Ruxolitinib topical

Generic name: Ruxolitinib Topical
Brand names: Opzelura
Dosage form: topical cream (1.5%)
Drug class: Topical antineoplastics

Usage of Ruxolitinib topical

Ruxolitinib topical (for the skin) is used as a short-term treatment of mild to moderate eczema (atopic dermatitis) in people 12 years and older.

ruxolitinib topical should only be used when other drugs are not recommended or have not worked.

Ruxolitinib topical may also be used for purposes not listed in this medication guide.

Ruxolitinib topical side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Ruxolitinib topical may cause serious side effects. Call your doctor at once if you have:

changes in the size, shape, or color of a mole or skin lesion;

signs of a stroke--sudden numbness or weakness, severe headache, slurred speech, problems with vision or balance;

signs of a blood clot in the lung--chest pain, sudden cough or shortness of breath, dizziness, coughing up blood;

signs of a blood clot deep in the body--pain, swelling, or warmth in one leg;

signs of infection--fever, chills, sore throat, body aches, unusual tiredness, loss of appetite, bruising or bleeding;

low blood cell counts--fever, chills, tiredness, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath; or

signs of tuberculosis: fever, cough, night sweats, loss of appetite, weight loss, and feeling very tired.

Common side effects of ruxolitinib topical may include:

pain or swelling in your nose or throat;

diarrhea;

bronchitis;

high eosinophil (a type of white blood cell) count;

hives;

inflamed hair pores;

swelling of the tonsils;

runny nose; or

ear infection--fever, ear pain or full feeling, trouble hearing, drainage from the ear, fussiness in a child.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Ruxolitinib topical

Tell your doctor if you have ever had tuberculosis or if anyone in your household has tuberculosis. Also tell your doctor if you have recently traveled. Tuberculosis and some fungal infections are more common in certain parts of the world, and you may have been exposed during travel.

Tell your doctor if you have ever had:

an infection;

shingles;

hepatitis B or C;

skin cancer;

low white or red blood cell counts;

high cholesterol or triglycerides (types of fat in the blood); or

if you've ever smoked.

Using ruxolitinib may increase your risk of developing skin cancer. Talk to your doctor about this risk and what skin symptoms to watch for.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of ruxolitinib topical on the baby.

It is not known whether ruxolitinib will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

You should not breastfeed while you are using ruxolitinib, and for at least 4 weeks after your last dose.

Relate drugs

Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

What other drugs will affect Ruxolitinib topical

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Tell your doctor about all your other medicines, especially:

"biologic" medications to treat atopic dermatitis;

other JAK inhibitors such as Baricitinib, tofacitinib, or upadacitinib; or

strong immunosuppressants such as azathioprine or cyclosporine.

This list is not complete. Other drugs may affect ruxolitinib topical, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.