Protein C Concentrate
Brand names: Ceprotin
Drug class:
Antineoplastic Agents , Antineoplastic Agents
Usage of Protein C Concentrate
Congenital Protein C Deficiency
Replacement therapy in patients with severe congenital protein C deficiency for prevention and treatment of venous thrombosis and purpura fulminans (designated an orphan drug by FDA for this use).
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How to use Protein C Concentrate
General
Administration
IV Administration
Administer by IV injection.
Initiate therapy under supervision of a clinician experienced in replacement therapy with coagulation factors/inhibitors and where monitoring of protein C activity is feasible.
Protein C (human) may be self-administered if clinician determines that the patient and/or caregiver is competent to safely administer the drug after appropriate training.
ReconstitutionPrior to reconstitution, allow lyophilized powder and manufacturer-supplied diluent to warm to room temperature.
Reconstitute lyophilized powder with diluent provided by manufacturer. Use strict aseptic technique since drug contains no preservative.
Reconstitute appropriate number of vials based on the indicated dosage. Vials contain approximately 500 or 1000 IU protein C (human); actual potency is labeled on each vial.
Reconstitute single-use vials of lyophilized powder by adding 5 or 10 mL of sterile water for injection to vial containing approximately 500 or 1000 units of protein C (human), respectively, using transfer needle provided by manufacturer; resulting solution contains approximately 100 units of protein C (human) per mL. Swirl vial gently until powder is completely dissolved.
Withdraw reconstituted solution from vial(s) using filter needle provided by manufacturer. Before administration, replace filter needle with a suitable needle or infusion set with winged adapter. Filter needle provided by manufacturer is intended to filter contents of a single vial.
Administer at room temperature within 3 hours of reconstitution.
Rate of AdministrationPatients weighing <10 kg: Inject at a maximum rate of 0.2 mL/kg per minute.
Patients weighing ≥10 kg: Inject at a maximum rate of 2 mL/minute.
Dosage
Potency of protein C (human) is determined by chromogenic assay and is expressed in international units (IU, units) as tested against the activity of the WHO reference standard.
One unit is approximately equivalent to the protein C activity (as measured by an amidolytic assay) present in 1 mL of plasma. The number of units of protein C is indicated on the label of each vial.
Pediatric Patients
Congenital Protein C Deficiency Treatment of Acute Episodes of Venous Thrombosis and Purpura Fulminans IVInitially, 100–120 units/kg, followed by 60–80 units/kg every 6 hours for 3 doses and a subsequent maintenance dosage of 45–60 units/kg every 6 or 12 hours.
Adjust dosage according to measured plasma protein C activity; initially maintain peak plasma protein C activity at 100% of normal. Following resolution of the acute event, maintain trough plasma protein C activity at a level above 25% of normal for the duration of treatment.
In patients initiating oral anticoagulant therapy, continue protein C replacement therapy until adequate anticoagulation is achieved. (See Specific Drugs under Interactions.)
Prophylaxis of Thrombotic Events IVShort-term prophylaxis: Initially, 100–120 units/kg, followed by 60–80 units/kg every 6 hours for 3 doses and a subsequent maintenance dosage of 45–60 units/kg every 6 or 12 hours.
Long-term prophylaxis (maintenance dosage): 45–60 units/kg every 12 hours; adjust dosage to maintain trough plasma protein C activity above 25% of normal. An increase in peak plasma protein C activity may be appropriate during periods of increased thrombotic risk (e.g., infection, trauma, surgery).
Adjust dosage according to measured plasma protein C activity; initially maintain peak plasma protein C activity at 100% of normal. Following resolution of the acute event, maintain trough plasma protein C activity at a level above 25% of normal for the duration of treatment.
In patients initiating oral anticoagulant therapy, continue protein C replacement therapy until adequate anticoagulation is achieved. (See Specific Drugs under Interactions.)
Adults
Congenital Protein C Deficiency Treatment of Acute Episodes of Venous Thrombosis and Purpura Fulminans IVInitially, 100–120 units/kg, followed by 60–80 units/kg every 6 hours for 3 doses and a subsequent maintenance dosage of 45–60 units/kg every 6 or 12 hours.
Adjust dosage according to measured plasma protein C activity; initially maintain peak plasma protein C activity at 100% of normal. Following resolution of the acute event, maintain trough plasma protein C activity at a level above 25% of normal for the duration of treatment.
In patients initiating oral anticoagulant therapy, continue protein C replacement therapy until adequate anticoagulation is achieved. (See Specific Drugs under Interactions.)
Prophylaxis of Thrombotic Events IVShort-term prophylaxis: Initially, 100–120 units/kg, followed by 60–80 units/kg every 6 hours for 3 doses and a subsequent maintenance dosage of 45–60 units/kg every 6 or 12 hours.
Long-term prophylaxis (maintenance dosage): 45–60 units/kg every 12 hours; adjust dosage to maintain trough plasma protein C activity above 25% of normal. An increase in peak plasma protein C activity may be appropriate during periods of increased thrombotic risk (e.g., infection, trauma, surgery).
Adjust dosage according to measured plasma protein C activity; initially maintain peak plasma protein C activity at 100% of normal. Following resolution of the acute event, maintain trough plasma protein C activity at a level above 25% of normal for the duration of treatment.
In patients initiating oral anticoagulant therapy, continue protein C replacement therapy until adequate anticoagulation is achieved. (See Specific Drugs under Interactions.)
Prescribing Limits
Pediatric Patients
Congenital Protein C Deficiency IVPatients weighing <10 kg: Inject at a maximum rate of 0.2 mL/kg per minute.
Patients weighing ≥10 kg: Inject at a maximum rate of 2 mL/minute.
Adults
Congenital Protein C Deficiency IVInject at a maximum rate of 2 mL/minute.
Special Populations
No special population dosage recommendations at this time.
Warnings
Contraindications
Warnings/Precautions
Sensitivity Reactions
Hypersensitivity ReactionPossible hypersensitivity reactions, including anaphylaxis. If hypersensitivity reaction occurs, discontinue immediately and institute appropriate therapy as indicated.
Possible allergic reactions to trace amounts of murine (mouse) protein and/or heparin.
Antibody FormationInhibiting antibodies to protein C (human) not observed in clinical studies; however, the potential for developing antibodies cannot be ruled out.
Risk of Transmissible Agents in Plasma-derived Preparations
Potential vehicle for transmission of human viruses (i.e., HIV, hepatitis A [HAV], hepatitis B [HBV], hepatitis C [HCV], parvovirus B19) and other infectious agents.
Improved donor screening, viral-inactivating procedures (e.g., solvent/detergent, heat treatment), and/or immunoaffinity chromatography procedures have reduced but not completely eliminated risk of pathogen transmission with plasma-derived protein C (human) preparations. Some viruses (e.g., human parvovirus B19, HAV) are difficult to remove or inactivate.
Human parvovirus B19 infection is most serious in pregnant women (fetal infection) or immunocompromised patients.
Consider vaccination (against HAV and HBV infection) for patients who routinely or repeatedly receive protein C (human).
Theoretical possibility of transmitting causative agent of Creutzfeldt-Jakob disease (CJD).
Report suspected infections to the manufacturer at 866-888-2472.
Bleeding
Severe bleeding reported; may be associated with concomitant use of anticoagulants. (See Specific Drugs under Interactions.)
Heparin-induced Thrombocytopenia
Possible heparin-induced thrombocytopenia (HIT) due to trace amounts of heparin contained in protein C (human) preparations.
If HIT occurs, immediately determine platelet count and consider discontinuance of protein C (human).
Sodium Content
The quantity of sodium in the maximum daily dosage of protein C (human) exceeds 200 mg.
Specific Populations
PregnancyCategory C.
LactationNot known whether protein C (human) is distributed into milk in humans.
Pediatric UseSafety and efficacy established in children ≥2 days of age.
Pharmacokinetics not established in pediatric patients. However, systemic exposure may be reduced in very young children compared with older individuals; consider this fact when selecting a dosage regimen for children. (See Pediatric Patients under Dosage and Administration and see Special Populations under Pharmacokinetics.)
Geriatric UseExperience in patients ≥65 years of age is insufficient to determine whether they respond differently than younger adults.
Hepatic ImpairmentSafety and efficacy not established in patients with hepatic impairment.
Renal ImpairmentSafety and efficacy not established in patients with renal impairment.
Monitor closely for sodium overload. (See Sodium Content under Cautions.)
Common Adverse Effects
Hypersensitivity reactions (e.g., itching, rash), lightheadedness.
What other drugs will affect Protein C Concentrate
No formal drug interaction studies performed to date.
Specific Drugs
Drug
Interaction
Comments
Anticoagulants, oral
Risk of transient hypercoagulable state (before desired anticoagulant effect is achieved) with initiation of concomitant therapy because protein C (human) has a shorter half-life than most vitamin K-dependent proteins (i.e., factors II, IX, and X), which leads to more rapid suppression of activity of protein C (human) than that of the procoagulant factors
Increased risk of warfarin-induced skin necrosis in patients with severe congenital protein C deficiency
Possible increased risk of bleeding
When switching to oral anticoagulation, continue protein C (human) replacement therapy until adequate anticoagulation is achieved
Initiate oral anticoagulant at a low dosage, followed by incremental dosage adjustments; standard anticoagulant loading dose not recommended
Thrombolytics (e.g., alteplase, reteplase, tenecteplase)
Increased risk of bleeding
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