Propylhexedrine
Brand names: Benzedrex
Drug class:
Antineoplastic Agents
Usage of Propylhexedrine
Nasal Congestion
Self-medication for temporary relief of nasal congestion associated with the common cold, hay fever, or other allergies.
As effective as other topical vasoconstrictors.
Topical nasal decongestants often preferred for short-term treatment; oral agents preferred for prolonged treatment. (See Overuse under Cautions.)
Reduce swelling and facilitate visualization of nasal and pharyngeal membranes prior to surgery or diagnostic procedures.
Open obstructed eustachian ostia in patients with ear inflammation.
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How to use Propylhexedrine
Administration
Intranasal Administration
Administer topically to the nasal mucosa as an inhalation.
Avoid contamination of the inhaler tip; inhaler is for single-patient use only.
Warm drug container in the hands prior to use to increase drug volatility.
Inhale vapor through each nostril while head is erect; blow nose thoroughly after 3–5 minutes.
Supervise use by children 6–12 years of age.
Dosage
The Benzedrex propylhexedrine inhaler delivers 0.4–0.5 mg of the drug in each 800 mL of air.
Pediatric Patients
Nasal Congestion IntranasalChildren ≥6 years of age: 2 inhalations (0.4–0.5 mg) in each nostril no more than every 2 hours.
If symptoms are not improved after 3 consecutive days, consult a clinician. (See Overuse under Cautions.)
Adults
Nasal Congestion Intranasal2 inhalations (0.4–0.5 mg) in each nostril no more than every 2 hours.
If symptoms are not improved after 3 consecutive days, consult a clinician. (See Overuse under Cautions.)
Prescribing Limits
Pediatric Patients
Nasal Congestion IntranasalChildren ≥6 years of age: Maximum of every 2 hours; maximum duration of 3 consecutive days.
Adults
Nasal Congestion IntranasalMaximum of every 2 hours; maximum duration of 3 consecutive days.
Special Populations
No special populations dosage recommendations at this time.
Warnings
Warnings/Precautions
General Precautions
OverusePossible irritation of nasal mucosa and adverse systemic effects (particularly in children) with excessive dosage and/or prolonged or too frequent use. Possible rebound congestion (rhinitis, chronic redness and swelling of the nasal mucosa); avoid prolonged use. (See Advice to Patients.)
Overdosage following oral ingestion may result in psychotic reactions, palpitation, ventricular extrasystoles, and shock.
Sympathomimetic EffectsPossible headache, hypertension, nervousness, and increased ventricular rate. Use with caution in patients with thyroid disease (e.g., hyperthyroidism), heart disease, hypertension, or diabetes mellitus.
Specific Populations
PregnancySafety during pregnancy not established.
Pediatric UseSafety and efficacy not established in children <6 years of age.
Possible irritation of nasal mucosa and adverse systemic effects associated with excessive dosage, prolonged or too frequent use, or inadvertent ingestion of nasal solution.
Common Adverse Effects
Burning, stinging, sneezing, increase in nasal discharge.
What other drugs will affect Propylhexedrine
Specific Drugs
Drug
Interaction
Comments
MAO inhibitors
Potential for enhanced sympathomimetic effects
Interaction unlikely; however, use concomitantly with caution
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