Prialt
Generic name: Ziconotide
Dosage form: intrathecal solution
Drug class:
Miscellaneous analgesics
Usage of Prialt
Prialt is a non-narcotic pain reliever that works by blocking pain signals from the nerves to the brain.
Prialt injection is given by intrathecal administration for around-the-clock treatment of severe chronic pain that cannot be treated with other pain medications.
Prialt is not intended for IV (intravenous) use.
Prialt side effects
Get emergency medical help if you have signs of an allergic reaction to Prialt: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Ziconotide can affect your central nervous system and you may feel less alert. A person caring for you should seek emergency medical attention if you are hard to wake up.
Call your doctor at once if you have:
Common Prialt side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Prialt
You should not be treated with Prialt if you are allergic to ziconotide, or if you have:
Some people using ziconotide have had new or worsening mental problems. You should not be treated with Prialt if you have a history of psychosis (delusions or loss of contact with reality).
Tell your doctor if you have recently used opioid medicine.
Tell your doctor if you are pregnant or plan to become pregnant.
You should not breastfeed while using Prialt.
Relate drugs
- Acephen
- Acephen rectal
- Acetaminophen
- Acetaminophen (Intravenous)
- Acetaminophen (Oral, Rectal)
- Acetaminophen injection
- Acetaminophen rectal
- Actamin
- Actamin Maximum Strength
- Altenol
- Aminofen
- Anacin AF
- Anacin Aspirin Free
- Apra
- Comtrex Sore Throat Relief
- Cetafen
- Children's Mapap
- Children's Nortemp
- Children's Tylenol
- Dolono
- Febrol
- Feverall
- Feverall rectal
- Genapap
- Genebs
- Infantaire
- Mapap
- Mapap Arthritis Pain
- Ofirmev
- Pain-Eze +/Rheu-Thritis
- Paracetamol
- Pharbetol
- Prialt
- Pyrecot
- Pyregesic
- Q-Pap
- Redutemp
- Silapap
- Silapap Childrens
- Tactinal
- Tempra Quicklets
- T-Painol
- Tycolene
- Tylenol
- Vitapap
- Ziconotide
How to use Prialt
Usual Adult Dose for Chronic Pain:
Initial dose: 0.1 mcg/hr (2.4 mcg/day) via intrathecal device -Titrate dose in increments of up to 2.4 mcg/day at intervals of no more than 2 to 3 times per week based on analgesic response and adverse events; adjust pump infusion flow rate as required to achieve new dosing Maximum dose: 19.2 mcg/day (0.8 mcg/hr) Comments: -Administration should be under the direction of a physician experienced in the technique of intrathecal administration and who is familiar with the drug and device labeling. -This drug is intended for intrathecal delivery using the Medtronic SynchroMed(R) II Infusion System and CADD-Micro Ambulatory Infusion Pump; refer to manufacturer's manual for specific instructions and precautions for programming the microinfusion device and/or refilling the reservoir. Use: For the management of severe chronic pain in adult patients for whom intrathecal therapy is warranted, and who are intolerant of, or refractory to other treatment, such as systemic analgesics, adjunctive therapies, or intrathecal morphine.
Warnings
Severe psychiatric symptoms and neurological impairment may occur during treatment with Prialt. You should not receive this medicine if you have a history of psychiatric illness or psychotic event.
You should not use Prialt if you are allergic to ziconotide, or if you have an uncontrolled bleeding or blood clotting disorder.
Prialt must be given only as an intrathecal injection through an infusion pump and should not be injected directly into a vein or other part of the body. Your doctor, nurse, or other healthcare provider will give you this injection.Your doctor may occasionally change your dose or infusion pump flow rate to make sure you get the best results from this medicine.
Tell your doctor if the medicine seems to stop working as well in relieving your pain. Tell your doctor if you regularly use other medicines that make you sleepy. Prialt can add to sleepiness caused by these other medications.
Call your doctor at once if you have a serious side effect, especially fever, neck stiffness, seizure (convulsions), extreme drowsiness or tired feeling, confusion, disorientation, hallucinations, thoughts of hurting yourself, or decreased consciousness.
What other drugs will affect Prialt
Using Prialt with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
Tell your doctor about all your other medicines, especially:
This list is not complete. Other drugs may interact with ziconotide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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