Prevymis

Generic name: Letermovir (oral/injection)
Drug class: Miscellaneous antivirals

Usage of Prevymis

Prevymis is a prescription antiviral medicine used to help prevent cytomegalovirus (CMV) infection and disease in people who have received a stem cell transplant or a kidney transplant and who have a high risk for getting CMV disease.

CMV is a common virus that rarely causes problems in healthy people, but can cause serious illness or even death in people with weakened immune systems, and especially those who have received an organ transplant or a stem cell transplant.

Prevymis is an antiviral medicine that works to prevent CMV infection and disease by inhibiting viral replication.

Prevymis is taken as an oral tablet once a day, or is given by your doctor as an injection through an IV line (intravenously) once a day if you are unable to take the tablets.

Prevymis side effects

Get emergency medical help if you have signs of an allergic reaction to Prevymis: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

fast or irregular heartbeats.

Serious side effects may occur if you also use certain other medications.

Common Prevymis side effects may include:

nausea, diarrhea, vomiting, stomach pain;

swelling in your arms or legs;

cough;

headache; or

feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Prevymis

Some medicines can cause unwanted or dangerous effects when used with Prevymis. Your doctor may need to change your treatment plan if you use any of the following drugs:

pimozide;

cholesterol medication - pitavastatin, simvastatin; or

ergot medicine - dihydroergotamine, ergotamine, ergonovine, methylergonovine.

To make sure Prevymis is safe for you, tell your doctor if you have ever had:

kidney disease;

liver disease;

diabetes; or

high cholesterol or triglycerides (a type of fat in the blood).

It is not known whether Prevymis will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether letermovir passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breastfeeding.

Relate drugs

How to use Prevymis

Usual Adult Dose for CMV Prophylaxis:

480 mg orally or by IV infusion once a day Co-administration with Cyclosporine: 240 mg orally or IV infusion once a day Duration of therapy: Allogeneic Hematopoietic Stem Cell Transplant (HSCT): through Day 100 post-transplantation Kidney Transplant: through Day 200 post-transplantation Comments: -Oral and IV doses may be used interchangeably; patients should be switched to oral therapy as soon as possible due to the presence of hydroxypropyl betadex in the IV formulation. IV infusions are administered over 1 hour. -During clinical trials, the median time to engraftment (defined as absolute neutrophil count of 500/mm3 or greater on 3 consecutive days after transplantation) was 19 days in letermovir-treated patients. -Potentially significant drug interactions resulting in adverse reactions or reduced therapeutic effect of this drug or the concomitant drug are possible, therefore, consider drug interactions when initiating or completing therapy. Uses: - Prophylaxis of cytomegalovirus (CMV) infection and disease in adult CMV-seropositive recipients [R+] of an allogeneic hematopoietic stem cell transplant (HSCT). - Prophylaxis of CMV disease in adult kidney transplant recipients at high risk (Donor CMV seropositive/Recipient CMV seronegative [D+/R-]).

Warnings

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact with letermovir, and some drugs should not be used together.

What other drugs will affect Prevymis

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines and any you start or stop using. If you also use cyclosporine, your Prevymis dose will need to be adjusted.

Other drugs may interact with letermovir, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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