Relyvrio

Generic name: Sodium Phenylbutyrate And Taurursodiol
Dosage form: powder for oral suspension
Drug class: Miscellaneous central nervous system agents

Usage of Relyvrio

Relyvrio is a prescription medicine used to treat adults with amyotrophic lateral sclerosis (ALS), commonly referred to as Lou Gehrig’s disease.

ALS is a neurodegenerative disease caused by motor neuron death in the brain and spinal cord.

The two ingredients contained in Relyvrio work together to reduce motor neuron cell death and inflammation, and slow down disease progression.

Relyvrio side effects

Relyvrio may cause serious side effects, including:

  • Changes in bile acid levels. Relyvrio may increase bile acid levels and cause worsening diarrhea if you already have problems with your liver, bile ducts, or pancreas. Your healthcare provider should monitor you for these side effects. Some disorders of the pancreas, bile ducts, or intestines may also make it harder to absorb Relyvrio.
  • Salt (sodium) retention. Relyvrio contains a high amount of salt. For people who are sensitive to salt intake, such as people with heart failure, high blood pressure, or kidney problems, limit the amount of salt you eat and drink.
  • Talk to your healthcare provider about the total amount of daily salt that is right for you. Your healthcare provider will monitor you for signs and symptoms of salt retention during your treatment.

    The most common side effects include:

  • diarrhea
  • abdominal pain
  • nausea
  • upper respiratory tract infection.
  • Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Relyvrio

    Before you start treatment, tell your healthcare provider about all of your medical conditions, including if you:

  • have pancreas, liver, or intestinal problems.
  • have heart failure, including congestive heart failure.
  • have high blood pressure.
  • have kidney problems.
  • are pregnant or plan to become pregnant. It is not known if Relyvrio will harm your unborn baby.
  • are breastfeeding or plan to breastfeed. It is not known if Relyvrio passes into your breast milk. You and your healthcare provider should decide the best way to feed your baby.
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    How to use Relyvrio

    Usual Adult Dose for Amyotrophic Lateral Sclerosis

    - The recommended dosage is 1 packet (3 g sodium phenylbutyrate and 1 g taurursodiol) daily for the first 3 weeks, and then 1 packet twice daily thereafter.

    - Comment: can be administered orally or via feeding tube.

    - Use: treatment of amyotrophic lateral sclerosis (ALS) in adults.

    What other drugs will affect Relyvrio

    Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements, and any taurursodiol products, such as tauroursodeoxycholic acid (TUDCA).

    Relyvrio may affect the way other medicines work, and other medicines may affect how Relyvrio works.

    Especially tell your doctor if you take:

  • cholestyramine, colestipol, or colesevelam;
  • cyclosporine;
  • aluminum-based antacids;
  • probenecid;
  • vorinostat, romidepsin, panobinostat, or Belinostat.
  • There are many other drugs that may interact with Relyvrio. Check with your healthcare provider before you start treatment.

    Disclaimer

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