Safinamide
Generic name: Safinamide
Brand names: Xadago
Dosage form: oral tablet (100 mg; 50 mg)
Drug class:
Dopaminergic antiparkinsonism agents
Usage of Safinamide
Safinamide is monoamine oxidase inhibitor type B (MAO-B). safinamide works by allowing a chemical called doPamine (DOE pa meen) to work for longer periods of time in the brain. Low levels of dopamine in the brain are associated with Parkinson's disease.
Safinamide is given with Levodopa and Carbidopa to treat "wearing-off" episodes (muscle stiffness, loss of muscle control) in people with Parkinson's disease.
Safinamide may also be used for purposes not listed in this medication guide.
Safinamide side effects
Get emergency medical help if you have signs of an allergic Reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Safinamide may cause serious side effects. Call your doctor at once if you have:
You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs.
Common side effects of safinamide may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Safinamide
You should not use safinamide if you are allergic to it, or if you have:
Some medicines can cause unwanted or dangerous effects (including death) when used with safinamide. You should not use any of the following medicines within 14 days before or 14 days after you take safinamide:
To make sure safinamide is safe for you, tell your doctor if you have ever had:
It is not known whether safinamide will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether safinamide passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Relate drugs
- Apokyn
- Apomorphine
- Apomorphine (Subcutaneous)
- Apomorphine (Sublingual)
- Azilect
- Comtan
- Carbidopa
- Carbidopa and levodopa
- Carbidopa and levodopa (Oral)
- Carbidopa and levodopa enteral
- Carbidopa, entacapone, and levodopa
- Dhivy
- Duopa
- Entacapone
- Gocovri
- Inbrija
- Kynmobi
- Levodopa
- Levodopa (Oral)
- Lodosyn
- Mirapex
- Mirapex ER
- Neupro
- Ongentys
- Opicapone
- Osmolex ER
- Parcopa
- Pramipexole
- Rasagiline
- Requip
- Requip XL
- Ropinirole
- Rotigotine
- Rotigotine transdermal
- Rytary
- Safinamide
- Sinemet
- Sinemet 10-100
- Sinemet 25-100
- Sinemet 25-250
- Sinemet CR
- Stalevo 100
- Stalevo 125
- Stalevo 150
- Stalevo 200
- Stalevo 50
- Stalevo 75
- Tasmar
- Tolcapone
- Xadago
How to use Safinamide
Usual Adult Dose for Parkinson's Disease:
Initial dose: 50 mg orally once a dayMaintenance dose: After 2 weeks, may increase dose to 100 mg orally once a day based on individual need and tolerabilityMaximum dose: 100 mg per day Comment:-Higher doses have not been shown to provide additional benefit while they do increase the risk for adverse reactions. -This drug has only been shown effective in combination with levodopa/carbidopa. Use: As adjunctive treatment to levodopa/carbidopa in patients with PD experiencing "off" episodes.
Warnings
You should not use safinamide if you have severe liver disease.
TELL YOUR DOCTOR ABOUT ALL OTHER MEDICINES YOU USE. Some medicines can cause unwanted or dangerous effects (including death) when used within 14 days of when you take safinamide.
What other drugs will affect Safinamide
Tell your doctor about all your current medicines and any you start or stop using, especially:
This list is not complete. Other drugs may interact with safinamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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