Riociguat
Generic name: Riociguat
Brand names: Adempas
Dosage form: oral tablet (0.5 mg; 1 mg; 1.5 mg; 2 mg; 2.5 mg)
Drug class:
Vasodilators
Usage of Riociguat
Riociguat is used to treat chronic thromboembolic pulmonary hypertension (CTEPH) in people who cannot be treated with surgery, or in people who have undergone surgery but still have symptoms. Riociguat can treat certain symptoms of CTEPH and can improve your ability to exercise.
Riociguat is also used to treat pulmonary arterial hypertension (PAH). Riociguat can improve your ability to exercise and help prevent PAH from getting worse.
Riociguat is available to women only under a special program. You must be registered in the program and understand the risks and benefits of riociguat.
Riociguat may also be used for purposes not listed in this medication guide.
Riociguat side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Riociguat may cause serious side effects. Stop using riociguat and call your doctor at once if you have:
Common side effects of riociguat may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Riociguat
You should not use riociguat if you are allergic to it, or if:
Some medicines can cause unwanted or dangerous effects when used with riociguat. Your doctor may change your treatment plan if you also use:
Do not take riociguat within 24 hours before or after taking sildenafil (Revatio, Viagra), or within 24 hours before or 48 hours after taking tadalafil (Adcirca, Cialis).
Tell your doctor if you have ever had:
Do not use riociguat if you are pregnant. It could harm the unborn baby or cause birth defects. Use effective birth control to prevent pregnancy while you are using riociguat and for at least 1 month after your treatment ends. Tell your doctor right away if you miss a menstrual period or think you may have become pregnant during treatment.
You will need to have a negative pregnancy test before starting this treatment. You will also be re-tested every month during your treatment, and 1 month after you stop taking this medicine. Do not have unprotected sex.
While taking riociguat, girls and women who are able to get pregnant must use highly effective birth control, or two methods together.
Even if you are not planning a pregnancy, you are considered able to become pregnant if:
Riociguat comes with patient instructions about acceptable forms of birth control to use while taking this medicine. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.
Even if your sexual partner has had a vasectomy, you must still use a second method of birth control--either a barrier method or a hormonal form (birth control pills, injections, skin patch, or vaginal ring).
If you are the parent or caregiver of a female child taking this medication, talk to the child's doctor once you notice any signs of puberty (breast development or pubic hair), even if menstrual periods have not yet begun.
You should not breast-feed while using this medicine.
Relate drugs
- Adempas
- Apresoline
- Apresoline (Hydralazine Injection)
- Apresoline (Hydralazine Oral)
- Hydralazine
- Hydralazine (Injection)
- Hydralazine (Oral)
- Loniten
- Minoxidil
- Minoxidil (Oral)
- Natrecor
- Nesiritide
- Novaplus HydrALAZINE Hydrochloride
- Riociguat
- Vericiguat
- Verquvo
How to use Riociguat
Usual Adult Dose for Pulmonary Hypertension:
Initial dose: 1 mg orally 3 times a dayMaximum dose: 2.5 mg orally 3 times a dayComments: -For patients who cannot tolerate the hypotensive effect, consider a starting dose of 0.5 mg orally 3 times a day. If systolic blood pressure remains greater than 95 mmHg and the patient has no signs of hypotension, the dose may be titrated up by 0.5 mg orally 3 times a day.-Dose increases should be no more frequent than every 2 weeks.Uses:-Persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH) (WHO group 4) after surgical treatment or inoperable CTEPH to improve exercise capacity and WHO functional class.-As monotherapy or in combination with endothelin receptor antagonists or prostanoids to treat pulmonary arterial hypertension (PAH) (WHO group 1) to improve exercise capacity, improve WHO functional class and to delay clinical worsening.
Warnings
Riociguat can cause birth defects. Do not use if you are pregnant. You must use highly effective birth control while taking riociguat and for at least 1 month after your last dose. Do not have unprotected sex.
What other drugs will affect Riociguat
Other drugs may affect riociguat, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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