Qudexy XR

Generic name: Topiramate
Drug class: Carbonic anhydrase inhibitor anticonvulsants

Usage of Qudexy XR

Topiramate is used alone or together with other medicines to help treat certain types of seizures (eg, partial seizures, tonic-clonic seizures, or Lennox-Gastaut syndrome). This medicine will not cure epilepsy and will only work to control seizures for as long as you continue to take it. It is also used to help prevent migraine headaches.

This medicine is available only with your doctor's prescription.

Qudexy XR side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Blurred vision

burning, prickling, or tingling sensations

clumsiness or unsteadiness

confusion

continuous, uncontrolled back-and-forth or rolling eye movements

dizziness

double vision

drowsiness

eye redness or pain

generalized slowing of mental and physical activity

increased eye pressure

memory problems

menstrual changes or pain

nervousness

speech or language problems

trouble in concentrating or paying attention

unusual tiredness or weakness

Less common

Aggression

agitation

chest pain

chills

discouragement

feeling sad or empty

fever

irritability

lack of feeling or emotion

lessening of sensations or perception

loss of appetite

loss of interest or pleasure

red, irritated, or bleeding gums

sore throat

stomach pain

trouble sleeping

weight loss

Rare

Blood in the urine

difficult or painful urination

frequent urination

hearing loss

itching, skin rash

loss of bladder control

lower back or side pain

nosebleeds

pale skin

ringing or buzzing in the ears

swelling

trouble breathing

Incidence not known

Blistering, peeling, or loosening of the skin

bloating

bone fractures, especially of the thigh bone

bone pain, tenderness, or aching

clay-colored stools

constipation

cough

decrease in height

diarrhea

increased rate of breathing

joint or muscle pain

muscle weakness

pain in the back, ribs, arms, or legs

pain or tenderness in the upper stomach

red skin lesions, often with a purple center

sores, ulcers, or white spots in the mouth or on the lips

yellow eyes or skin

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Decreased awareness or responsiveness

dizziness, fainting, or lightheadedness when getting up suddenly from a lying or sitting position

severe sleepiness

unusual drowsiness, dullness, or feeling of sluggishness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Breast pain in women

tremors

Less common

Constipation

feeling of warmth

heartburn

increased sweating

redness of the face, neck, arms, and occasionally, upper chest

Rare

Decrease in sexual performance or desire

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Qudexy XR

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever HAD any unusual or allergic Reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of topiramate capsules, oral solution, or tablets, or Qudexy® extended-release capsules to treat seizures in children younger than 2 years of age (when used alone or together with other medicines). However, children are more likely to have unwanted effects (eg, rickets, slow growth, and increased risk of kidney stones) to this medicine. Safety and efficacy have not been established.

Appropriate studies have not been performed on the relationship of age to the effects of Trokendi™ extended-release capsules for the treatment of seizures in children younger than 6 years of age.

Appropriate studies have not been performed on the relationship of age to the effects of topiramate capsules, extended-release capsules, tablets, or oral solution for the prevention of migraine headaches in children younger than 12 years of age. Safety and efficacy have not been established.

Geriatric

Although appropriate studies on the relationship of age to the effects of topiramate have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of topiramate in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving topiramate.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acepromazine

Acetazolamide

Alfentanil

Alprazolam

Amitriptyline

Amobarbital

Anileridine

Apixaban

Aripiprazole

Aripiprazole Lauroxil

Asenapine

Baclofen

Benperidol

Benzhydrocodone

Brinzolamide

Bromazepam

Buprenorphine

Buspirone

Butabarbital

Butorphanol

Calcifediol

Calcium Oxybate

Cannabidiol

Cannabis

Carbamazepine

Carbinoxamine

Carisoprodol

Carphenazine

Cetirizine

Chloral Hydrate

Chlordiazepoxide

Chlorpromazine

Chlorzoxazone

Citalopram

Clobazam

Clonazepam

Clorazepate

Clozapine

Codeine

Cyclobenzaprine

Daridorexant

DesOgestrel

Dexmedetomidine

Diacetylmorphine

Diazepam

Dichloralphenazone

Dichlorphenamide

Dienogest

Difenoxin

Dihydrocodeine

Diphenhydramine

Diphenoxylate

Dorzolamide

Doxylamine

Droperidol

Drospirenone

Enflurane

Esketamine

Estazolam

Estetrol

Estradiol

Eszopiclone

Ethchlorvynol

Ethinyl Estradiol

Ethopropazine

Ethylmorphine

Ethynodiol

Etonogestrel

Fentanyl

Flibanserin

Flunitrazepam

Fluphenazine

Flurazepam

Fluspirilene

Fosphenytoin

Fospropofol

Gabapentin

NACarbil" href="/drugs/gabapentin-enacarbil-6032/">Gabapentin enacarbil

Gestodene

Halazepam

Haloperidol

Halothane

Hexobarbital

Hydrochlorothiazide

Hydrocodone

Hydromorphone

Hydroxyzine

Isoflurane

Ketamine

Ketazolam

Ketobemidone

Lacosamide

Lemborexant

Levocetirizine

Levonorgestrel

Levorphanol

Lithium

Lofexidine

Lorazepam

Loxapine

Magnesium Oxybate

Meclizine

Medroxyprogesterone

Melperone

Meperidine

Mephobarbital

Meprobamate

Meptazinol

Mesoridazine

Mestranol

Metaxalone

Metformin

Methadone

Methazolamide

Methdilazine

Methocarbamol

Methohexital

Methotrimeprazine

Methylene Blue

Metoclopramide

Midazolam

Molindone

Moricizine

Morphine

Morphine Sulfate Liposome

Nalbuphine

Nicomorphine

Nifedipine

Nitrazepam

Nitrous Oxide

Nomegestrol

Norelgestromin

Norethindrone

Norgestimate

Norgestrel

Olanzapine

Opium

Opium Alkaloids

Orlistat

Orphenadrine

Oxazepam

Oxycodone

Oxymorphone

Papaveretum

Paregoric

Pentazocine

Pentobarbital

Perampanel

Perazine

Periciazine

Perphenazine

Phenytoin

Pimozide

Pioglitazone

Piperacetazine

Piperaquine

Pipotiazine

Piritramide

Potassium Oxybate

Prazepam

Pregabalin

Primidone

Prochlorperazine

Promazine

Promethazine

Propofol

Quazepam

Quetiapine

Ramelteon

Remifentanil

Remimazolam

Remoxipride

Rivaroxaban

Ropeginterferon Alfa-2b-njft

Scopolamine

Secobarbital

Segesterone

Sertindole

Sodium Oxybate

Sufentanil

Sulpiride

Suvorexant

Tapentadol

Temazepam

Thiethylperazine

Thiopental

Thiopropazate

Thioridazine

Tilidine

Tizanidine

Tolonium Chloride

Tramadol

Trazodone

Triazolam

Trifluoperazine

Trifluperidol

Triflupromazine

Trimeprazine

Ulipristal

Valproic acid

Venlafaxine

Zaleplon

Zolpidem

Zopiclone

Zotepine

Zuranolone

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Ginkgo

Phenobarbital

Posaconazole

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is not recommended. Your doctor may decide not to treat you with this medication, change some of the other medicines you take, or give you special instructions about the use of food, alcohol, or tobacco.

Ethanol

Relate drugs

How to use Qudexy XR

Take this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered.

This medicine comes with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Topiramate may be taken with or without food.

Swallow the Trokendi XR™ extended-release capsule whole. Do not open, crush, or chew the capsule.

Measure the Eprontia™ oral solution with a marked measuring spoon, oral syringe, or medicine cup.

Avoid drinking alcohol with Eprontia™, Qudexy® XR, or Topamax®, or avoid for 6 hours before and 6 hours after taking the Trokendi XR™ capsule.

Swallow the tablet whole. Do not break, crush, or chew it. The tablet may taste bitter if it is held in the mouth or chewed.

The Topamax® sprinkle capsule or Qudexy® XR extended-release capsule may be swallowed whole or opened and sprinkled on a small amount (1 teaspoon) of soft food (eg, applesauce). Swallow the food mixture right away without chewing. Do not save for later use.

Drink extra water with this medicine to help prevent kidney stones.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral doSage form (extended-release capsules):

For seizures (taken with other medicines):

Adults—At first, 25 to 50 milligrams (mg) once a day. Your doctor may adjust the dose as needed. However, the dose is usually not more than 400 mg per day.

Children—

Qudexy®:

Children 2 years of age and older—Dose is based on body weight and must be determined by your doctor. The usual starting dose is 25 milligrams (mg) once a day in the evening. Your doctor may adjust the dose as needed. However, the dose is usually not more than 5 to 9 mg per kilogram (kg) of body weight per day.

Children younger than 2 years of age—Use is not recommended.

Trokendi™:

Children 6 years of age and older—At first, 25 milligrams (mg) once a day in the evening. Your doctor may adjust the dose as needed. However, the dose is usually not more than 5 to 9 mg per kilogram (kg) of body weight per day.

Children younger than 6 years of age—Use is not recommended.

For seizures (taken alone):

Qudexy®:

Adults and children 10 years of age and older—At first, 50 milligrams (mg) once a day. Your doctor may increase the dose as needed. However, the dose is usually not more than 400 mg per day.

Children 2 to 10 years of age—Dose is based on body weight and must be determined by your doctor. The starting dose is usually 25 mg once a day, in the evening. Your doctor may increase the dose as needed and tolerated. However, the dose is usually not more than 400 mg per day.

Children younger than 2 years of age—Use and dose must be determined by your doctor.

Trokendi™:

Adults and children 10 years of age and older—At first, 50 milligrams (mg) once a day. Your doctor may adjust the dose as needed. However, the dose is usually not more than 400 mg per day.

Children younger than 10 years of age—Use and dose must be determined by your doctor.

For migraine headaches:

Adults and children 12 years of age and older—At first, 25 milligrams (mg) once a day. Your doctor may adjust the dose as needed. However, the dose is usually not more than 100 mg per day.

Children younger than 12 years of age—Use and dose must be determined by your doctor.

For oral dosage forms (capsules or tablets):

For seizures (taken with other medicines):

Adults and children 17 years of age and older—At first, 25 or 50 milligrams (mg) once a day. Your doctor may adjust the dose as needed. However, the dose is usually not more than 400 mg per day.

Children 2 to 16 years of age—Dose is based on body weight and must be determined by your child's doctor. The starting dose is usually 25 milligrams (mg) once a day in the evening. The doctor may adjust the dose as needed.

Children younger than 2 years of age—Use and dose must be determined by your doctor.

For seizures (taken alone):

Adults and children 10 years of age and older—At first, 50 milligrams (mg) per day, taken in 2 divided doses. Your doctor may adjust the dose as needed. However, the dose is usually not more than 400 mg per day.

Children 2 to 9 years of age—Dose is based on body weight and must be determined by your child's doctor. The starting dose is usually 25 mg once a day in the evening. The doctor may adjust the dose as needed. However, the dose is usually not more than 250 to 400 mg per day.

Weighing more than 38 kilograms (kg)—250 to 400 mg per day taken in 2 divided doses.

Weighing 32 to 38 kg—250 to 350 mg per day taken in 2 divided doses.

Weighing 23 to 31 kg—200 to 350 mg per day taken in 2 divided doses.

Weighing 12 to 22 kg—200 to 300 mg per day taken in 2 divided doses.

Weighing 11 kg or less—150 to 250 mg per day taken in 2 divided doses.

Children younger than 2 years of age—Use and dose must be determined by your doctor.

For migraine headaches:

Adults and children 12 years of age and older—At first, 25 milligrams (mg) once a day in the evening. Your doctor may adjust the dose as needed. However, the dose is usually not more than 100 mg per day.

Children younger than 12 years of age—Use and dose must be determined by your doctor.

For oral dosage forms (solution):

For seizures (taken with other medicines):

Adults and children 17 years of age and older—At first, 25 or 50 milligrams (mg) once a day. Your doctor may adjust the dose as needed. However, the dose is usually not more than 400 mg per day.

Children younger than 2 years of age—Use and dose must be determined by your doctor.

For seizures (taken alone):

Weighing more than 38 kilograms (kg)—250 to 400 mg per day taken in 2 divided doses.

Weighing 32 to 38 kg—250 to 350 mg per day taken in 2 divided doses.

Weighing 23 to 31 kg—200 to 350 mg per day taken in 2 divided doses.

Weighing 12 to 22 kg—200 to 300 mg per day taken in 2 divided doses.

Weighing 11 kg or less—150 to 250 mg per day taken in 2 divided doses.

Children younger than 2 years of age—Use and dose must be determined by your doctor.

For migraine headaches:

Children younger than 12 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

If your next regular dose of Topamax® capsule or tablet or Eprontia™ oral solution is within 6 hours away, wait until then to use the medicine and skip the missed dose.

If you miss more than 1 dose of Topamax® capsule or tablet orEprontia™ oral solution, contact your doctor for instructions about how to restart it.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Throw away any unused Eprontia™ oral solution 60 days after first opening.

Warnings

It is very important that your doctor check your or your child's progress at regular visits to see if the medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away.

Birth control pills containing estrogen may not work properly if you take them with topiramate. To keep from getting pregnant, use an additional form of birth control (eg, condoms, spermicide) together with your birth control pill. If you have any questions about this, check with your doctor or pharmacist.

This medicine may cause vision changes, clumsiness or unsteadiness, dizziness, drowsiness, or trouble with thinking or speaking. Make sure you know how you or your child react to this medicine before you drive, use machines, climb in high places, swim, or do anything else that could be dangerous if you are not alert, well-coordinated, or able to think or see well.

Check with your doctor before using this medicine with alcohol or other medicines that affect the central nervous system. The use of alcohol or other medicines that affect the CNS with topiramate may worsen the side effects of this medicine, such as dizziness, poor concentration, drowsiness, unusual dreams, and trouble with sleeping. Some examples of medicines that affect the CNS are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicines, medicine for depression, medicine for anxiety, prescription pain medicine or narcotics, medicine for attention deficit and hyperactivity disorder, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics.

Check with your doctor right away if you or your child have changes in vision or pain around the eyes during and after treatment with this medicine. Your doctor may want your eyes to be checked by an ophthalmologist (eye doctor).

This medicine may make you sweat less which will cause your body temperature to increase. Use extra care not to become overheated during exercise or hot weather with this medicine. Overheating may result in heat stroke and hot baths or saunas may make you dizzy or feel faint.

Topiramate may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. Make sure the doctor knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell the doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. If you, your child, or your caregiver notice any of these side effects, tell your doctor right away.

This medicine may cause nausea, muscle tremors, breathing problems, eating problems, a fast heartbeat, restlessness, and stomach pain. Tell your doctor right away if you or your child have any of these symptoms. You might have a serious condition called metabolic acidosis (too much acid in the blood).

This medicine may decrease the density of bones, which can make your bones weak. Talk with your doctor if you have any concerns about this.

This medicine may cause slow growth. For children, the doctor will need to keep track of height and weight to make sure that the child is growing properly.

Do not suddenly stop using this medicine without checking first with your doctor. Stopping the medicine suddenly may cause your seizures to return or to occur more often. Your doctor may want you or your child to gradually reduce the amount you are using before stopping it completely.

Serious skin reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis) can occur with Topamax® and Eprontia™. Check with your doctor right away if you have blistering, peeling, or loosening of the skin, chills, cough, diarrhea, itching, joint or muscle pain, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, or white spots in the mouth or on the lips, or unusual tiredness or weakness with this medicine.

Check with your doctor right away if you or your child are having unusual drowsiness, dullness, tiredness, weakness, feelings of sluggishness, mental depression or anxiety, nightmares or unusually vivid dreams, or vomiting. These may be symptoms of a serious condition called hyperammonemic encephalopathy.

Check with your doctor right away if you or your child have sudden back pain, stomach pain, pain while urinating, or bloody or dark urine. These may be symptoms of kidney stones.

Tell your doctor if your or your child's skin feels like it is burning, crawling, itching, or if you have numbness, prickling, "pins and needles", or tingling feeling after using topiramate.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Qudexy XR

Usage of Qudexy XR

Qudexy XR side effects

Before taking Qudexy XR

Allergies

Pediatric

Geriatric

Breast Feeding

Interactions with Medicines

Interactions with Food/Tobacco/Alcohol

Other Medical Problems

Relate drugs

How to use Qudexy XR

Dosing

Missed Dose

Storage

Warnings

Disclaimer

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