Progestins
Drug class: Antineoplastic Agents
Usage of Progestins
Contraception
Prevention of conception in women.
Predominantly used by women who are breastfeeding and in those who do not tolerate estrogens or in whom estrogens are contraindicated.
Levonorgestrel-releasing intrauterine system (Mirena): Intended for women who have had ≥1 child; are in a stable, mutually monogamous relationship; have no history of pelvic inflammatory disease (PID); and have no history of ectopic pregnancy or any condition that would predispose to ectopic pregnancy.
Postcoital (Emergency) Contraception
Prevention of conception after unprotected intercourse (including known or suspected contraceptive failure) as an emergency contraceptive (“morning-after” pills). Postcoital (emergency) contraceptive regimens are not as effective as most other forms of long-term contraception; do not use as routine forms of contraception.
An emergency contraceptive regimen employing a progestin alone (levonorgestrel) appears to be more effective and better tolerated than a common estrogen-progestin emergency contraceptive (“Yuzpe”) regimen when the regimens are initiated within 72 hours of unprotected intercourse; levonorgestrel generally preferred when readily available.
Relate drugs
- Abemaciclib (Systemic)
- Acyclovir (Systemic)
- Adenovirus Vaccine
- Aldomet
- Aluminum Acetate
- Aluminum Chloride (Topical)
- Ambien
- Ambien CR
- Aminosalicylic Acid
- Anacaulase
- Anacaulase
- Anifrolumab (Systemic)
- Antacids
- Anthrax Immune Globulin IV (Human)
- Antihemophilic Factor (Recombinant), Fc fusion protein (Systemic)
- Antihemophilic Factor (recombinant), Fc-VWF-XTEN Fusion Protein
- Antihemophilic Factor (recombinant), PEGylated
- Antithrombin alfa
- Antithrombin alfa
- Antithrombin III
- Antithrombin III
- Antithymocyte Globulin (Equine)
- Antivenin (Latrodectus mactans) (Equine)
- Apremilast (Systemic)
- Aprepitant/Fosaprepitant
- Articaine
- Asenapine
- Atracurium
- Atropine (EENT)
- Avacincaptad Pegol (EENT)
- Avacincaptad Pegol (EENT)
- Axicabtagene (Systemic)
- Clidinium
- Clindamycin (Systemic)
- Clonidine
- Clonidine (Epidural)
- Clonidine (Oral)
- Clonidine injection
- Clonidine transdermal
- Co-trimoxazole
- COVID-19 Vaccine (Janssen) (Systemic)
- COVID-19 Vaccine (Moderna)
- COVID-19 Vaccine (Pfizer-BioNTech)
- Crizanlizumab-tmca (Systemic)
- Cromolyn (EENT)
- Cromolyn (Systemic, Oral Inhalation)
- Crotalidae Polyvalent Immune Fab
- CycloSPORINE (EENT)
- CycloSPORINE (EENT)
- CycloSPORINE (Systemic)
- Cysteamine Bitartrate
- Cysteamine Hydrochloride
- Cysteamine Hydrochloride
- Cytomegalovirus Immune Globulin IV
- A1-Proteinase Inhibitor
- A1-Proteinase Inhibitor
- Bacitracin (EENT)
- Baloxavir
- Baloxavir
- Bazedoxifene
- Beclomethasone (EENT)
- Beclomethasone (Systemic, Oral Inhalation)
- Belladonna
- Belsomra
- Benralizumab (Systemic)
- Benzocaine (EENT)
- Bepotastine
- Betamethasone (Systemic)
- Betaxolol (EENT)
- Betaxolol (Systemic)
- Bexarotene (Systemic)
- Bismuth Salts
- Botulism Antitoxin (Equine)
- Brimonidine (EENT)
- Brivaracetam
- Brivaracetam
- Brolucizumab
- Brompheniramine
- Budesonide (EENT)
- Budesonide (Systemic, Oral Inhalation)
- Bulk-Forming Laxatives
- Bupivacaine (Local)
- BuPROPion (Systemic)
- Buspar
- Buspar Dividose
- Buspirone
- Butoconazole
- Cabotegravir (Systemic)
- Caffeine/Caffeine and Sodium Benzoate
- Calcitonin
- Calcium oxybate, magnesium oxybate, potassium oxybate, and sodium oxybate
- Calcium Salts
- Calcium, magnesium, potassium, and sodium oxybates
- Candida Albicans Skin Test Antigen
- Cantharidin (Topical)
- Capmatinib (Systemic)
- Carbachol
- Carbamide Peroxide
- Carbamide Peroxide
- Carmustine
- Castor Oil
- Catapres
- Catapres-TTS
- Catapres-TTS-1
- Catapres-TTS-2
- Catapres-TTS-3
- Ceftolozane/Tazobactam (Systemic)
- Cefuroxime
- Centruroides Immune F(ab′)2
- Cetirizine (EENT)
- Charcoal, Activated
- Chloramphenicol
- Chlorhexidine (EENT)
- Chlorhexidine (EENT)
- Cholera Vaccine Live Oral
- Choriogonadotropin Alfa
- Ciclesonide (EENT)
- Ciclesonide (Systemic, Oral Inhalation)
- Ciprofloxacin (EENT)
- Citrates
- Dacomitinib (Systemic)
- Dapsone (Systemic)
- Dapsone (Systemic)
- Daridorexant
- Darolutamide (Systemic)
- Dasatinib (Systemic)
- DAUNOrubicin and Cytarabine
- Dayvigo
- Dehydrated Alcohol
- Delafloxacin
- Delandistrogene Moxeparvovec (Systemic)
- Dengue Vaccine Live
- Dexamethasone (EENT)
- Dexamethasone (Systemic)
- Dexmedetomidine
- Dexmedetomidine
- Dexmedetomidine
- Dexmedetomidine (Intravenous)
- Dexmedetomidine (Oromucosal)
- Dexmedetomidine buccal/sublingual
- Dexmedetomidine injection
- Dextran 40
- Diclofenac (Systemic)
- Dihydroergotamine
- Dimethyl Fumarate (Systemic)
- Diphenoxylate
- Diphtheria and Tetanus Toxoids
- Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed
- Diroximel Fumarate (Systemic)
- Docusate Salts
- Donislecel-jujn (Systemic)
- Doravirine, Lamivudine, and Tenofovir Disoproxil
- Doxepin (Systemic)
- Doxercalciferol
- Doxycycline (EENT)
- Doxycycline (Systemic)
- Doxycycline (Systemic)
- Doxylamine
- Duraclon
- Duraclon injection
- Dyclonine
- Edaravone
- Edluar
- Efgartigimod Alfa (Systemic)
- Eflornithine
- Eflornithine
- Elexacaftor, Tezacaftor, And Ivacaftor
- Elranatamab (Systemic)
- Elvitegravir, Cobicistat, Emtricitabine, and tenofovir Disoproxil Fumarate
- Emicizumab-kxwh (Systemic)
- Emtricitabine and Tenofovir Disoproxil Fumarate
- Entrectinib (Systemic)
- EPINEPHrine (EENT)
- EPINEPHrine (Systemic)
- Erythromycin (EENT)
- Erythromycin (Systemic)
- Estrogen-Progestin Combinations
- Estrogen-Progestin Combinations
- Estrogens, Conjugated
- Estropipate; Estrogens, Esterified
- Eszopiclone
- Ethchlorvynol
- Etranacogene Dezaparvovec
- Evinacumab (Systemic)
- Evinacumab (Systemic)
- Factor IX (Human), Factor IX Complex (Human)
- Factor IX (Recombinant)
- Factor IX (Recombinant), albumin fusion protein
- Factor IX (Recombinant), Fc fusion protein
- Factor VIIa (Recombinant)
- Factor Xa (recombinant), Inactivated-zhzo
- Factor Xa (recombinant), Inactivated-zhzo
- Factor XIII A-Subunit (Recombinant)
- Faricimab
- Fecal microbiota, live
- Fedratinib (Systemic)
- Fenofibric Acid/Fenofibrate
- Fibrinogen (Human)
- Flunisolide (EENT)
- Fluocinolone (EENT)
- Fluorides
- Fluorouracil (Systemic)
- Flurbiprofen (EENT)
- Flurbiprofen (EENT)
- Flurbiprofen (EENT)
- Flurbiprofen (EENT)
- Fluticasone (EENT)
- Fluticasone (Systemic, Oral Inhalation)
- Fluticasone and Vilanterol (Oral Inhalation)
- Ganciclovir Sodium
- Gatifloxacin (EENT)
- Gentamicin (EENT)
- Gentamicin (Systemic)
- Gilteritinib (Systemic)
- Glofitamab
- Glycopyrronium
- Glycopyrronium
- Gonadotropin, Chorionic
- Goserelin
- Guanabenz
- Guanadrel
- Guanethidine
- Guanfacine
- Haemophilus b Vaccine
- Hepatitis A Virus Vaccine Inactivated
- Hepatitis B Vaccine Recombinant
- Hetlioz
- Hetlioz LQ
- Homatropine
- Hydrocortisone (EENT)
- Hydrocortisone (Systemic)
- Hydroquinone
- Hylorel
- Hyperosmotic Laxatives
- Ibandronate
- Igalmi buccal/sublingual
- Imipenem, Cilastatin Sodium, and Relebactam
- Inclisiran (Systemic)
- Infliximab, Infliximab-dyyb
- Influenza Vaccine Live Intranasal
- Influenza Vaccine Recombinant
- Influenza Virus Vaccine Inactivated
- Inotuzumab
- Insulin Human
- Interferon Alfa
- Interferon Beta
- Interferon Gamma
- Intermezzo
- Intuniv
- Iodoquinol (Topical)
- Iodoquinol (Topical)
- Ipratropium (EENT)
- Ipratropium (EENT)
- Ipratropium (Systemic, Oral Inhalation)
- Ismelin
- Isoproterenol
- Ivermectin (Systemic)
- Ivermectin (Topical)
- Ixazomib Citrate (Systemic)
- Japanese Encephalitis Vaccine
- Kapvay
- Ketoconazole (Systemic)
- Ketorolac (EENT)
- Ketorolac (EENT)
- Ketorolac (EENT)
- Ketorolac (EENT)
- Ketorolac (Systemic)
- Ketotifen
- Lanthanum
- Lecanemab
- Lefamulin
- Lemborexant
- Lenacapavir (Systemic)
- Leniolisib
- Letermovir
- Letermovir
- Levodopa/Carbidopa
- LevoFLOXacin (EENT)
- LevoFLOXacin (Systemic)
- L-Glutamine
- Lidocaine (Local)
- Lidocaine (Systemic)
- Linezolid
- Lofexidine
- Loncastuximab
- Lotilaner (EENT)
- Lotilaner (EENT)
- Lucemyra
- Lumasiran Sodium
- Lumryz
- Lunesta
- Mannitol
- Mannitol
- Mb-Tab
- Measles, Mumps, and Rubella Vaccine
- Mecamylamine
- Mechlorethamine
- Mechlorethamine
- Melphalan (Systemic)
- Meningococcal Groups A, C, Y, and W-135 Vaccine
- Meprobamate
- Methoxy Polyethylene Glycol-epoetin Beta (Systemic)
- Methyldopa
- Methylergonovine, Ergonovine
- MetroNIDAZOLE (Systemic)
- MetroNIDAZOLE (Systemic)
- Miltown
- Minipress
- Minocycline (EENT)
- Minocycline (Systemic)
- Minoxidil (Systemic)
- Mometasone
- Mometasone (EENT)
- Moxifloxacin (EENT)
- Moxifloxacin (Systemic)
- Nalmefene
- Naloxone (Systemic)
- Natrol Melatonin + 5-HTP
- Nebivolol Hydrochloride
- Neomycin (EENT)
- Neomycin (Systemic)
- Netarsudil Mesylate
- Nexiclon XR
- Nicotine
- Nicotine
- Nicotine
- Nilotinib (Systemic)
- Nirmatrelvir
- Nirmatrelvir
- Nitroglycerin (Systemic)
- Ofloxacin (EENT)
- Ofloxacin (Systemic)
- Oliceridine Fumarate
- Olipudase Alfa-rpcp (Systemic)
- Olopatadine
- Omadacycline (Systemic)
- Osimertinib (Systemic)
- Oxacillin
- Oxymetazoline
- Pacritinib (Systemic)
- Palovarotene (Systemic)
- Paraldehyde
- Peginterferon Alfa
- Peginterferon Beta-1a (Systemic)
- Penicillin G
- Pentobarbital
- Pentosan
- Pilocarpine Hydrochloride
- Pilocarpine, Pilocarpine Hydrochloride, Pilocarpine Nitrate
- Placidyl
- Plasma Protein Fraction
- Plasminogen, Human-tmvh
- Pneumococcal Vaccine
- Polymyxin B (EENT)
- Polymyxin B (Systemic, Topical)
- PONATinib (Systemic)
- Poractant Alfa
- Posaconazole
- Potassium Supplements
- Pozelimab (Systemic)
- Pramoxine
- Prazosin
- Precedex
- Precedex injection
- PrednisoLONE (EENT)
- PrednisoLONE (Systemic)
- Progestins
- Propylhexedrine
- Protamine
- Protein C Concentrate
- Protein C Concentrate
- Prothrombin Complex Concentrate
- Pyrethrins with Piperonyl Butoxide
- Quviviq
- Ramelteon
- Relugolix, Estradiol, and Norethindrone Acetate
- Remdesivir (Systemic)
- Respiratory Syncytial Virus Vaccine, Adjuvanted (Systemic)
- RifAXIMin (Systemic)
- Roflumilast (Systemic)
- Roflumilast (Topical)
- Roflumilast (Topical)
- Rotavirus Vaccine Live Oral
- Rozanolixizumab (Systemic)
- Rozerem
- Ruxolitinib (Systemic)
- Saline Laxatives
- Selenious Acid
- Selexipag
- Selexipag
- Selpercatinib (Systemic)
- Sirolimus (Systemic)
- Sirolimus, albumin-bound
- Smallpox and Mpox Vaccine Live
- Smallpox Vaccine Live
- Sodium Chloride
- Sodium Ferric Gluconate
- Sodium Nitrite
- Sodium oxybate
- Sodium Phenylacetate and Sodium Benzoate
- Sodium Thiosulfate (Antidote) (Systemic)
- Sodium Thiosulfate (Protectant) (Systemic)
- Somatrogon (Systemic)
- Sonata
- Sotorasib (Systemic)
- Suvorexant
- Tacrolimus (Systemic)
- Tafenoquine (Arakoda)
- Tafenoquine (Krintafel)
- Talquetamab (Systemic)
- Tasimelteon
- Tedizolid
- Telotristat
- Tenex
- Terbinafine (Systemic)
- Tetrahydrozoline
- Tezacaftor and Ivacaftor
- Theophyllines
- Thrombin
- Thrombin Alfa (Recombinant) (Topical)
- Timolol (EENT)
- Timolol (Systemic)
- Tixagevimab and Cilgavimab
- Tobramycin (EENT)
- Tobramycin (Systemic)
- TraMADol (Systemic)
- Trametinib Dimethyl Sulfoxide
- Trancot
- Tremelimumab
- Tretinoin (Systemic)
- Triamcinolone (EENT)
- Triamcinolone (Systemic)
- Trimethobenzamide
- Tucatinib (Systemic)
- Unisom
- Vaccinia Immune Globulin IV
- Valoctocogene Roxaparvovec
- Valproate/Divalproex
- Valproate/Divalproex
- Vanspar
- Varenicline (Systemic)
- Varenicline (Systemic)
- Varenicline Tartrate (EENT)
- Vecamyl
- Vitamin B12
- Vonoprazan, Clarithromycin, and Amoxicillin
- Wytensin
- Xyrem
- Xywav
- Zaleplon
- Zirconium Cyclosilicate
- Zolpidem
- Zolpidem (Oral)
- Zolpidem (Oromucosal, Sublingual)
- ZolpiMist
- Zoster Vaccine Recombinant
- 5-hydroxytryptophan, melatonin, and pyridoxine
How to use Progestins
Administration
Administer norethindrone orally.
Administer levonorgestrel orally or as an intrauterine system.
Administer etonogestrel implant by sub-Q insertion.
Oral Administration
ContraceptionTake as near as possible to the same time each day (i.e., at regular 24-hour intervals) and continue daily without interruption to ensure maximum contraceptive efficacy.
If vomiting occurs soon after a dose, use a back-up method of contraception (e.g., condoms, foam, sponges) for 48 hours.
Available in a mnemonic dispensing package designed to aid the user in complying with the prescribed dosing regimen.
Postcoital (Emergency) ContraceptionPlan B One-Step, Next Choice One Dose: Administer as soon as possible but preferably within 72 hours following unprotected sex.
Levonorgestrel 2-dose regimen: Administer the first dose as soon as possible within 72 hours of unprotected sex followed by a second dose 12 hours after the first dose.
Most data support administration of either regimen up to 120 hours† [off-label] after unprotected intercourse if necessary, but efficacy decreases as initiation of contraception becomes more remote from unprotected intercourse.
May be used at any time during the menstrual cycle. Efficacy not established if administered >120 hours after unprotected sex.
Plan B One-Step, Next Choice One Dose : If vomiting occurs within 2 hours after administration, contact clinician to discuss repeating the dose.
Levonorgestrel 2-dose regimen: If vomiting occurs within 2 hours after administration of either the first or second dose, contact clinician to discuss taking another dose.
Food not effective in reducing adverse GI effects (i.e., nausea).
Sub-Q Administration
Insert etonogestrel implant (Implanon) subdermally in the inner aspect of the upper arm about 6–8 cm above the elbow crease. Consult manufacturer’s labeling for proper method of administration and associated precautions.
Intrauterine Administration
Insert levonorgestrel-releasing intrauterine system (Mirena) into the uterine cavity under strict aseptic conditions. (See Intrauterine Device Considerations under Cautions.) Consult manufacturer’s labeling for proper methods of inserting and removing the intrauterine system and for associated precautions.
Dosage
When switching contraceptive methods, initiate new therapy in a manner that ensures continuous contraceptive coverage based on the mechanism of action of both methods.
Adults
Contraception OralNorethindrone: 0.35 mg daily. Take 1 tablet each day and continue daily without interruption. Start on the first day of the menstrual cycle. If the first dose is taken on another day, use back-up method of contraception (e.g., condom, spermicide) for each sexual encounter for the next 48 hours.
Women switching from estrogen-progestin oral contraceptives: Start norethindrone on the day after the last hormonally active tablet.
Women may start using norethindrone tablets on the next day after a miscarriage or an abortion.
Women whose infants are only partially breast-fed may begin norethindrone 3 weeks after delivery. Women who are exclusively breast-feeding their infants may begin 6 weeks after delivery.
When a dose is taken >3 hours late or if one or more consecutive doses are missed, take the missed dose as soon as remembered, then resume regular schedule; use a back-up method of contraception (e.g., condom, spermicide) for 48 hours. If unsure of what drug regimen to take as a result of missed tablets, use a back-up method of contraception for each sexual encounter and take one tablet daily until clinician contacted.
Sub-QEtonogestrel contraceptive implant (Implanon): One 68-mg implant every 3 years.
To initiate therapy in women who did not use hormonal contraception in the preceding month, insert the contraceptive implant on or before day 5 of the cycle; a back-up method of contraception is not needed.
Women switching from estrogen-progestin oral contraceptives, contraceptive transdermal system, or vaginal contraceptive ring: Insert the contraceptive implant within 7 days of the last hormonally active tablet, removal of a transdermal patch, or removal of the vaginal ring; a back-up method of contraception is not needed.
Women switching from progestin-only oral contraceptives: Insert the contraceptive implant on any day of the month (without skipping any day between receiving the last progestin oral contraceptive and the initial administration of the implant); a back-up method of contraception is not needed.
Women switching from a progestin-only contraceptive injection: Insert the contraceptive implant on the same day as the next contraceptive injection would have been due; a back-up method of contraception is not needed.
Women switching from a progestin-containing intrauterine device: Insert the contraceptive implant on the same day as the intrauterine device is removed; a back-up method of contraception is not needed.
The contraceptive implant can be inserted immediately after a first-trimester abortion. If therapy with the contraceptive insert is not initiated within 5 days of a first-trimester abortion, follow the instructions for women who did not use hormonal contraception in the preceding month.
The contraceptive implant can be inserted 21–28 days after a second-trimester abortion.
The contraceptive implant can be inserted 21–28 days postpartum in women who are not exclusively breast-feeding; a back-up method of contraception is not needed. The implant can be inserted after the fourth postpartum week in women who are exclusively breast-feeding their infant. If implant insertion occurs >4 weeks postpartum, use back-up method of contraception for 7 days.
Remove implant 3 years after insertion. At time of implant removal, may insert another implant to continue therapy.
IntrauterineLevonorgestrel-releasing intrauterine contraceptive system (Mirena): One system containing 52 mg every 5 years.
To initiate therapy, insert the intrauterine contraceptive system within 7 days of menses onset.
The intrauterine contraceptive system can be inserted immediately after a first-trimester abortion; delay insertion until involution of the uterus is complete after a second-trimester abortion.
Do not insert the intrauterine contraceptive system until 6 weeks postpartum or after involution of the uterus is complete.
Remove the intrauterine contraceptive system after 5 years of use (contraceptive efficacy >5 years not established). At time of system removal, may insert another intrauterine contraceptive system to continue therapy; removal and replacement with a new system can be done at any time during the menstrual cycle.
For women with regular menstrual cycles who wish to initiate an alternative contraceptive method, remove the intrauterine system during the first 7 days of a menstrual cycle and start new method. For those with irregular cycles or amenorrhea or for those in whom the system is removed after the seventh day of the menstrual cycle, initiate the new contraceptive method at least 7 days before removal of the intrauterine system.
Postcoital (Emergency) Contraception OralLevonorgestrel one-dose regimen (e.g., Plan B One-Step, Next Choice One Dose): Single 1.5-mg dose taken as soon as possible within 72 hours of unprotected intercourse.
Levonorgestrel 2-dose regimen: 0.75-mg dose taken as soon as possible within 72 hours of unprotected intercourse, followed by a second 0.75-mg dose 12 hours after the first dose.
If necessary, the first dose of either the single or 2-dose regimen can be administered up to120 hours† [off-label] after unprotected intercourse, but efficacy decreases the longer initiation of contraception is delayed.
Repeated postcoital (emergency) contraception use indicates need for counseling about other contraceptive options. Safety of recurrent use not established but risk appears low, even within same menstrual cycle. Consider possibility that risk of adverse effects (e.g., menstrual irregularities) may be increased with frequently repeated postcoital contraception.
FDA has approved Plan B One-Step for OTC status for women of childbearing potential regardless of age. Next Choice One Dose is a prescription-only preparation for women <17 years of age and an OTC preparation for women ≥17 years of age.
Warnings
Contraindications
Warnings/Precautions
Warnings
Ectopic PregnancyConsider the possibility of ectopic pregnancy if pregnancy or severe lower abdominal pain occurs in women using progestin contraception, including those using postcoital (emergency) regimens. Follow-up physical or pelvic examination recommended if there are questions about general health or pregnancy status of women after levonorgestrel administration. Current evidence does not support increased risk of ectopic pregnancy after use of levonorgestrel for postcoital (emergency) contraception in the general population; rather, preventing pregnancy overall actually reduces absolute risk. Postcoital contraception with levonorgestrel can be used in women with history of ectopic pregnancy.
Existing PregnancyLevonorgestrel 0.75 or 1.5 mg used for postcoital (emergency) contraception is not effective in terminating an existing pregnancy.
Ovarian FolliclesPossible delayed atresia of ovarian follicles, resulting in follicular enlargement. Follicular enlargement generally is asymptomatic or associated with mild abdominal pain and resolves spontaneously; in rare cases, surgery may be required.
Bleeding IrregularitiesPossible breakthrough bleeding or irregular vaginal bleeding. Perform adequate diagnostic tests in patients with undiagnosed vaginal bleeding. Rule out pregnancy in patients with amenorrhea. If pregnancy occurs, discontinue therapy.
Postcoital (emergency) contraception: Irregular vaginal bleeding also possible with postcoital contraceptive regimens; rule out pregnancy if menses is delayed >7 days after anticipated onset.
Carcinoma of Breast and Reproductive OrgansInsufficient data to determine whether use of progestin-only contraceptives is associated with an increased risk of breast cancer or cervical carcinoma. (See Contraindications under Cautions.)
Hepatic EffectsInsufficient data to determine whether use of progestin-only contraceptives is associated with increased risk of hepatocellular carcinoma. (See Contraindications and also see Hepatic Impairment under Cautions.)
Implant ConsiderationsCarefully follow recommended procedures for insertion and removal of implant to minimize potential for complications.
If infection develops at insertion site, initiate appropriate treatment; if infection persists, remove the implant.
Intrauterine Device ConsiderationsEvaluate women for suitability (i.e., exclude pregnancy; evaluate for genital infections, risk for ectopic pregnancy, and/or PID) prior to insertion of levonorgestrel-releasing intrauterine device. Insert the device under strict aseptic conditions.
Possible complications include intrauterine pregnancy with the device in place; if this occurs, remove device to reduce possibility of complications to the woman (e.g., septicemia, septic shock, death) and fetus (e.g., miscarriage, sepsis, premature labor, premature delivery). Long-term effects unknown if pregnancy is continued with the intrauterine device in place. (See Fetal/Neonatal Morbidity and Mortality under Cautions.)
Sepsis following insertion of the device reported rarely. Increased risk of infective endocarditis in women with valvular or congenital heart disease and in those with surgically constructed systemic-pulmonary shunts; prophylactic anti-infective therapy recommended at time of insertion for women with congenital heart disease.
Other complications include penetration or embedment of the device in the myometrium and perforation of the uterus or cervix.
Fetal/Neonatal Morbidity and MortalityCongenital abnormalities reported infrequently in neonates born to women with a levonorgestrel-releasing intrauterine device in place during the pregnancy.
Thromboembolic DisordersThromboembolic events (i.e., pulmonary embolism, stroke) reported in patients using etonogestrel implant (Implanon).
General Precautions
Physical Examination and Follow-upAnnual medical history and physical examination advised with long-term progestin therapy. Physical examination may be deferred until after initiation of oral contraceptives if requested by the woman and judged appropriate by the clinician. Physical examination not required prior to initiating therapy with oral levonorgestrel for postcoital (emergency) contraception. Perform complete medical examination prior to initiating therapy with etonogestrel implant or levonorgestrel-releasing intrauterine system. Exercise particular care in women with family history of breast cancer or those who have breast nodules.
Metabolic EffectsSlight deterioration in glucose tolerance and increases in plasma insulin reported. Monitor prediabetic and diabetic patients.
Altered lipid metabolism (decreased HDL, HDL2, apolipoprotein A-I and A-II; increased hepatic lipase) noted; no change in total cholesterol, LDL, VLDL, or HDL3 observed. Closely monitor women with hyperlipidemia.
Ocular EffectsObtain ophthalmologist assessment for contact lens wearers who develop visual disturbances or changes in lens tolerance.
DepressionExercise caution in women with a history of depression; discontinue if severe depression recurs during use.
HeadacheDiscontinue contraceptive and evaluate cause if migraine occurs or is exacerbated, or when new headache pattern develops that is recurrent, persistent, or severe.
HIV and STDsDoes not protect against HIV infection or other sexually transmitted diseases (STDs).
Fertility Following UseRapid return of fertility likely following levonorgestrel use for emergency contraception. Continue or initiate routine methods of contraception as soon as possible following levonorgestrel to ensure ongoing pregnancy prevention.
Specific Populations
PregnancyLevonorgestrel-releasing intrauterine contraceptive system (Mirena): Category X.
Rule out pregnancy prior to initiating therapy. Rule out pregnancy in patients with amenorrhea. If pregnancy occurs, discontinue therapy.
Postcoital (emergency) contraception: No need to rule out pregnancy with postcoital contraceptive regimens. Postcoital contraceptive regimens (i.e., levonorgestrel, estrogen-progestins regimens) do not exhibit abortifacient properties and do not interrupt pregnancy once endometrial implantation has occurred. No known harm to pregnant woman, course of pregnancy, or fetus from postcoital contraceptive regimens.
Most studies have revealed no effects on fetal development associated with long-term use of oral progestin contraceptives.
LactationSmall amounts of progestins are distributed into milk. Adverse effects, such as jaundice, reported rarely in infants.
Postcoital (emergency) contraception: Breast-feeding can continue without restriction during postcoital contraceptive regimens.
Pediatric UseSafety and efficacy of progestin contraceptives established in women of reproductive age. Safety and efficacy of long-term progestin contraceptives expected to be identical for postpubertal adolescents <16 years of age and women ≥16 years of age. Safety and efficacy of progestin emergency contraceptives expected to be identical for postpubertal adolescents <17 years of age and women ≥17 years of age. Not indicated before menarche.
Geriatric UseProgestin contraceptives not evaluated in women >65 years of age; not indicated for use in postmenopausal women.
Hepatic ImpairmentSteroid hormones (including oral contraceptives) may be poorly metabolized in patients with hepatic dysfunction; use with caution in those individuals. (See Contraindications under Cautions.)
Postcoital (emergency) contraception: No precautions appear necessary with short-term postcoital contraceptive regimens; benefits outweigh any theoretical or known risk.
Common Adverse Effects
Norethindrone tablets: Bleeding irregularities (e.g., frequent or irregular bleeding), headache, breast tenderness, nausea, dizziness.
Levonorgestrel tablets: Nausea, abdominal pain, fatigue, headache, menstrual changes (e.g., heavier or lighter menstrual bleeding), dizziness, breast tenderness. Postcoital (emergency) contraceptive regimens better tolerated with levonorgestrel than with estrogen-progestins.
Etonogestrel implants: Bleeding irregularities (e.g., frequent, heavy, or prolonged bleeding, spotting).
Levonorgestrel-releasing intrauterine system: Abdominal pain, leukorrhea, headache, vaginitis, back pain, breast pain, acne, depression, hypertension, upper respiratory infection, nausea, nervousness, dysmenorrhea, weight increase, skin disorder, decreased libido, abnormal Pap smear, sinusitis.
What other drugs will affect Progestins
Specific Drugs
Drug
Interaction
Anticonvulsants (Carbamazepine, felbamate, oxcarbazepine, phenytoin, topiramate)
Possible reduced contraceptive efficacy
Antifungal agents, azole
Possible increased plasma concentrations of contraceptive steroids with itraconazole or ketoconazole
Anti-infective agents
Interaction unlikely with most anti-infective agents
Antiretroviral agents
Possible changes in pharmacokinetics of orally administered progestins with some HIV protease inhibitors
Barbiturates
Possible reduced contraceptive efficacy
Bosentan
Possible reduced contraceptive efficacy
Griseofulvin
Possible reduced contraceptive efficacy
Modafinil
Possible reduced contraceptive efficacy
Rifampin
Possible reduced contraceptive efficacy
St. John’s wort (Hypericum perforatum)
Possible reduced contraceptive efficacy
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