Repaglinide

Generic name: Repaglinide (oral)
Brand names: Prandin
Dosage form: oral tablet (0.5 mg; 1 mg; 2 mg)
Drug class: Meglitinides

Usage of Repaglinide

Repaglinide is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. repaglinide is not for treating type 1 diabetes.

Repaglinide may also be used for purposes not listed in this medication guide.

Repaglinide side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Repaglinide may cause serious side effects. Call your doctor at once if you have:

pale or yellowed skin, dark colored urine, fever, confusion or weakness; or

pancreatitis--severe pain in your upper stomach spreading to your back, nausea and vomiting.

Common side effects of repaglinide may include:

low blood sugar;

nausea, diarrhea;

headache, back pain;

joint pain; or

cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Repaglinide

You should not use repaglinide if you are allergic to it, or if you have:

severe liver disease; or

diabetic ketoacidosis (call your doctor for treatment).

Many drugs can interact with repaglinide and some drugs should not be used at the same time. Your doctor may change your treatment plan if you also use:

clopidogrel;

cyclosporine;

gemfibrozil; or

NPH insulin (such as isophane insulin).

Tell your doctor if you have ever had:

liver disease; or

if you also take metformin or other diabetes medicines.

Follow your doctor's instructions about using repaglinide if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

You should not breastfeed while using repaglinide.

Repaglinide is not approved for use by anyone younger than 18 years old.

Relate drugs

How to use Repaglinide

Usual Adult Dose for Diabetes Type 2:

Individualize therapy: Dose preprandially 2, 3, or 4 times a day-For patients not previously treated with antidiabetic agents or whose glycosylated hemoglobin (HbA1c) is less than 8%:Initial dose: 0.5 mg orally with each meal -For patients previously treated with antidiabetic agents or whose HbA1c is 8% or higher:Initial dose: 1 or 2 mg orally with each meal Dose Adjustments: Based upon blood glucose response, double the preprandial dose up to a maximum meal time dose of 4 mg until satisfactory glycemic response is achieved; allow at least 1 week to assess response after each dose adjustment. Recommended Dose Range: 0.5 to 4 mg orally with each mealMaximum Daily Dose: 16 mg per day Comments:-Fasting blood glucose concentrations are generally used to adjust doses, however, postprandial glucose levels may be used in patients whose pre-meal blood glucose levels are satisfactory but whose overall glycemic control (HbA1c) is inadequate. -When hypoglycemia occurs in patients taking this drug in combination with a thiazolidinedione or metformin, the dose of this drug should be reduced. Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Warnings

You should not use repaglinide if you have type 1 diabetes, severe liver disease, or diabetic ketoacidosis.

You should not use repaglinide together with gemfibrozil or NPH insulin (such as isophane insulin).

What other drugs will affect Repaglinide

Many other medicines that can increase or decrease the effects of repaglinide on lowering your blood sugar. Some drugs can also cause you to have fewer symptoms of hypoglycemia, making it harder to tell when your blood sugar is low. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

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