Qinlock

Generic name: Ripretinib
Drug class: Multikinase inhibitors

Usage of Qinlock

Qinlock is an enzyme inhibitor that blocks the action of protein kinases.

Qinlock is a prescription medicine used to treat tumors of the stomach and intestines, specifically adults with advanced gastrointestinal stromal tumor (GIST).

Qinlock is for use in adults who have already been treated with at least 3 other cancer medicines.

Qinlock side effects

Get emergency medical help if you have signs of an allergic Reaction to Qinlock: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

severe stomach pain, nausea, or vomiting;

severe headache, blurred vision, pounding in your neck or ears;

pain, blisters, bleeding, or severe rash in the palms of your hands or the soles of your feet;

heart problems - tiredness, feeling short of breath, swollen veins in the sides of your neck, swelling in your stomach or lower legs;

low red blood cells (anemia) - pale skin, unusual tiredness, feeling light-headed or short of breath, cold hands and feet; or

skin changes - a new wart, a skin sore or red bump that bleeds or does not heal, or any change in the size or color of a mole.

Common Qinlock side effects may include:

nausea, vomiting, stomach pain, loss of appetite;

diarrhea, constipation;

tiredness;

muscle pain; or

thinning hair, hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Qinlock

You may not be able to use Qinlock if you have untreated or uncontrolled hypertension (high blood pressure).

To make sure Qinlock is safe for you, tell your doctor if you have ever HAD:

skin problem called palmar-plantar erythrodysesthesia syndrome;

high blood pressure;

heart problems; or

if you have recently had surgery or plan to have surgery.

Using Qinlock may increase your risk of developing skin cancer. Your skin may need to be checked while you are using this medicine. Ask your doctor about skin symptoms to watch for.

You may need to have a negative pregnancy test before starting this treatment.

Both men and women using this medicine should use effective birth control to prevent pregnancy. Ripretinib can harm an unborn baby if the mother or father is using this medicine.

Use effective birth control to prevent pregnancy while you are using this medicine and for at least 1 week after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Qinlock.

This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because ripretinib can harm an unborn baby.

Do not breastfeed while using this medicine, and for at least 1 week after your last dose.

Relate drugs

How to use Qinlock

Usual Adult Dose for Gastrointestinal Stromal Tumor:

150 mg orally once daily until disease progression or uNACceptable toxicity Use: For adults with advanced gastrointestinal stromal tumor (GIST) who have received prior treatment with 3 or more kinase inhibitors, including Imatinib

Warnings

Qinlock may affect fertility in males which may affect the ability to have children. Talk to your healthcare provider if this is a concern for you.

Qinlock and certain other medicines can affect each other causing side effects or affect how ripretinib works. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What other drugs will affect Qinlock

Sometimes it is not safe to use certain medications at the SAMe time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your other medicines, especially blood pressure medicine.

Other drugs may interact with ripretinib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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