Provayblue injection

Generic name: Methylene Blue (injection)
Brand names: Provayblue

Usage of Provayblue injection

Methemoglobin is a form of hemoglobin (HEEM o glo bin). Hemoglobin is a substance in blood that carries oxygen and distributes it to your tissues and organs. However, methemoglobin is not a type of hemoglobin that is useful in carrying oxygen.

Methemoglobin normally exists in small amounts in the blood. However, when methemoglobin levels increase, the blood is less efficient in circulating oxygen. The resulting lack of oxygen throughout the body can cause symptoms such as pale or blue-colored skin.

Methemoglobinemia is a condition in which methemoglobin is present in high levels in the blood. Methemoglobinemia can occur when a person is exposed to certain drugs or chemicals such as nitrites.

Provayblue is used to treat methemoglobinemia. Provayblue works by converting methemoglobin to a more efficient type of hemoglobin to better carry oxygen throughout the body.

Provayblue may also be used for purposes not listed in this medication guide.

Provayblue injection side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

  • confusion or weakness;
  • pale or yellowed skin;
  • dark colored urine;
  • fever; or
  • high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.
  • Common side effects of Provayblue may include:

  • pain in your arms or legs;
  • blue or green urine;
  • altered sense of taste;
  • headache, dizziness;
  • sweating, skin discoloration;
  • nausea; or
  • feeling hot.
  • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Provayblue injection

    You should not be treated with Provayblue if you are allergic to it, or if you have:

  • a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
  • Many drugs can interact with Provayblue. Tell your doctor about all your current medicines and any you recently stopped using, especially:

  • alfentanil, fentanyl;
  • buspirone;
  • digoxin, digitalis;
  • dihydroergotamine, ergotamine;
  • phenytoin;
  • pimozide;
  • quinidine;
  • warfarin (Coumadin, Jantoven);
  • an MAO inhibitor--isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, tranylcypromine, and others;
  • an "SSRI" antidepressant--citalopram, escitalopram, fluoxetine, paroxetine, sertraline, Prozac, Paxil, Zoloft, and others;
  • an "SNRI" antidepressant--desvenlafaxine, duloxetine, levomilnacipran, milnacipran, venlafaxine, Effexor, Cymbalta, Pristiq, and others;
  • other antidepressants--bupropion, clomipramine, mirtazapine; or
  • medicine to prevent organ transplant rejection--cyclosporine, sirolimus, tacrolimus.
  • To make sure Provayblue is safe for you, tell your doctor if you have:

  • liver disease; or
  • kidney disease.
  • Using Provayblue during pregnancy could harm the unborn baby. Tell your doctor if you are pregnant.

    Do not breast-feed within 8 days after you received Provayblue. If you use a breast pump during this time, throw out any milk you collect. Do not feed it to your baby.

    How to use Provayblue injection

    Provayblue is injected into a vein through an IV. A healthcare provider will give you this injection. The IV infusion can take up to 30 minutes to complete.

    Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely while you are receiving Provayblue. Your blood will also need to be tested to help your doctor determine that the medicine is working.

    You may only need to receive one dose of Provayblue. If you do need a second dose, it can be given 1 hour after your first dose.

    Provayblue will most likely cause your urine or stools to appear blue or green in color. This is a normal side effect of the medication and will not cause any harm. However, this effect may cause unusual results with certain urine tests.

    Warnings

    You should not be treated with Provayblue if you have glucose-6-phosphate dehydrogenase (G6PD) deficiency.

    Many drugs can interact with Provayblue. Tell your doctor about all your current medicines and any you recently stopped using, especially an antidepressant.

    What other drugs will affect Provayblue injection

    Many drugs can interact with Provayblue, and some drugs should not be used together. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all medicines you use, and those you have recently used before your treatment with this medicine.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

    Popular Keywords