Sacituzumab govitecan
Generic name: Sacituzumab Govitecan
Brand names: Trodelvy
Dosage form: intravenous powder for injection (hziy 180 mg)
Drug class:
Miscellaneous antineoplastics
Usage of Sacituzumab govitecan
Sacituzumab govitecan is used to treat breast cancer in adults who previously received endocrine therapy and at least two other cancer medications.
Sacituzumab govitecan is also used in adults to treat cancers of the bladder and urinary tract, after treatment with a platinum cancer medicine and an immunotherapy treatment.
Sacituzumab govitecan is used when the cancer has spread to other parts of the body (metastatic) or cannot be removed with surgery.
Sacituzumab govitecan may also be used for purposes not listed in this medication guide.
Sacituzumab govitecan side effects
sacituzumab govitecan can cause severe or life-threatening allergic Reactions.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may occur during the injection or within 24 hours afterward. Tell your medical caregivers if you feel dizzy, light-headed, itchy, sweaty, or have a fever, chills, trouble breathing, or swelling in your face or throat.
You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as:
Sacituzumab govitecan can cause severe diarrhea. Tell your doctor right away if you have:
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects of sacituzumab govitecan may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Sacituzumab govitecan
You should not be treated with sacituzumab govitecan if you have ever HAD a severe allergic reaction to it.
Tell your doctor if you have ever had:
Sacituzumab govitecan can harm an unborn baby if the mother or the father is using sacituzumab govitecan.
Do not breastfeed while using this medicine, and for at least 1 month after your last dose.
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How to use Sacituzumab govitecan
Usual Adult Dose for Breast Cancer:
10 mg/kg IV once a week on Days 1 and 8 of 21-Day treatment cyclesMaximum dose: 10 mg/kg per doseDuration of therapy: Until disease progression or uNACceptable toxicityUse: For the treatment of patients with unresectable locally advanced or metastatic triple-negative breast cancer (mTNBC) who have received 2 or more prior systemic therapies, at least 1 of them for metastatic disease
Usual Adult Dose for Urothelial Carcinoma:
10 mg/kg IV once a week on Days 1 and 8 of 21-day treatment cyclesMaximum dose: 10 mg/kg per doseDuration of therapy: Until disease progression or unacceptable toxicityComments:-This indication is approved under accelerated approval based on tumor response rate and duration of response; continued approval may be contingent on verification and description of clinical benefit in a cOnfirmatory trial.Use: For the treatment of patients with locally advanced or metastatic urothelial cancer (mUC) who have previously received a platinum-containing chemotherapy and either programmed death receptor-1 (PD-1) or programmed death-ligand 1 (PD-L1) inhibitor
Warnings
You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, burning when you urinate, a cough, or trouble breathing.
Sacituzumab govitecan commonly causes diarrhea. Severe diarrhea can lead to dehydration, which may require medical treatment.
Tell your doctor right away the first time you have diarrhea while receiving this medicine, or if you have black or bloody stools, if you feel light-headed, if you can't keep liquids down because of vomiting, or if you can't get your diarrhea to stop within 24 hours.
What other drugs will affect Sacituzumab govitecan
Other drugs may affect sacituzumab govitecan, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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