Rezzayo

Generic name: Rezafungin
Dosage form: powder for injection
Drug class: Echinocandins

Usage of Rezzayo

Rezzayo is a prescription medicine used to treat serious Candida fungal infections called candidemia and invasive candidiasis.

Rezzayo contains rezafungin, which belongs to the class of drugs called echinocandin antifungals.

Rezafungin works as an antifungal by inhibiting the formation of (1-3)-β-d-glucan (BDG), which an essential component of the cell wall of many fungi, including Candida.

Rezzayo side effects

Rezzayo may cause serious side effects including:

hypersensitivity reactions. Get emergency help if you have signs of an allergic reaction (hives, difficulty breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

infusion-related reactions. Tell your healthcare provider at once if you have symptoms of an infusion-related reaction (flushing, sensation of warmth, urticaria, nausea, or chest tightness). The infusion should be slowed or paused if these reactions occur.

photosensitivity reactions. Tell your healthcare provider if you develop a skin rash. You should use protection from sun exposure and other sources of UV radiation during treatment.

abnormalities in liver tests. Your healthcare provider will monitor you if you develop abnormal liver tests and will weigh up the risks versus benefits of continuing treatment.

Common side effects include:

hypokalemia (low blood potassium levels);

pyrexia (fever);

diarrhea;

anemia (low levels of red blood cells);

nausea;

vomiting;

hypomagnesemia (low levels of magnesium in the blood);

abdominal pain;

constipation; and

hypophosphatemia (low levels of phosphate in the blood).

Before taking Rezzayo

Before you start treatment, tell your healthcare provider about all of your medical conditions, including if you:

have a known hypersensitivity to rezafungin or other echinocandins.

Pregnancy

Tell your healthcare provider if you are pregnant or plan to become pregnant. It is not known if Rezzayo can harm your baby.

Breastfeeding

Tell your healthcare provider if you are breastfeeding or plan to breastfeed. It may not be safe to breastfeed while using Rezzayo. Talk to your healthcare provider about the best way to feed your baby during treatment.

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How to use Rezzayo

Usual Adult Dose for Candidemia and Invasive Candidiasis:

400 mg loading dose, followed by a 200 mg dose once weekly thereafter.

Comments: - Administer by intravenous (IV) infusion. Safety has not been established beyond 4 weekly doses.

Use: - treatment of patients 18 years of age or older who have limited or no alternative options for the treatment of candidemia and invasive candidiasis. Approval of this indication is based on limited clinical safety and efficacy data.

Warnings

Rezzayo may cause serious hypersensitivity reactions. You should not use this medicine if you have a known hypersensitivity to rezafungin or other echinocandins.

Rezzayo may cause infusion-related reactions, including flushing, sensation of warmth, urticaria, nausea, or chest tightness. If these reactions occur, your healthcare provider will slow or pause the infusion.

Rezzayo may cause photosensitivity reactions. You should use protection from sun exposure and other sources of UV radiation during treatment.

Rezzayo may cause abnormalities in liver tests. Your healthcare provider will monitor you if you develop abnormal liver tests and evaluate the risk versus benefit of continuing treatment.

What other drugs will affect Rezzayo

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

Disclaimer

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