Pyrukynd

Generic name: Mitapivat
Dosage form: tablets, for oral use
Drug class: Miscellaneous metabolic agents

Usage of Pyrukynd

Pyrukynd is a prescription medicine used to treat low red blood cell counts caused by the early breakdown of red blood cells (hemolytic anemia) in adults with pyruvate kinase deficiency (PK Deficiency).

It is not known if Pyrukynd is safe and effective in children.

Pyrukynd side effects

Pyrukynd may cause serious side effects, including:

  • Rapid breakdown of red blood cells (acute hemolysis) has happened after suddenly interrupting or stopping treatment. You should not suddenly stop taking Pyrukynd. If you have to stop your treatment, your healthcare provider should monitor you closely. Tell your healthcare provider right away if you develop any signs or symptoms of breakdown of red blood cells including:
  • yellowing of the skin or the whites of your eyes (jaundice)
  • dark colored urine
  • dizziness
  • confusion
  • feeling tired
  • shortness of breath

    • The most common side effects include:

  • decrease in reproductive hormone (estrone) in men
  • increased salt from uric acid (urate) blood test
  • decrease in reproductive hormone (estradiol) in men
  • joint pain (arthralgia)
  • back pain

    • These are not all of the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Pyrukynd

    Before you start treatment, tell your healthcare provider about all your medical conditions, including if you:

  • have liver problems.
  • are pregnant or plan to become pregnant. It is not known if Pyrukynd will harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think that you are pregnant during treatment.
  • are breastfeeding or plan to breastfeed. It is not known if Pyrukynd passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby during treatment.

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    How to use Pyrukynd

    Usual Adult Dose for Pyruvate Kinase Deficiency

    - Starting dosage: 5 mg orally twice daily with or without food. See table below for dose titration and taper schedule.

    - Use: treatment of hemolytic anemia in adults with pyruvate kinase (PK) deficiency

    Duration Dosage Week 1 through Week 4 5 mg twice daily Week 5 through Week 8

    If Hb is below normal range or patient has required a transfusion within the last 8 weeks:

  • Increase to 20 mg twice daily and maintain for 4 weeks.

    • If Hb is within normal range and patient has not required a transfusion within the last 8 weeks:

  • Maintain 5 mg twice daily.
    • Week 9 through Week 12

    If Hb is below normal range or patient has required a transfusion within the last 8 weeks:

  • Increase to 50 mg twice daily and maintain thereafter.

    • If Hb is within normal range and patient has not required a transfusion within the last 8 weeks:

  • Maintain current dose (5 mg twice daily or 20 mg twice daily).
    • Maintenance If Hb decreases, consider up-titration to the maximum of 50 mg twice daily as per the above schedule.

    What other drugs will affect Pyrukynd

    Tell your healthcare provider about all the medicines that you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Pyrukynd and certain other medicines may affect each other causing side effects. Pyrukynd may affect the way other medicines work, and other medicines may affect how Pyrukynd works.

    Know the medicines you take. Keep a list of them to show your healthcare provider or pharmacist when you get a new medicine.

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