Sarclisa

Generic name: Isatuximab-irfc
Dosage form: injection, for intravenous use
Drug class: CD38 monoclonal antibodies

Usage of Sarclisa

Sarclisa is a prescription medicine used in combination with:

  • the medicines pomalidomide and Dexamethasone, to treat adults who have received at least 2 prior therapies including Lenalidomide and a proteasome inhibitor to treat multiple myeloma.
  • the medicines Carfilzomib and dexamethasone, to treat adults with multiple myeloma who have already received 1 to 3 lines of treatment and they did not work or are no longer working.

    • It is not known if Sarclisa is safe and effective in children.

    Sarclisa side effects

  • Sarclisa may cause serious side effects including:
  • Infusion reactions. Infusion reactions are common and can sometimes be severe or life threatening.
  • Your healthcare provider will prescribe medicines before each infusion of Sarclisa to help decrease your risk for infusion reactions or to help make any infusion reaction less severe. You will be monitored for infusion reactions during each dose.
  • Your healthcare provider may slow down or stop your infusion, or completely stop treatment if you have an infusion reaction.

    • Get medical help right away if you develop any of the following symptoms of infusion reaction during or after an infusion of Sarclisa:

  • shortness of breath, wheezing or trouble breathing
  • swelling of the face, mouth, throat, or tongue
  • throat tightness
  • palpitations
  • dizziness, lightheadedness, or fainting
  • headache
  • cough
  • rash or itching
  • nausea
  • runny or stuffy nose
  • chills
  • Decreased white blood cell counts. Decreased white blood cell counts are common with Sarclisa and certain white blood cells can be severely decreased. You may have an increased risk of getting certain infections, such as upper and lower respiratory tract infections and urinary tract infections. Your healthcare provider will check your blood cell counts during treatment. Your healthcare provider may prescribe an antibiotic or antiviral medicine to help prevent infection, or a medicine to help increase your white blood cell counts during treatment. Tell your healthcare provider right away if you develop any fever or symptoms of infection during treatment.
  • Risk of new cancers. New cancers have happened in people during treatment with Sarclisa. Your healthcare provider will monitor you for new cancers during treatment.
  • Change in blood tests. Sarclisa can affect the results of blood tests to match your blood type. Your healthcare provider will do blood tests to match your blood type before you start treatment. Tell all of your healthcare providers that you are being treated with Sarclisa before receiving blood transfusions.
  • Heart failure. Heart failure can happen during treatment with Sarclisa in combination with carfilzomib and dexamethasone. Tell your healthcare provider right away if you develop any of the following symptoms:
  • trouble breathing
  • cough
  • swelling of your ankles, feet, and legs

    • The most common side effects of Sarclisa in combination with pomalidomide and dexamethasone include:

  • lung infection (pneumonia)
  • decreased red blood cell counts (anemia)
  • upper respiratory tract infection
  • decreased platelet counts  (thrombocytopenia)
  • diarrhea

    • The most common side effects of Sarclisa in combination with carfilzomib and dexamethasone include:

  • upper respiratory tract infection
  • tiredness and weakness
  • high blood pressure
  • diarrhea
  • trouble sleeping
  • bronchitis
  • cough
  • back pain
  • lung infection (pneumonia)
  • trouble breathing
  • decreased red blood cell counts (anemia)
  • decrease platelet count (thrombocytopenia) 

    • These are not all the possible side effects. For more information, ask your healthcare provider or pharmacist.

    Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Sarclisa

    You should not receive Sarclisa if you have a history of a severe allergic reaction to isatuximab-irfc or any of the ingredients. See the end of this page for complete list of ingredients.

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    How to use Sarclisa

  • Sarclisa will be given to you by your healthcare provider by intravenous (IV) infusion into your vein.
  • Sarclisa is given in treatment cycles of 28 days (4 weeks), together with the medicines pomalidomide and dexamethasone, or carfilzomib and dexamethasone.
  • In cycle 1, Sarclisa is usually given weekly.
  • Starting in cycle 2, Sarclisa is usually given every 2 weeks. Your healthcare provider will decide how long you should receive this medicine.
  • If you miss any appointments, call your healthcare provider as soon as possible to reschedule your appointment.
  • Your healthcare provider will give you medicines before each dose of Sarclisa, to help reduce the risk of infusion reactions (make them less frequent and severe).

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    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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