Ryzodeg 70/30

Generic name: Insulin Aspart And Insulin Degludec
Brand names: Ryzodeg 70/30 FlexTouch
Drug class: Insulin

Usage of Ryzodeg 70/30

Ryzodeg contains a combination of insulin aspart and insulin degludec. Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Insulin aspart is a fast-acting insulin. Insulin degludec is a long-acting insulin. This combination insulin starts to work within 10 to 20 minutes after injection, peaks in about 1 hour, and keeps working for 24 hours or longer.

Ryzodeg is used to improve blood sugar control in adults with diabetes mellitus.

Ryzodeg may be used for type 1 or type 2 diabetes.

Ryzodeg 70/30 side effects

Get emergency medical help if you have signs of an allergic reaction to Ryzodeg: hives, itching, skin rash; wheezing, tiredness, trouble breathing; feeling like you might pass out; nausea, diarrhea; swelling of your face, lips, tongue, or throat.

Call your doctor if you have:

fluid retention - weight gain, swelling in your hands or feet, feeling short of breath; or

low potassium - leg cramps, constipation, irregular heartbeats, fluttering in your chest, extreme thirst, increased urination, numbness or tingling, muscle weakness or limp feeling.

Common Ryzodeg side effects may include:

low blood sugar;

itching, mild skin rash; or

thickening or hollowing of the skin where you injected the medicine.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Ryzodeg 70/30

You should not use Ryzodeg if you are allergic to insulin aspart or insulin degludec, or if you are having an episode of hypoglycemia (low blood sugar).

Ryzodeg is not approved for use by anyone younger than 18 years old.

To make sure Ryzodeg is safe for you, tell your doctor if you have:

liver or kidney disease;

low levels of potassium in your blood (hypokalemia); or

diabetic ketoacidosis (call your doctor for treatment).

Tell your doctor if you also take pioglitazone or rosiglitazone (sometimes contained in combinations with glimepiride or metformin). Taking certain oral diabetes medicines while you are using Ryzodeg may increase your risk of serious heart problems.

Follow your doctor's instructions about using Ryzodeg if you are pregnant. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester of pregnancy.

Ask your doctor about using Ryzodeg if you are breast-feeding a baby. Your dose needs may be different while you are nursing.

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How to use Ryzodeg 70/30

Usual Adult Dose of Ryzodeg for Diabetes Type 1:

Dose should be individualized based on clinical response; Generally used in regimens with additional short or rapid acting insulin at meals not covered by this insulin mix. Insulin-naive patients: Initial dose: One-third to one-half the total daily insulin requirement suBCutaneously once a day. -The initial total daily insulin requirement in insulin naive patients is generally 0.2 to 0.4 units of insulin per kilogram of body weight. Switching from Once or Twice Daily Premix Insulin: -Initiate at the same unit dose and injection schedule as the current premix or self-mix insulin. -Short or rapid-acting insulin should be used for meals not covered by this insulin mix. Switching from Once or Twice Daily Basal Insulin: -Initiate at the same unit dose as the basal insulin once a day with the main meal of the day. -Short or rapid-acting insulin should be used for meals not covered by this insulin mix. Comments: -Adjust dosage according to metabolic needs, blood glucose measurements, and glycemic goals. -Dose increases should occur no sooner than every 3 to 4 days; dose adjustment should be made based on morning fasting blood glucose measurement (before breakfast). -When changing treatment regimens, the dose and frequency of short or rapid-acting insulin may need to be adjusted. -To minimize hypoglycemia, closely monitor blood glucose, especially with changing regimens. Use: To improve glycemic control in patients with diabetes mellitus.

Usual Adult Dose of Ryzodeg for Diabetes Type 2:

Initial dose: 10 units subcutaneously once a day Switching from Once or Twice Daily Premix Insulin: -Initiate subcutaneously at the same unit dose and injection schedule as the current premix or self-mix insulin. -Short or rapid-acting insulin may be used for meals not covered by this insulin mix. Switching from Once or Twice Daily Basal Insulin: -Initiate at the same unit dose as the basal insulin once a day with the main meal of the day. -For patients switching from once-daily basal insulin to this insulin mix, monitor blood glucose after starting therapy due to the rapid-acting insulin component. -Short or rapid-acting insulin may be used for meals not covered by this insulin mix. Comments: -Adjust dosage according to metabolic needs, blood glucose measurements, and glycemic goals; dose increases should occur no sooner than every 3 to 4 days. -When changing treatment regimens, the dose and frequency of short or rapid-acting insulin or other anti-diabetic medications may need to be adjusted. -To minimize hypoglycemia, closely monitor blood glucose, especially with changing regimens. Use: To improve glycemic control in patients with diabetes mellitus.

Warnings

You should not use Ryzodeg if you are having an episode of hypoglycemia (low blood sugar).

Never share a Ryzodeg injection pen with another person, even if the needle has been changed.

What other drugs will affect Ryzodeg 70/30

Many other medicines can affect your blood sugar, and some medicines can increase or decrease the effects of insulin. Some drugs can also cause you to have fewer symptoms of hypoglycemia, making it harder to tell when your blood sugar is low. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. This includes prescription and over-the-counter medicines, vitamins, and herbal products.

Disclaimer

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