Pronestyl

Generic name: Procainamide
Drug class: Group I antiarrhythmics

Usage of Pronestyl

Procainamide injection is used to treat irregular heartbeats and to slow an overactive heart. When the heart has a normal heartbeat (rhythm), it will work more efficiently. Procainamide works by slowing the nerve impulses in the heart and reducing the sensitivity of heart tissues.

This medicine is available only with your doctor's prescription.

The oral dosage forms of this medicine are no longer available in the United States.

Pronestyl side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Less common

Fever and chills

joint pain or swelling

pains with breathing

skin rash or itching

Rare

Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, or warmth at the injection site

Confusion

fever or sore mouth, gums, or throat

hallucinations (seeing, hearing, or feeling things that are not there)

mental depression

unusual bleeding or bruising

unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Decrease in urination

dizziness (severe) or fainting

drowsiness

fast or irregular heartbeat

nausea and vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Diarrhea

hardening or thickening of the skin where the needle is placed

loss of appetite

Less common

Dizziness or lightheadedness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Pronestyl

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of procainamide injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

No information is available on the relationship of age to the effects of procainamide injection in geriatric patients. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving procainamide injection.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Bepridil

Cisapride

Dronedarone

Fingolimod

Grepafloxacin

Levoketoconazole

Levomethadyl

Mesoridazine

Pimozide

Piperaquine

Saquinavir

Sparfloxacin

Terfenadine

Thioridazine

Vernakalant

Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acecainide

Adagrasib

Ajmaline

Alcuronium

Alfuzosin

Amiodarone

Amisulpride

Amitriptyline

Amoxapine

Anagrelide

Apomorphine

Aprindine

Aripiprazole

Aripiprazole Lauroxil

Arsenic Trioxide

Artemether

Asenapine

Astemizole

Atazanavir

Atracurium

Azithromycin

Buprenorphine

Bupropion

Buserelin

Ceritinib

Chloral Hydrate

Chloroquine

Chlorpromazine

Ciprofloxacin

Cisatracurium

Citalopram

Clarithromycin

Clofazimine

Clomipramine

Clozapine

Cobicistat

Crizotinib

Dabrafenib

Darunavir

Dasatinib

Degarelix

Delamanid

Desipramine

Deslorelin

Deutetrabenazine

Dexmedetomidine

Disopyramide

Dofetilide

Dolasetron

Domperidone

Donepezil

Doxacurium

Doxepin

Droperidol

Efavirenz

Eliglustat

Encorafenib

Enflurane

Entrectinib

Erythromycin

Escitalopram

Etrasimod

Fexinidazole

Flecainide

Fluconazole

Fluoxetine

Formoterol

Foscarnet

Fostemsavir

Gallamine

Gatifloxacin

Gemifloxacin

Gepirone

Glasdegib

Gonadorelin

Goserelin

Granisetron

Halofantrine

Haloperidol

Halothane

Hexafluorenium

Histrelin

Hydroquinidine

Hydroxychloroquine

Hydroxyzine

Ibutilide

Iloperidone

Imipramine

Inotuzumab Ozogamicin

Isoflurane

Isradipine

Ivabradine

Ivosidenib

Ketoconazole

Lacosamide

Lapatinib

Lefamulin

Lenvatinib

Leuprolide

Levofloxacin

Lidocaine

Lidoflazine

Lofexidine

Lopinavir

Lorcainide

Lumefantrine

Macimorelin

Mefloquine

Methadone

Metocurine

Metronidazole

Mifepristone

Mirtazapine

Mivacurium

Mobocertinib

Moricizine

Moxifloxacin

Nafarelin

Nalidixic Acid

Nilotinib

Norfloxacin

Nortriptyline

Octreotide

Ofloxacin

Olanzapine

Ondansetron

Osilodrostat

Osimertinib

Oxaliplatin

Ozanimod

Pacritinib

Paliperidone

Pancuronium

Paroxetine

Pasireotide

Pazopanib

Pentamidine

Phenobarbital

Pimavanserin

Pipecuronium

Pirmenol

Pitolisant

Ponesimod

Posaconazole

Prilocaine

Primidone

Probucol

Promethazine

Propafenone

Protriptyline

Quetiapine

Quinidine

Quinine

Quizartinib

Relugolix

Ribociclib

Risperidone

Rocuronium

Selpercatinib

Sertindole

Sertraline

Sevoflurane

Siponimod

Sodium Phosphate

Sodium Phosphate, Dibasic

Sodium Phosphate, Monobasic

Solifenacin

Sorafenib

Sotalol

Spiramycin

Succinylcholine

Sulfamethoxazole

Sulpiride

Sultopride

Sunitinib

Tacrolimus

Telavancin

Telithromycin

Tetrabenazine

Toremifene

Trazodone

Triclabendazole

Trifluoperazine

Trimethoprim

Trimipramine

Triptorelin

Tubocurarine

Vandetanib

Vardenafil

Vecuronium

Vemurafenib

Vilanterol

Vinflunine

Voclosporin

Voriconazole

Zolmitriptan

Zotepine

Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Cimetidine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Relate drugs

How to use Pronestyl

A nurse or other trained health professional will give you this medicine in a hospital. This medicine is given through a needle placed in one of your veins.

Your doctor will only give you a few doses of this medicine until your condition improves, and then you may be switched to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor.

Warnings

It is important that your doctor check your progress carefully while you are receiving this medicine to make sure it is working properly. This will allow necessary changes in the amount of medicine you receive and may also help reduce side effects.

Dizziness or lightheadedness may occur with this medicine, especially in elderly patients and when large doses are used. Patients should use extra care to avoid falling. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert.

Disclaimer

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