Rifaximin

Generic name: Rifaximin
Brand names: Xifaxan
Dosage form: oral tablet (200 mg; 550 mg)
Drug class: Miscellaneous antibiotics

Usage of Rifaximin

Rifaximin is used to treat travelers' diarrhea caused by Escherichia coli (E. coli) in adults and children who are at least 12 years old. Most people get this infection by eating food or drinking fluids that have been contaminated with the E. coli bacteria.

Rifaximin is also used to treat irritable bowel syndrome (IBS) in adults whose main symptom is diarrhea.

Rifaximin is also used to lower the risk of a decline in brain function in adults with liver failure. Brain function can be affected when the liver stops working and cannot remove toxic substances from the body.

Rifaximin may also be used for purposes not listed in this medication guide.

Rifaximin side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Rifaximin may cause serious side effects. Call your doctor at once if you have:

severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);

fever; or

fluid build-up around the stomach--rapid weight gain, stomach pain and bloating, trouble breathing while lying down.

Common side effects of rifaximin may include:

swelling in your hands or feet;

nausea;

headache, dizziness;

tiredness; or

abnormal liver function tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Rifaximin

You should not take rifaximin if you are allergic to rifaximin, rifabutin, rifampin, or rifapentine.

Tell your doctor if you have ever had:

liver disease;

diarrhea with a fever; or

watery or bloody diarrhea.

Tell your doctor if you are pregnant or breastfeeding.

Rifaximin should not be given to a child younger than 12 years old.

Relate drugs

How to use Rifaximin

Usual Adult Dose for Traveler's Diarrhea:

200 mg orally 3 times a day for 3 daysComments:-This drug should not be used in patients with diarrhea complicated by fever or blood in the stool or diarrhea caused by pathogens other than Escherichia coli.Use: For the treatment of travelers' diarrhea due to noninvasive strains of E coli

Usual Adult Dose for Hepatic Encephalopathy:

550 mg orally twice a dayComments:-In trials, lactulose was used concomitantly in 91% of patients; differences in treatment effect of patients not using concomitant lactulose could not be assessed.Use: For reduction in risk of overt hepatic encephalopathy recurrence

Usual Adult Dose for Irritable Bowel Syndrome:

550 mg orally 3 times a day for 14 daysComments:-If symptoms recur, patients can be retreated up to 2 times with the same dosage regimen.Use: For the treatment of irritable bowel syndrome with diarrhea

Usual Pediatric Dose for Traveler's Diarrhea:

12 years or older: 200 mg orally 3 times a day for 3 daysComments:-This drug should not be used in patients with diarrhea complicated by fever or blood in the stool or diarrhea caused by pathogens other than E coli.Use: For the treatment of travelers' diarrhea due to noninvasive strains of E coli

Warnings

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What other drugs will affect Rifaximin

Tell your doctor about all your other medicines, especially:

cyclosporine;

ketoconazole;

warfarin (Coumadin, Jantoven);

an antibiotic--clarithromycin, erythromycin;

antiviral medicine--ritonavir, saquinavir; or

heart or blood pressure medicine--amiodarone, quinidine, verapamil.

This list is not complete. Other drugs may affect rifaximin, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

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