretreated with L1210 leukemia, no increase in lifespan was noted when the compound was administered IV.(Fodstad 1978) In another study in mice, intraperitoneal abrin over 10 days was effective in reducing solid tumor mass.(Ramnath 2002)

Antidiabetic effects of a methanol leaf extract have been described in rodents,(Umamahesh 2016) whereas a 70% ethanol seed extract demonstrated some mild inhibition of pancreatic lipase.(Elbashir 2018)

Ethanolic extracts of the leaves of Abrus possess d-tubocurarine-like neuromuscular blocking activity.(Wambebe 1984)

Antioxidant activity of the ethanolic extract of A. precatorius is similar to the positive control trolox (water-soluble derivative of vitamin E) in vitro(Elbashir 2018) and has also been observed in drug-induced nephropathy and neuroinflammation murine models.(Falayi 2018, Jeong 2017)

Renal protection from gentamicin was demonstrated by a methanol stem bark extract of A. precatorius in rats. Significant improvements were seen in several renal parameters (ie, serum creatinine, urea) as well as antioxidant enzymes and anti-inflammatory pathway signaling (ie, NF-kappaB).(Falayi 2018)

Inhibition of neuroinflammation has been observed in vitro and in vivo with lonchocarpine isolated from A. precatorius roots via modulation of most inflammatory genes that resulted in suppression of tumor necrosis factor-alpha, inducible nitric oxide synthase, cyclooxygenase-2, interleukin [IL]-1beta, IL-6, and NF-kappaB signaling, plus increased expression of IL-10.(Jeong 2017) Meanwhile, an ethanolic extract of A. precatorius leaves produced significant improvement in asthma-related inflammatory effects (ie, paw edema, histamine-induced bronchoconstriction) in several animal models.(Taur 2017)

Clinical data

Research revels no clinical data as toxicity of the plant has precluded clinical studies. Detoxification of the plant has been studied, potentially facilitating clinical study in the future.(Dhoble 2014)

Precatory Bean side effects

Because of the irritant effects of abrin on the GI mucosa, ingestion of precatory beans causes severe stomach cramping accompanied by nausea, vomiting, severe diarrhea, cold sweat, and fast pulse.Fernando 2001, Joubert 1983 Necklaces made of the pierced seeds have been reported to induce dermatitis.Duke 2003

Before taking Precatory Bean

Avoid use. Information regarding safety and efficacy in pregnancy and lactation is lacking.

How to use Precatory Bean

Clinical studies are lacking for any therapeutic application. Precatory bean is a dangerous poison; one seed if thoroughly chewed has been claimed to be fatal to a child, however the tough, impermeable seed coat reduces its toxic potential.

Warnings

The seeds, roots, and leaves of A. precatorius are all poisonous. The A chain (effectomere) of the constituent abrin is reportedly responsible for the toxic activity. Once inside the cell, the A chain migrates to the 60S unit of the ribosome, acting to inhibit further protein synthesis. Abrin has a strong inhibitory effect on protein synthesis, moderate inhibitory effect on DNA synthesis, and little effect on RNA synthesis.(Wei 1974)

The LD50 of abrin given intraperitoneally to mice is 0.04 mcg;(Wei 1974) 5 mg of the alkaloid abrin is reported to be toxic to humans.(Duke 2003) In goats, ground seeds administered at a dose of 1 and 2 g/kg/day caused death in 2 to 5 days.(Barri 1990) The estimated fatal human dose is 0.1 to 1 mcg/kg, almost half that of ricin.(Alhamdani 2015) In children as little as half of one seed has been fatal.(Chevallier 2001, Fernando 2001)

Coma, circulatory collapse, acute renal failure, and hepatotoxicity have been reported.(Fernando 2001, Joubert 1983) Neurologic symptoms have been reported(Patil 2016) as well as fatalities.(Chevallier 2001, Fernando 2001, Jang 2010, Patil 2016) The toxin is released when the hard outer covering is pierced, thus allowing absorption into the intestinal secretions, by chewing or drilling holes in the seeds for beadwork, ornaments, or jewelry. Intact seeds remain impervious to gastric fluid and pose less of a toxicologic potential.(Sullivan 1981)

The onset of toxicity may be delayed up to 3 days; symptoms may persist for longer than 10 days.(Alhamdani 2015)

Treatment is supportive and symptomatic. Because of the necrotizing action of abrin, gastric lavage or induced emesis should be used cautiously.(Fernando 2001, Patil 2016) Measures to maintain circulation include the correction of hypovolemia and electrolyte disturbances. Alkalinization of the urine to control uremia and enhance toxin excretion has been recommended.(Alhamdani 2015, Fernando 2001, Hardin 1974, Jang 2010)

Recently, studies have demonstrated protection against abrin intoxication with anti-abrin antibodies(Mechaly 2018) and a vaccine-like chimeric protein of abrin A chain combined with an A. precatorius agglutinin.(Tiwari 2017) The chimera vaccine as well as serum containing the antibodies led to 100% survival of all mice immunized against lethal doses of abrin.(Tiwari 2017) Similarly, anti-abrin antibody treatment administered 6 hours after lethal abrin exposure in mice led to a 95% survival rate.(Mechaly 2018)

A radioimmunoassay has been developed for abrin.(Godal 1981)

What other drugs will affect Precatory Bean

None well documented.

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