Saxagliptin

Generic name: Saxagliptin
Brand names: Onglyza
Dosage form: oral tablet (2.5 mg; 5 mg)
Drug class: Dipeptidyl peptidase 4 inhibitors

Usage of Saxagliptin

Saxagliptin is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus. Saxagliptin is not for treating type 1 diabetes.

Saxagliptin is sometimes used in combination with other diabetes medications.

Saxagliptin may also be used for purposes not listed in this medication guide.

Saxagliptin side effects

Get emergency medical help if you have signs of an allergic reaction: hives, a purple or red skin rash that spreads and causes blistering and peeling; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking saxagliptin and call your doctor right away if you have symptoms of pancreatitis: severe pain in your upper stomach spreading to your back, nausea and vomiting, loss of appetite, or fast heartbeats.

Saxagliptin may cause serious side effects. Call your doctor at once if you have:

  • severe or ongoing pain in your joints;
  • pain or burning when you urinate; or
  • heart problems--shortness of breath (even while lying down), feeling weak or tired, rapid weight gain, swelling (especially in your feet, legs, or midsection.

    • Common side effects of saxagliptin may include:

  • painful urination;
  • headache;
  • runny or stuffy nose, sore throat, cough; or
  • swelling in your hands or feet.

    • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Saxagliptin

    You should not use this medicine if you have ever had a severe allergic reaction to saxagliptin, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment).

    Tell your doctor if you have ever had:

  • kidney disease (or if you are on dialysis);
  • heart disease;
  • pancreatitis;
  • gallstones;
  • high triglycerides (a type of fat in the blood); or
  • alcoholism.

    • Follow your doctor's instructions about using this medicine if you are pregnant or you become pregnant. Controlling diabetes is very important during pregnancy, and having high blood sugar may cause complications in both the mother and the baby.

    It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

    Saxagliptin is not approved for use by anyone younger than 18 years old.

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    How to use Saxagliptin

    Usual Adult Dose for Diabetes Type 2:

    2.5 or 5 mg orally once a day, regardless of mealsCoadministration with strong CYP450 3A4/5 inhibitors: 2.5 mg orally once a dayUse: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes in multiple clinical settings

    Warnings

    You should not use saxagliptin if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

    Saxagliptin is not for treating type 1 diabetes.

    What other drugs will affect Saxagliptin

    Other drugs may increase or decrease the effects of saxagliptin on lowering your blood sugar. Tell your doctor about all medications you use. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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