Remdesivir

Generic name: Remdesivir
Brand names: Veklury
Drug class: Purine nucleosides

Usage of Remdesivir

Remdesivir is used to treat adults and children at least 28 days and older who weigh at least 7 pounds (3 kilograms) with positive results for COVID-19 who are:

in a hospital; or

not in a hospital and have mild-to-moderate COVID-19, and are at high risk for progression to severe COVID-19, including hospitalization or death.

Remdesivir may also be used for purposes not listed in this medication guide.

Remdesivir side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur during or after the injection. Tell your caregiver right away if you have:

severe headache, pounding in your neck or ears;

fast, slow, or pounding heartbeats;

wheezing, trouble breathing;

swelling in your face;

nausea;

fever, chills, or shivering;

itching, sweating; or

a light-headed feeling, like you might pass out;

Common side effects of remdesivir may include:

nausea; or

abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Remdesivir

You should not be treated with remdesivir if you are allergic to it.

Tell your doctor if you have ever had:

liver disease; or

kidney disease.

Tell your doctor if you are pregnant or plan to become pregnant, or if you are breastfeeding.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of remdesivir on the baby.

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How to use Remdesivir

Usual Adult Dose for COVID-19:

Loading dose (Day 1): 200 mg IV as a single doseMaintenance dose (from Day 2): 100 mg IV once a dayDuration of Therapy:-Hospitalized patients requiring invasive mechanical ventilation and/or extracorporeal membrane oxygenation (ECMO): 10 days total-Hospitalized patients not requiring invasive mechanical ventilation and/or ECMO: 5 days; may extend up to 5 additional days (for a total of up to 10 days) if no clinical improvement shown-Nonhospitalized patients: 3 days totalUse: For the treatment of coronavirus disease 2019 (COVID-19) in patients who are:-Hospitalized, or-Not hospitalized, have mild to moderate COVID-19, and are at high risk for progression to severe COVID-19, including hospitalization or death

Usual Pediatric Dose for COVID-19:

28 Days of Age and Older:Weight 3 to less than 40 kg:-Loading dose (Day 1): 5 mg/kg IV as a single dose-Maintenance dose (from Day 2): 2.5 mg/kg IV once a dayWeight at least 40 kg:-Loading dose (Day 1): 200 mg IV as a single dose-Maintenance dose (from Day 2): 100 mg IV once a dayDuration of Therapy:-Hospitalized patients requiring invasive mechanical ventilation and/or ECMO: 10 days total-Hospitalized patients not requiring invasive mechanical ventilation and/or ECMO: 5 days; may extend up to 5 additional days (for a total of up to 10 days) if no clinical improvement shown-Nonhospitalized patients: 3 days totalComments:-The lyophilized powder formulation is the only approved dosage form for pediatric patients weighing 3 to less than 40 kg.Use: For the treatment of COVID-19 in patients who are:-Hospitalized, or-Not hospitalized, have mild to moderate COVID-19, and are at high risk for progression to severe COVID-19, including hospitalization or death

Warnings

Remdesivir is for use only in people with COVID-19. You must remain under the care of a doctor while receiving remdesivir.

What other drugs will affect Remdesivir

Tell your doctor if you also take chloroquine or hydroxychloroquine. Either of these other medicines could make remdesivir less effective.

Other drugs may affect remdesivir, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

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