Selegiline transdermal

Generic name: Selegiline (transdermal)
Brand names: Emsam
Dosage form: transdermal film, extended release (12 mg/24 hr; 6 mg/24 hr; 9 mg/24 hr)

Usage of Selegiline transdermal

Selegiline prevents the breakdown of chemicals in the brain that are often imbalanced in people with depression.

Selegiline transdermal is used to treat major depressive disorder in adults and adolescents who are at least 12 years old.

Selegiline may also be used for purposes not listed in this medication guide.

Selegiline transdermal side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Remove the skin patch and get emergency medical help if you have any of these signs of dangerously high blood pressure: sudden and severe headache, confusion, vision problems, chest pain, pounding in your neck or ears, sweating, vomiting, neck stiffness, fast or slow heartbeats, or dilated pupils.

Selegiline may cause serious side effects. Call your doctor at once if you have:

sudden numbness or weakness (especially on one side of the body);

problems with speech or balance;

manic episodes--racing thoughts, increased energy, unusual risk-taking behavior, extreme happiness, being irritable or talkative.

Remove the patch and seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common side effects of selegiline may include:

redness or itching where the patch is worn;

headache;

diarrhea, upset stomach, dry mouth;

sleep problems (insomnia);

rash; or

sinus pain or stuffy nose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Selegiline transdermal

You should not use selegiline if you are allergic to it, or if you have pheochromocytoma (tumor of the adrenal gland).

Some medicines can cause unwanted or dangerous effects when used with selegiline. Your doctor may need to change your treatment plan if you have used any of the following drugs within the past 2 to 5 weeks:

Carbamazepine;

Dextromethorphan (cough medicine);

Meperidine, methadone, Pentazocine, or tramadol; or

certain antidepressants--citalopram, clomipramine, Desvenlafaxine, duloxetine, fluoxetine, imipramine, milnacipran, paroxetine, Sertraline, venlafaxine, Cymbalta, Effexor, Savella, Pristiq, Prozac, Zoloft, and others.

To make sure selegiline is safe for you, tell your doctor if you have ever had:

heart disease, high blood pressure;

seizures or epilepsy; or

bipolar disorder (manic depression) or suicide attempt.

Some young people have thoughts about suicide when first taking an antidepressant. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.

It is not known whether selegiline will harm an unborn baby. However, you may have a relapse of depression if you stop using your antidepressant. Tell your doctor right away if you become pregnant. Do not start or stop selegiline during pregnancy without your doctor's advice.

It is not known whether selegiline passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine and for at least 5 days after your last dose.

Selegiline transdermal is not approved for use by anyone younger than 12 years old.

How to use Selegiline transdermal

Usual Adult Dose for Parkinson's Disease:

Oral capsule and tablet: 5 mg orally twice a day taken at breakfast and lunchMaximum dose: 10 mg orally per dayOral disintegrating tablet:-Initial dose: 1.25 mg orally once a day for at least 6 weeks -After 6 weeks, the dose may be increased to 2.5 mg orally once a day if neededMaintenance dose: 1.25 to 2.5 mg orally once a day before breakfastMaximum dose: 2.5 mg orally once a dayComments:-Two to 3 days after initiating therapy with this drug, an attempt may be made to reduce the dose of Levodopa-Carbidopa; typically a 10% to 30% reduction is needed; further reductions may be possible during continued concomitant use. -There is no evidence that this drug has beneficial effect in the absence of concurrent levodopa therapy. Use: As an adjunct in the management of Parkinson's disease in patients being treated with levodopa-carbidopa who exhibit deterioration in the quality of their response to this therapy.

Usual Adult Dose for Depression:

Transdermal System: Initial dose: 6 mg/24 hours patch applied topically once a day-Based on clinical judgement, doses may be increased in increments of 3 mg/24 hours at intervals of no less than 2 weeks Maintenance dose: 6 mg/24 hours to 12 mg/24 hours patch applied topically once a day Maximum dose: 12 mg/24 hours Comments:-Full antidepressant effect may be delayed.-Tyramine-rich food should be avoided beginning on the first day of therapy with a dose of 9 mg/24 hours or 12 mg/24 hours and continued to be avoided for 2 weeks after these doses are reduced to 6 mg/24 hours or less. Use: Treatment of major depressive disorder (MDD)

Warnings

You should not use selegiline if you have an adrenal gland tumor or if you are using certain other medicines. Many drugs can interact with selegiline, and some drugs should not be used together.

Some young people have thoughts about suicide when first using an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.

What other drugs will affect Selegiline transdermal

If you have been taking fluoxetine (Prozac, Sarafem), you must stop taking it for 5 weeks before you begin using selegiline transdermal.

Many drugs can interact with selegiline, and some drugs should not be used together. Tell your doctor about all your current medicines and any you start or stop using, especially:

Buspirone (Buspar);

any other antidepressant;

cough or cold medicine that contains a decongestant such as phenylephrine or pseudoEphedrine;

prescription or over-the-counter diet pills;

an herbal or dietary supplement that contains tyramine; or

stimulant medicine such as Adderall or other medicines to treat attention deficit hyperactivity disorder (ADHD).

This list is not complete and many other drugs can interact with selegiline. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

After you stop using selegiline, you may need to wait at least 2 weeks before you start using other medicines.

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