Selexipag
Brand names: Uptravi
Drug class:
Antineoplastic Agents , Antineoplastic Agents
Usage of Selexipag
Pulmonary Arterial Hypertension
Management of pulmonary arterial hypertension (PAH; WHO group 1) to delay disease progression and reduce the risk of hospitalization. Efficacy established principally in patients with WHO functional class II–III PAH (idiopathic, heritable, or associated with connective tissue disease or congenital heart disease with repaired shunts).
Treatment with selexipag alone or in combination with an endothelin receptor antagonist and/or a phosphodiesterase (PDE) type 5 inhibitor reduces risk of disease progression and hospitalization in patients with PAH, but has not been shown to reduce mortality.
Expert consensus guidelines from the American College of Chest Physicians (ACCP) recommend that all adult patients with symptomatic PAH be treated with established PAH-specific medications. Selection of drug therapy should be based on disease severity (WHO/NYHA class) in addition to comorbid conditions, concomitant medications, adverse effects, route of administration, costs, and patient preferences.
The ACCP guideline panel determined that there was insufficient evidence to make a recommendation either for or against the use of selexipag because of limitations in the clinical trial data.
Has been designated an orphan drug by FDA for treatment of PAH.
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How to use Selexipag
General
Patient Monitoring
Monitor patients for signs and symptoms of pulmonary edema.
Administration
Administer orally or by IV infusion. Parenteral preparation intended for use in patients who are temporarily unable to take oral therapy.
Oral Administration
Administer orally twice daily without regard to meals; tolerability may be improved when taken with food.
Do not split, chew, or crush tablets.
IV Administration
Administer by IV infusion twice daily. Use an infusion set made of DEHP-free polyvinyl chloride, natural latex rubber-free microbore tubing protected from light. Do not use a filter for administration.
Reconstitute and further dilute prior to administration.
ReconstitutionRemove carton from refrigerator and allow to stand for approximately 30–60 minutes to reach room temperature (20–25°C). Protect vial from light.
Reconstitute using a polypropylene syringe with 8.6 mL of 0.9% sodium chloride injection; slowly inject diluent into vial to obtain a concentration of 225 mcg/mL. Document date and time of first vial puncture.
DilutionDilute in glass containers only. Transfer 100 mL of 0.9% sodium chloride injection into empty sterile glass container. Withdraw required volume of reconstituted selexipag solution using a single polypropylene syringe and add to glass container containing 100 mL 0.9% sodium chloride injection to obtain desired final dose. Assign a 4-hour expiry from time of first vial puncture; wrap glass container completely with light protective cover.
Complete infusion within 4 hours from first vial puncture (including infusion time).
Rate of AdministrationAdminister diluted selexipag for injection by IV infusion over 80 minutes using an infusion set made of DEHP-free polyvinyl chloride, natural latex rubber-free microbore tubing protected from light. Do not use a filter for administration.
Once solution for infusion glass container is empty, continue infusion at the same rate with 0.9% sodium chloride injection to empty the remaining solution for infusion in the IV line, to ensure that the entire solution for infusion has been administered.
Dosage
Adults
PAH OralIndividualize dosage based on tolerability.
Initially, 200 mcg twice daily. Increase dosage in increments of 200 mcg twice daily (usually at weekly intervals) to the highest tolerated dose (maximum 1600 mcg twice daily).
Adverse effects tend to occur more frequently during dose titration phase and may be managed with analgesics, antidiarrheals, and antiemetics.
If a dose is missed, take as soon as it is remembered; if next dose is due within 6 hours, skip missed dose and take next dose at the regularly scheduled time.
IVAdminister at a dose that corresponds to the patient’s current oral dose (see Table 1).
Table 1: Dosage of IV Selexipag Based on Current Oral Selexipag Dosage.1Selexipag tablet dose (mcg) for twice daily dosing
Corresponding IV selexipag dose (mcg) for twice daily dosing
Reconstituted transfer volume (mL) for dilution
200
225
1
400
450
2
600
675
3
800
900
4
1000
1125
5
1200
1350
6
1400
1575
7
1600
1800
8
Dosage Modification for Co-administration of Moderate CYP2C8 InhibitorsReduce dosing interval of selexipag to once daily when co-administered with moderate CYP2C8 inhibitors (e.g., clopidogrel, deferasirox, and Teriflunomide).
Prescribing Limits
Adults
PAH OralMaximum 1600 mcg twice daily.
IVMaximum 1800 mcg twice daily.
Special Populations
Hepatic Impairment
Mild hepatic impairment (Child-Pugh class A): No dosage adjustment necessary.
Moderate hepatic impairment (Child-Pugh class B): Initially, 200 mcg tablet once daily; increase dosage in increments of 200 mcg once daily at weekly intervals as tolerated.
Severe hepatic impairment (Child-Pugh class C): Avoid use.
Renal Impairment
Patients with eGFR >15 mL/minute per 1.73 m2: No dosage adjustments necessary.
Patients with eGFR <15 mL/minute per 1.73 m2 or those undergoing dialysis: Not studied.
Geriatric Use
No specific dosage recommendations at this time.
Warnings
Contraindications
Warnings/Precautions
Pulmonary Edema with Pulmonary Veno-Occlusive Disease
Consider possibility of associated pulmonary veno-occlusive disease (PVOD) and discontinue selexipag if manifestations of pulmonary edema occur.
Specific Populations
PregnancyNo adequate and well-controlled studies in pregnant women. Selexipag did not affect embryofetal development and survival in animal studies.
LactationDistributed into milk in rats; not known whether distributed into human milk. Discontinue nursing or the drug.
Pediatric UseSafety and efficacy not established.
Geriatric UseNo overall differences in safety and efficacy observed between geriatric and younger patients; however, increased sensitivity in some older individuals cannot be ruled out.
Hepatic ImpairmentSystemic exposure to selexipag is increased in patients with mild hepatic impairment (Child-Pugh class A); systemic exposure to both drug and active metabolite are increased in patients with moderate hepatic impairment (Child-Pugh class B).
Not studied in patients with severe hepatic impairment (Child-Pugh class C); avoid use.
Renal ImpairmentSystemic exposure to selexipag is increased in patients with severe renal impairment (eGFR of 15–29 mL/minute per 1.73 m2).
Not studied in patients on dialysis or in those with eGFR <15 mL/minute per 1.73 m2.
Common Adverse Effects
Adverse effects (≥5% and more frequently than placebo): headache, diarrhea, jaw pain, nausea, myalgia, vomiting, pain in extremity, and flushing.
Infusion-site reactions (infusion site erythema/redness, pain and swelling) were reported with selexipag for injection.
What other drugs will affect Selexipag
Selexipag and its active metabolite are metabolized by CYP2C8 (principally) and CYP3A4. Selexipag and its active metabolite do not inhibit or induce CYP enzymes at clinically relevant concentrations nor do they inhibit hepatic or renal transport proteins.
Selexipag and its active metabolite are substrates of organic anion transport protein (OATP) 1B1 and 1B3. Selexipag is a substrate of P-glycoprotein (P-gp), and the active metabolite is a substrate of breast cancer resistance protein (BCRP).
Drugs Affecting Hepatic Microsomal Enzymes
Potent inhibitors of CYP2C8: Possible increased exposure to selexipag and its active metabolite; concomitant use contraindicated.
Moderate inhibitors of CYP2C8: Although not specifically evaluated, increased exposure to selexipag and its active metabolite is possible. Consider a less frequent dosing regimen (e.g., once daily) when initiating selexipag in patients receiving a moderate CYP2C8 inhibitor. Reduce dosage of selexipag when initiating a moderate CYP2C8 inhibitor.
Inducers of CYP2C8: Possible decreased exposure to active metabolite of selexipag.
Inhibitors of CYP3A4: Not expected to alter pharmacokinetics of selexipag and its active metabolite to a clinically important extent; dosage adjustment of selexipag does not appear to be necessary.
Drugs Affecting Transport Proteins
Inhibitors of OATP1B1, OATP1B3, and P-gp: Not expected to alter pharmacokinetics of selexipag and its active metabolite to a clinically important extent; dosage adjustment of selexipag does not appear to be necessary.
Specific Drugs
Drug
Interaction
Comments
Clopidogrel
Clopidogrel, a moderate inhibitor of CYP2C8, increased exposure to active metabolite of selexipag
Reduce dosing interval of selexipag to once daily
Deferasirox
Deferasirox, a moderate inhibitor of CYP2C8, may increase exposure to active metabolite of selexipag
Consider a less frequent dosing regimen of selexipag (e.g., once daily) when initiating the drug in patients already receiving deferasirox; reduce selexipag dosage when deferasirox is initiated in patients already receiving selexipag
Endothelin-receptor antagonists
No clinically relevant drug interaction observed
No dosage adjustment necessary
Gemfibrozil
Gemfibrozil, a strong inhibitor of CYP2C8, increased exposure to selexipag by twofold and its active metabolite by 11-fold
Concomitant use contraindicated
Lopinavir and ritonavir
Fixed combination of lopinavir and ritonavir (lopinavir/ritonavir): No clinically relevant pharmacokinetic interaction observed
No dosage adjustment necessary
PDE type 5 inhibitors
No clinically relevant drug interaction observed
No dosage adjustment necessary
Rifampin
May decrease exposure to active metabolite of selexipag
Increase dosage of selexipag (up to twofold) when used concomitantly with rifampin; reduce selexipag dosage when rifampin is discontinued
Teriflunomide
Teriflunomide, a moderate inhibitor of CYP2C8, may increase exposure to active metabolite of selexipag
Consider a less frequent dosing regimen of selexipag (e.g., once daily) when initiating the drug in patients already receiving teriflunomide; reduce selexipag dosage when teriflunomide is initiated in patients already receiving selexipag
Warfarin
No change in pharmacokinetics of warfarin or selexipag; no effect on INR
No dosage adjustment necessary
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