Queen's Delight

Generic name: Stillingia Sylvatica Garden Ex L.
Brand names: Cockup-hat, Indian Flea Root, Marcory, Nettle Potato, Queen's Delight, Queen's Root, Silverleaf, Stillingia, Yaw-root

Usage of Queen's Delight

Studies have been conducted with prostratin.

Antiretroviral effects (of prostratin)

Animal and in vitro data

Prostratin has been identified in the plant, with synthetic versions of the protein kinase C activator being evaluated in studies. Prostratin appears to induce HIV expression from latent CD4+ T cells in HIV-infected individuals, with the potential to then enhance elimination, alone and in combination with other compounds.(Archin 2014, Beans 2013, Rochat 2017) Through activation of protein kinase C, it is able to inhibit HIV infection through downregulation of the HIV cellular entry receptors CD4 and CXCR4, and possibly CCR5.(Andersen 2018)

Chemotherapeutic effects (of prostratin)

Animal and in vitro data

Prostratin has been demonstrated to inhibit the growth of myeloid leukemia cells.(Shen 2015) In an in vitro study, prostratin was found to exert selective cytotoxicity against breast cancer cell lines. It inhibited CSCR4 expression through downregulation of SIK3 expression.(Alotaibi 2018)

Prostratin blocks HIV infection by downregulating the HIV cellular entry receptors CD4 and CXCR4, and possibly CCR5

Queen's Delight side effects

Do not ingest or use topically in human medicine. Observe particular caution with the fresh root, which appears to be more toxic than the dried product. Stillingia root is a purgative and irritant product that should be avoided because of a high likelihood of tumor promotion and documented severe irritancy to skin.Adolf 1980

Before taking Queen's Delight

Documented adverse effects. Not to be used while nursing.McGuffin 1997 Avoid use.

How to use Queen's Delight

There is no clinical evidence to support specific doSage recommendations for queen's delight. Classical use of queen's delight called for 2 g of the root, however the presence of irritant and potentially cytotoxic phorbol esters in this plant contraindicates therapeutic use.Adolf 1980

Warnings

Information is lacking. The presence of phorbols (protein kinase C activator) suggests mUTAgenicity is possible.Adolf 1980

What other drugs will affect Queen's Delight

None well documented. Caution may be warranted with concomitant anti-HIV medicines.

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