Rukobia

Generic name: Fostemsavir (extended-release Tablets)
Drug class: Miscellaneous antivirals

Usage of Rukobia

Rukobia is a prescription medicine that is used with other antiretroviral medicines to treat Human Immunodeficiency Virus (HIV-1) infection in adults who:

  • have received several anti-HIV-1 regimens in the past, and
  • have HIV-1 virus that is resistant to many antiretroviral medicines, and
  • are failing their current antiretroviral therapy. You could be failing therapy because it is not working or no longer works, you are not able to tolerate the side effects, or there are other safety reasons why you cannot take it.

    • HIV-1 is the virus that causes Acquired Immune Deficiency Syndrome (AIDS). It is not known if this medicine is safe and effective in children.

    Rukobia side effects

    Rukobia can cause serious side effects including:

  • Changes in your immune system (Immune Reconstitution Syndrome) can happen when you start taking HIV-1 medicines. Your immune system may get stronger and begin to fight infections that have been hidden in your body for a long time. Tell your healthcare provider right away if you start having new symptoms after you start taking Rukobia.
  • Heart rhythm problems (QTc prolongation). Rukobia may cause a heart rhythm problem called QTc prolongation. QTc prolongation causes an irregular heartbeat. If you are elderly, you may be at a greater risk for developing this heart problem with Rukobia. Tell your healthcare provider right away if you feel dizzy, lightheaded, feel changes in your heartbeat, or you faint (lose consciousness).
  • Changes in liver function blood tests results. People with HIV-1 who take Rukobia and who also have hepatitis B or C virus infections, may be more likely to develop new or worsening changes in certain liver function blood tests during treatment.
  • If you stop your anti-hepatitis B treatment, this could mean that your hepatitis B may become active again (reactivated). Your healthcare provider may do blood tests to check your liver during treatment with Rukobia especially if you have hepatitis B virus infection.
  • Take any anti-hepatitis B or anti-hepatitis C medicines as prescribed by your healthcare provider during treatment with Rukobia.

    • The most common side effect is nausea.

    These are not all of the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Rukobia

    You should not take Rukobia if you:

  • are allergic to fostemsavir or any of the ingredients. See the end of this page for a complete list of ingredients.
  • take certain medicines, including:
  • enzalutamide
  • Carbamazepine
  • phenytoin
  • rifampin
  • mitotane
  • St. John’s wort (Hypericum perforatum)

    • Relate drugs

    How to use Rukobia

  • Take Rukobia exactly as your healthcare provider tells you to take it.
  • Take the Rukobia tablets whole. Do not chew, crush, or split the tablets before swallowing.
  • Take the tablets with or without food.
  • Rukobia tablets may have a slight odor (like vinegar). This is normal.
  • Do not miss a dose. If you miss a dose, take it as soon as you remember. Do not take 2 doses at the same time or take more than your healthcare provider tells you to take.
  • Do not run out of Rukobia. The virus in your blood may increase and the virus may become harder to treat. When your supply starts to run low, get more from your healthcare provider or pharmacy.
  • If you take too much Rukobia, call your healthcare provider or go to the nearest hospital emergency room right away.

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