Propylhexedrine

Brand names: Benzedrex
Drug class: Antineoplastic Agents

Usage of Propylhexedrine

Nasal Congestion

Self-medication for temporary relief of nasal congestion associated with the common cold, hay fever, or other allergies.

As effective as other topical vasoconstrictors.

Topical nasal decongestants often preferred for short-term treatment; oral agents preferred for prolonged treatment. (See Overuse under Cautions.)

Reduce swelling and facilitate visualization of nasal and pharyngeal membranes prior to surgery or diagnostic procedures.

Open obstructed eustachian ostia in patients with ear inflammation.

Relate drugs

How to use Propylhexedrine

Administration

Intranasal Administration

Administer topically to the nasal mucosa as an inhalation.

Avoid contamination of the inhaler tip; inhaler is for single-patient use only.

Warm drug container in the hands prior to use to increase drug volatility.

Inhale vapor through each nostril while head is erect; blow nose thoroughly after 3–5 minutes.

Supervise use by children 6–12 years of age.

Dosage

The Benzedrex propylhexedrine inhaler delivers 0.4–0.5 mg of the drug in each 800 mL of air.

Pediatric Patients

Nasal Congestion Intranasal

Children ≥6 years of age: 2 inhalations (0.4–0.5 mg) in each nostril no more than every 2 hours.

If symptoms are not improved after 3 consecutive days, consult a clinician. (See Overuse under Cautions.)

Adults

Nasal Congestion Intranasal

2 inhalations (0.4–0.5 mg) in each nostril no more than every 2 hours.

If symptoms are not improved after 3 consecutive days, consult a clinician. (See Overuse under Cautions.)

Prescribing Limits

Pediatric Patients

Nasal Congestion Intranasal

Children ≥6 years of age: Maximum of every 2 hours; maximum duration of 3 consecutive days.

Adults

Nasal Congestion Intranasal

Maximum of every 2 hours; maximum duration of 3 consecutive days.

Special Populations

No special populations dosage recommendations at this time.

Warnings

Warnings/Precautions

General Precautions

Overuse

Possible irritation of nasal mucosa and adverse systemic effects (particularly in children) with excessive dosage and/or prolonged or too frequent use. Possible rebound congestion (rhinitis, chronic redness and swelling of the nasal mucosa); avoid prolonged use. (See Advice to Patients.)

Overdosage following oral ingestion may result in psychotic reactions, palpitation, ventricular extrasystoles, and shock.

Sympathomimetic Effects

Possible headache, hypertension, nervousness, and increased ventricular rate. Use with caution in patients with thyroid disease (e.g., hyperthyroidism), heart disease, hypertension, or diabetes mellitus.

Specific Populations

Pregnancy

Safety during pregnancy not established.

Pediatric Use

Safety and efficacy not established in children <6 years of age.

Possible irritation of nasal mucosa and adverse systemic effects associated with excessive dosage, prolonged or too frequent use, or inadvertent ingestion of nasal solution.

Common Adverse Effects

Burning, stinging, sneezing, increase in nasal discharge.

What other drugs will affect Propylhexedrine

Specific Drugs

Drug

Interaction

Comments

MAO inhibitors

Potential for enhanced sympathomimetic effects

Interaction unlikely; however, use concomitantly with caution

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