Premphase
Generic name: Conjugated Estrogens And Medroxyprogesterone
Drug class:
Sex hormone combinations
Usage of Premphase
Estrogen is a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body. Conjugated estrogens are a mixture of estrogen hormones.
Medroxyprogesterone is a form of progesterone, a female hormone important for regulating ovulation and menstruation.
Premphase is a combination medicine used to treat menopause symptoms such as hot flashes and vaginal changes, and to prevent osteoporosis (bone loss) in menopausal women.
Premphase may also be used for purposes not listed in this medication guide.
Premphase side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Premphase may cause serious side effects. Call your doctor at once if you have:
Common side effects of Premphase may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Premphase
You should not use this medicine if you have:
Do not use Premphase if you are pregnant. Tell your doctor right away if you become pregnant during treatment.
Using this medicine can increase your risk of blood clots, stroke, or heart attack. You are even more at risk if you have high blood pressure, diabetes, high cholesterol, if you are overweight, or if you smoke.
Premphase should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions.
Tell your doctor if you have ever had:
Using this medicine may increase your risk of cancer of the breast, uterus, or ovaries. Talk with your doctor about this risk.
Estrogen lowers the hormone needed to produce breast milk and can slow breast milk production. Tell your doctor if you are breast-feeding.
Relate drugs
- Activella
- Angeliq
- Climara Pro
- Combipatch
- Conjugated estrogens and bazedoxifene
- Conjugated estrogens and medroxyprogesterone
- Covaryx
- Covaryx HS
- Myfembree
- Bazedoxifene and conjugated estrogens
- Bijuva
- Drospirenone and estradiol
- Duavee
- EEMT
- EEMT HS
- Elagolix, estradiol, and norethindrone
- Essian
- Esterified estrogens and methyltestosterone
- Estradiol and levonorgestrel
- Estradiol and levonorgestrel transdermal
- Estradiol and norethindrone
- Estradiol and norethindrone (Oral)
- Estradiol and norethindrone transdermal
- Estradiol and norgestimate
- Estradiol and progesterone
- Estradiol, norethindrone, and relugolix
- Estratest
- Leuprolide and norethindrone
- Lopreeza
- Lupaneta Pack
- Menogen
- Mimvey
- Oriahnn
- Prefest
- Premphase
- Prempro
- Prempro Low Dose
- Relugolix, estradiol, and norethindrone
- Syntest D.S.
- Syntest H.S.
How to use Premphase
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
Take the medicine at the same time each day.
Premphase may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to take while you are using Premphase, to help lower this risk. Report any unusual vaginal bleeding right away.
The 28-day Premphase treatment consists of two differently colored pills, 14 of each color. Carefully follow the patient instructions about which pills to take on days 1 through 14 and which pills to take on days 15 through 28.
Your doctor should check your progress on a regular basis to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms.
If you need major surgery or will be on long-term bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using Premphase.
Store at room temperature away from moisture, heat, and light.
Warnings
You should not use Premphase if you have: undiagnosed vaginal bleeding, liver disease, a bleeding disorder, if you will have major surgery, or if you have ever had a heart attack, a stroke, a blood clot, or cancer of the breast, uterus/cervix, or vagina.
Do not use if you are pregnant.
Premphase may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.
Using this medicine can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Estrogens should not be used to prevent heart disease, stroke, or dementia.
What other drugs will affect Premphase
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Many drugs can affect Premphase. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
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The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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