Probenecid

Generic name: Probenecid
Brand names: Benemid
Dosage form: oral tablet (500 mg)
Drug class: Antigout agents

Usage of Probenecid

Probenecid is used to treat gout and gouty arthritis. probenecid reduces the amount of uric acid in your body by causing it to be passed in your urine.

Probenecid is also sometimes given together with penicillin antibiotics (including ampicillin, methicillin, oxacillin, cloxacillin, or nafcillin) to make them more effective.

Probenecid may also be used for purposes not listed in this medication guide.

Probenecid side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Probenecid may cause serious side effects. Call your doctor at once if you have:

worsening gout symptoms;

nausea, vomiting, stomach pain or swelling;

painful or difficult urination;

severe pain in your side or lower back;

blood in your urine;

urine that looks cloudy or foamy;

puffy eyes, swelling in your ankles or feet, weight gain; or

pale or yellowed skin.

Common side effects of probenecid may include:

headache, dizziness;

nausea, vomiting, loss of appetite;

flushing (sudden warmth, redness, or tingly feeling);

sore gums;

urinating more than usual;

itching, rash; or

hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Probenecid

You should not use probenecid if you are allergic to it, or if you have:

uric acid kidney stones;

a gout attack that has already started; or

a blood cell disorder, such as anemia or low white blood cells.

Probenecid should not be given to a child younger than 2 years old.

Tell your doctor if you have ever had:

kidney disease;

a stomach ulcer; or

kidney stones.

Tell your doctor if you are pregnant or breast-feeding.

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How to use Probenecid

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Drink plenty of water to prevent kidney stones while you are taking probenecid.

You may be given other medications to also help prevent kidney stones. Keep using these medicines for as long as your doctor has prescribed.

If you need surgery, tell your surgeon you currently take probenecid. probenecid may affect your body's response to anesthesia.

Call your doctor if your gout symptoms do not improve, or if they get worse. Your doctor may prescribe an additional medicine called colchicine.

Store at room temperature away from moisture, heat, and light.

Warnings

You should not use probenecid if you have uric acid kidney stones, a gout attack that has already started, or a blood cell disorder.

Call your doctor if you have worsening gout symptoms.

What other drugs will affect Probenecid

Tell your doctor about all your other medicines, especially:

acetaminophen (Tylenol);

lorazepam;

methotrexate;

rifampin;

diabetes medicine you take by mouth;

a sulfa drug; or

an NSAID (nonsteroidal anti-inflammatory drug) such as indomethacin, ketoprofen, meclofenamate, or naproxen (Aleve).

This list is not complete. Other drugs may affect probenecid, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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