Ranolazine

Generic name: Ranolazine
Drug class: Antianginal agents

Usage of Ranolazine

Ranolazine is used in adults to treat chronic angina (chest pain). Ranolazine is not for use during an acute (emergency) attack of angina.

Ranolazine may also be used for purposes not listed in this medication guide.

Ranolazine side effects

Get emergency medical help if you have signs of an allergic Reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Ranolazine may cause serious side effects. Call your doctor at once if you have:

  • a light-headed feeling;
  • fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out); or
  • kidney problems--swelling, urinating less, feeling tired or short of breath.

    • Common side effects of ranolazine may include:

  • nausea, constipation;
  • headache; or
  • dizziness.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Ranolazine

    You should not take ranolazine if you are allergic to it, or if you have:

  • cirrhosis of the liver.

    • Some drugs should not be used with ranolazine. Your treatment plan may change if you also use:

  • clarithromycin;
  • Nefazodone;
  • St. John's wort;
  • antifungal medicine--itraconazole, ketoconazole;
  • HIV or AIDS medicine--Indinavir, lopinavir/ritonavir, Nelfinavir, ritonavir, Saquinavir;
  • seizure medicine--Carbamazepine, phenobarbital, phenytoin; or
  • tuberculosis medicine--rifabutin, rifampin, rifapentine.

    • Tell your doctor if you have ever had:

  • long QT syndrome (in you or a family member);
  • liver disease; or
  • kidney disease.

    • Tell your doctor if you are pregnant or breastfeeding.

    Relate drugs

    How to use Ranolazine

    Usual Adult Dose for Angina Pectoris:

    500 mg orally twice a day; increase to 1000 mg orally twice a day as neededMaximum dose: 1000 mg orally twice a dayUse: Treatment of chronic angina

    Warnings

    You should not take ranolazine if you have cirrhosis of the liver.

    Tell your doctor about all your other medicines. Some drugs should not be used with ranolazine.

    What other drugs will affect Ranolazine

    Tell your doctor about all your current medicines. Many drugs can affect ranolazine, especially:

  • any other medicine to treat heart disease;
  • an antibiotic or antifungal medicine;
  • oral diabetes medicine;
  • medicine to prevent organ transplant rejection;
  • medicine to treat a mental illness; or
  • medicine to treat or prevent nausea and vomiting caused by chemotherapy or radiation.

    • This list is not complete and many other drugs may affect ranolazine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

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