Satralizumab

Generic name: Satralizumab
Brand names: Enspryng
Dosage form: subcutaneous solution (120 mg/mL)
Drug class: Interleukin inhibitors

Usage of Satralizumab

Satralizumab is used to treat adults with neuromyelitis optica spectrum disorder (NMOSD). NMOSD is a rare, chronic autoimmune disease that causes inflammation in the central nervous system. This can lead to damage of the optic nerves, spinal cord, and/or brain.

Satralizumab is used only if your body produces antibodies to a protein called aquaporin-4 (AQP4). Your doctor will test you for this antibody.

Satralizumab may also be used for purposes not listed in this medication guide.

Satralizumab side effects

Stop using satralizumab and get emergency medical help if you have signs of an allergic reaction: hives; feeling light-headed; stomach pain, vomiting; difficult breathing; swelling of your face, lips, tongue, or throat.

You may get infections more easily, even serious or fatal infections. Call your doctor right away if you have signs of infection such as:

  • fever, chills, night sweats;
  • sore throat. ongoing cough, feeling very tired;
  • muscle pain;
  • diarrhea, stomach cramps;
  • loss of appetite, weight loss;
  • increased urination, burning when you urinate; or
  • skin sores, redness, swelling or tenderness.

    • Common side effects of satralizumab may include:

  • headache, joint pain;
  • nausea, stomach pain;
  • feeling tired;
  • pain in your arms, hands, legs, or feet;
  • rash; or
  • cold symptoms such as stuffy nose, runny nose, sneezing, sore throat.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Satralizumab

    You should not use satralizumab if you are allergic to it, or if you have an active infection such as:

  • hepatitis B; or
  • tuberculosis.

    • Tell your doctor if you have ever had tuberculosis, if anyone in your household has tuberculosis, or if you have recently traveled to an area where tuberculosis is common.

    Tell your doctor if you have ever had:

  • an active or chronic infection;
  • liver problems, hepatitis B (or if you are a carrier of hepatitis B); or
  • if you have recently received or are scheduled to receive a vaccine.

    • Make sure you are current on all vaccines before you begin treatment with satralizumab.

    You should not receive a "live" vaccine for at least 4 weeks before using satralizumab. Live vaccines include measles, mumps, rubElla (MMR), rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine.

    You should not receive a "non-live" (sometimes called inactivated) vaccine for at least 2 weeks before using satralizumab. Non-live vaccines include the flu (influenza) shot and injected vaccines for hepatitis A, polio, or rabies.

    Tell your doctor if you are pregnant or breastfeeding.

    If you use satralizumab while you are pregnant, make sure any doctor caring for your new baby knows that you used satralizumab during pregnancy. Being exposed to satralizumab in the womb could affect your baby's vaccination schedule.

    Relate drugs

    How to use Satralizumab

    Usual Adult Dose for Neuromyelitis Optica:

    120 mg suBCUTAneously at Weeks 0, 2, and 4, followed by 120 mg subcutaneously every 4 weeksUse: For the treatment of neuromyelitis optica spectrum disorder (NMOSD) in adult patients who are anti-aquaporin-4 (AQP4) antibody positive

    Warnings

    Satralizumab affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have signs of infection (fever, chills, cough, tiredness, muscle pain, diarrhea, stomach cramps, increased urination, burning when you urinate, skin sores or redness, swelling or tenderness).

    What other drugs will affect Satralizumab

    Other drugs may affect satralizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

    Disclaimer

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