Seglentis

Generic name: Celecoxib And Tramadol Hydrochloride
Dosage form: tablets
Drug class: Narcotic analgesic combinations

Usage of Seglentis

Seglentis is:

  • A strong prescription pain medicine that contains the opioid (narcotic) tramadol and the Nonsteroidal Anti-inflammatory Drug (NSAID) Celecoxib.
  • Seglentis is used for the management of acute pain in adults, when other pain treatments such as non-opioid pain medicines do not treat your pain well enough or you cannot tolerate them.
  • An opioid pain medicine that can put you at risk for overdose and death. Even if you take your dose correctly as prescribed you are at risk for opioid addiction, abuse, and misuse that can lead to death.

    • Seglentis side effects

    The possible side effects of Seglentis:

  • constipation, nausea, sleepiness, vomiting, tiredness, headache, dizziness, abdominal pain. Call your healthcare provider if you have any of these symptoms and they are severe.
  • NSAIDs can cause serious side effects, including: new or worse high blood pressure, heart failure, liver problems including liver failure, kidney problems including kidney failure, low red blood cells (anemia), life-threatening skin reactions, lifethreatening allergic reactions. Other side effects of NSAIDs include: stomach pain, constipation, diarrhea, gas, heartburn, nausea, vomiting, and dizziness.

    • Get emergency medical help or call 911 right away if you have:

  • trouble breathing, shortness of breath, fast heartbeat, chest pain, swelling of your face, tongue, or throat, extreme drowsiness, light-headedness when changing positions, feeling faint, agitation, high body temperature, trouble walking, stiff muscles, or mental changes such as confusion.

    • Stop taking Seglentis and call your healthcare provider right away if you get any of the following symptoms:

  • nausea, more tired or weaker than usual, diarrhea, itching, your skin or eyes look yellow, indigestion or stomach pain, flulike symptoms, vomit blood, there is blood in your bowel movement or it is black and sticky like tar, unusual weight gain, skin rash or blisters with fever, swelling of the arms, legs, hands and feet.

    • Seglentis may cause fertility problems in males and females, which may affect the ability to have children. Talk to your healthcare provider if you have concerns about fertility.

    These are not all the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. For more information go to dailymed.nlm.nih.gov.

    Other information about NSAIDs:

  • Aspirin is an NSAID but it does not increase the chance of a heart attack. Aspirin can cause bleeding in the brain, stomach, and intestines. Aspirin can also cause ulcers in the stomach and intestines.
  • Some NSAIDs are sold in lower doses without a prescription (over the counter). Talk to your healthcare provider before using over-the-counter NSAIDs for more than 10 days.

    • Before taking Seglentis

    Do not take Seglentis if you have:

  • Severe asthma, trouble breathing, or other lung problems.
  • A bowel blockage or narrowing of the stomach or intestines.
  • An allergy to tramadol, opioids, celecoxib, sulfonamides, or any of the inactive ingredients.
  • Had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAIDs.
  • Taken a Monoamine Oxidase Inhibitor, MAOI (medicine used for depression) within the last 14 days or are currently taking one.

    • Do not take Seglentis right before or after heart bypass surgery.

    Relate drugs

    How to use Seglentis

    - Two Seglentis (celecoxib 56 mg and tramadol hydrochloride 44 mg) tablets every 12 hours

    Use: management of acute pain in adults that is severe enough to require an opioid analgesic and for which alternative treatments are inadequate Use for the shortest duration consistent with individual patient treatment goals.

    Warnings

  • Get emergency help or call 911 right away if you take too much Seglentis (overdose). When you first start taking Seglentis, when your dose is changed, or if you take too much (overdose), serious or life-threatening breathing problems that can lead to death may occur. Talk to your healthcare provider about naloxone, a medicine for the emergency treatment of an opioid overdose.
  • Taking Seglentis with other opioid medicines, benzodiazepines, alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, decreased awareness, breathing problems, coma, and death.
  • Never give anyone else your Seglentis. They could die from taking it. Selling or giving away Seglentis is against the law.
  • Store Seglentis securely, out of sight and reach of children, and in a location not accessible by others, including visitors to the home.
  • Celecoxib can cause serious side effects, including:
  • Increased risk of a heart attack or stroke that can lead to death. This risk may happen early in treatment and may increase:
  • with increasing doses of NSAIDs
  • with longer use of NSAIDs

    • Do not take NSAIDs right before or after a heart surgery called a “coronary artery bypass graft” (CABG). Avoid taking NSAIDs after a recent heart attack, unless your healthcare provider tells you to. You may have an increased risk of another heart attack if you take NSAIDs after a recent heart attack.

  • Increased risk of bleeding, ulcers, and tears (perforation) of the esophagus (tube leading from the mouth to the stomach), stomach and intestines:
  • anytime during use
  • without warning symptoms
  • that may cause death

    • The risk of getting an ulcer or bleeding increases with:

  • past history of stomach ulcers, or stomach or intestinal bleeding with use of NSAIDs
  • taking medicines called “corticosteroids”, “antiplatelet drugs” “anticoagulants”, “SSRIs” or “SNRIs”
  • increasing doses of NSAIDs
  • longer use of NSAIDs
  • smoking
  • drinking alcohol
  • older age
  • poor health
  • advanced liver disease
  • bleeding problems

    • Important Information Guiding Use in Pediatric Patients:

  • Do not give Seglentis to a child younger than 12 years of age.
  • Do not give Seglentis to a child younger than 18 years of age after surgery to remove the tonsils and/or adenoids.
  • Avoid giving Seglentis to children between 12 to 18 years of age who have risk factors for breathing problems such as obstructive sleep apnea, obesity, or underlying lung problems.

    • What other drugs will affect Seglentis

    Many drugs can interact with Seglentis. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.

    Especially tell your doctor if you take:

  • antidepressants
  • antibiotics or antifungal medicines
  • medicines for HIV or hepatitis C
  • seizure medicines
  • blood thinners
  • aspirin
  • other NSAIDs
  • sedatives, muscle relaxers, or other drugs that make you drowsy
  • heart or blood pressure medication
  • other opioid painkillers
  • diuretics
  • medicine for allergies, asthma, blood pressure, motion sickness, irritable bowel, or overactive bladder
  • methotrexate
  • cyclosporine
  • steroid medicines

    • This list is not complete. Many other drugs may affect Celecoxib and tramadol.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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