Procarbazine

Generic name: Procarbazine
Brand names: Matulane
Dosage form: oral capsule (50 mg)
Drug class: Miscellaneous antineoplastics

Usage of Procarbazine

Procarbazine is given with other cancer medicines to treat Hodgkin's Disease (a type of blood cancer).

Procarbazine may also be used for purposes not listed in this medication guide.

Procarbazine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Procarbazine may cause serious side effects. Call your doctor at once if you have:

diarrhea that is watery;

numbness, burning pain, or tingly feeling;

confusion, hallucinations, problems with vision or speech, trouble with walking or daily activities;

feeling unsteady, loss of balance or coordination;

tremors, seizure;

cough, chest pain, trouble breathing;

blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;

bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

low blood cell counts--fever, chills, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath.

Common side effects of procarbazine may include:

low blood cell counts; or

nausea, vomiting.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Procarbazine

You should not take procarbazine if you are allergic to it, or if you have bone marrow suppression.

Tell your doctor if you have ever had:

kidney disease;

liver disease;

anemia (low red blood cells);

low levels of platelets in the blood;

low white blood cell counts;

fluid retention; or

if you have received other cancer medications or radiation within the past 30 days.

Procarbazine may harm an unborn baby. Use effective birth control to prevent pregnancy, and tell your doctor if you become pregnant.

procarbazine may affect fertility (ability to have children) in men.

You should not breastfeed while you are taking procarbazine.

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How to use Procarbazine

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Procarbazine can increase your risk of bleeding or infection. You will need frequent medical tests. Your cancer treatments may be delayed based on the results of these tests.

Store at room temperature away from moisture, heat, and light.

Warnings

Procarbazine can increase your risk of bleeding or infection. Call your doctor if you have unusual bruising or bleeding, or new signs of infection (fever, chills, mouth sores, pale skin).

What other drugs will affect Procarbazine

Using procarbazine with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your other medicines, especially:

blood pressure medication;

an antidepressant or sedative;

diet pills, stimulants, or ADHD medication such as Adderall or Ritalin; or

medicine to treat mental illness or psychosis.

This list is not complete. Other drugs may affect procarbazine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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