Reclast
Generic name: Zoledronic Acid
Drug class:
Bisphosphonates
Usage of Reclast
Reclast (sometimes called zoledronate) is a bisphosphonate medicine that alters bone formation and breakdown in the body. This can slow bone loss and may help prevent bone fractures.
Reclast is used to treat or prevent osteoporosis caused by menopause, or steroid use. This medicine also increases bone mass in men with osteoporosis. Reclast is for use when you have a high risk of bone fracture.
Reclast is also used to treat Paget's disease of bone.
Zometa is another brand of zoledronic acid used to treat high blood levels of calcium caused by cancer (also called hypercalcemia of malignancy). This medicine also treats multiple myeloma (a type of bone marrow cancer) or bone cancer that has spread from elsewhere in the body. You should not use Reclast and Zometa at the same time.
Reclast side effects
Get emergency medical help if you have signs of an allergic reaction to Reclast: hives; wheezing, chest tightness, trouble breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
Serious side effects on the kidneys may be more likely in older adults.
Common Reclast side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Reclast
You should not be treated with Reclast if you are allergic to zoledronic acid.
You also should not receive Reclast if you have:
You should not be treated with Reclast if are currently using any other bisphosphonate (such as alendronate, etidronate, ibandronate, pamidronate, risedronate, or tiludronate).
To make sure Reclast is safe for you, tell your doctor if you have ever had:
Zoledronic acid can cause serious kidney problems, especially if you are dehydrated, if you take diuretic medicine, or if you already have kidney disease.
This medicine may cause jaw bone problems (osteonecrosis). The risk is highest in people with cancer, blood cell disorders, pre-existing dental problems, or people treated with steroids, chemotherapy, or radiation. Ask your doctor about your own risk.
You may need to have a negative pregnancy test before starting treatment with Reclast.
Do not use Reclast if you are pregnant. Zoledronic acid may harm an unborn baby or cause birth defects. Zoledronic acid can remain in your body for weeks or years after your last dose. Use effective birth control to prevent pregnancy while using this medicine. Talk with your doctor about the need to prevent pregnancy after you stop using Reclast.
This medicine may affect fertility (ability to have children) in women. However, it is important to use birth control to prevent pregnancy because zoledronic acid can harm an unborn baby.
You should not breastfeed while using Reclast.
Relate drugs
- Aclasta
- Actonel
- Actonel with Calcium
- Alendronate
- Alendronate and cholecalciferol
- Aredia
- Atelvia
- Binosto
- Boniva
- Boniva (Ibandronate Intravenous)
- Boniva (Ibandronate Oral)
- Didronel
- Etidronate
- Fosamax
- Fosamax Plus D
- Ibandronate (Intravenous)
- Ibandronate (Oral)
- Ibandronate oral/injection
- Pamidronate
- Reclast
- Risedronate
- Skelid
- Tiludronate
- Zoledronic acid
- Zometa
How to use Reclast
Usual Adult Dose for Paget's Disease:
5 mg IV infusion, at a constant infusion rate, over no less than 15 minutes Calcium and vitamin D supplementation: -Calcium: 750 mg elemental calcium orally twice a day, or 500 mg orally three times a day -Vitamin D: 800 international units orally daily, especially in the 2 weeks following drug administration Comments: Retreatment may be considered in patients who have relapsed, based on increases in serum alkaline phosphatase or failure to achieve normalization of serum alkaline phosphatase. Uses: Paget's disease of bone with elevations in serum alkaline phosphatase of two times or higher than upper limit of age- specific normal reference range
Usual Adult Dose for Osteoporosis:
5 mg IV infusion over no less than 15 minutes, once a year Comments: An average of at least 1200 mg calcium and 800 to 1000 international units vitamin D daily is recommended. Uses: -Osteoporosis in postmenopausal women, diagnosed by bone mineral density or prevalent vertebral fracture (this drug reduces the incidence of fractures). -To increase bone mass in men with osteoporosis. -Treatment of glucocorticoid-induced osteoporosis in men and women who are either initiating or continuing systemic glucocorticoids in a daily dosage equivalent to 7.5 mg or greater of prednisone and are expected to remain on glucocorticoids for at least 12 months.
Usual Adult Dose for Prevention of Osteoporosis:
5 mg IV infusion over no less than 15 minutes, every 2 years Uses: -Prevention of osteoporosis in postmenopausal women. -Prevention of glucocorticoid-induced osteoporosis in men and women who are either initiating or continuing systemic glucocorticoids in a daily dosage equivalent to 7.5 mg or greater of prednisone and are expected to remain on glucocorticoids for at least 12 months.
Warnings
Zoledronic acid may harm an unborn baby. Do not use Reclast if you are pregnant. Use effective birth control, and ask your doctor how long to prevent pregnancy after you stop this medicine.
Reclast can cause serious kidney problems, especially if you are dehydrated, if you take diuretic medicine, or if you already have kidney disease. Call your doctor if you urinate less than usual, if you have swelling in your feet or ankles, or if you feel tired or short of breath.
Also call your doctor if you have muscle spasms, numbness or tingling (in hands and feet or around the mouth), new or unusual hip pain, or severe pain in your joints, bones, or muscles.
Your doctor may recommend you have a dental exam for preventive tooth and gum care before you start your treatment with zoledronic acid. This is especially important if you have cancer, if you are undergoing chemotherapy or using steroids, or if you have poor dental health.
Some people using medicines similar to Reclast have developed bone loss in the jaw, also called osteonecrosis of the jaw. Symptoms of this condition may include jaw pain, swelling, numbness, loose teeth, gum infection, or slow healing after injury or surgery involving the gums. You may be more likely to develop osteonecrosis of the jaw if you have cancer or have been treated with chemotherapy, radiation, or steroids. Other conditions associated with osteonecrosis of the jaw include blood clotting disorders, anemia (low red blood cells), and pre-existing dental problems.
What other drugs will affect Reclast
Zoledronic acid can harm your kidneys, especially if you also use certain medicines for infections, cancer, osteoporosis, organ transplant rejection, bowel disorders, high blood pressure, or pain or arthritis (including Advil, Motrin, and Aleve).
Other drugs may interact with zoledronic acid, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
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