Selinexor
Generic name: Selinexor
Dosage form: oral tablet (20 mg; 40 mg; 50 mg; 60 mg)
Drug class:
Miscellaneous antineoplastics
Usage of Selinexor
Selinexor is used together with Bortezomib and/or Dexamethasone to treat multiple myeloma in adults.
Selinexor is also used in adults to treat certain types of diffuse large B-cell lymphoma.
Selinexor is given after other medications did not work or have stopped working.
Selinexor was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, some people responded to selinexor, but further studies are needed.
Selinexor may also be used for purposes not listed in this medication guide.
Selinexor side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Selinexor can cause serious or fatal side effects. Some side effects may not occur until you have been taking this medicine for several days or weeks.
Selinexor may cause serious side effects. Call your doctor at once if you have:
Your treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects of selinexor may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Selinexor
Tell your doctor if you have ever had:
You may need to have a negative pregnancy test before starting this treatment.
Both men and women using selinexor should use effective birth control to prevent pregnancy. Selinexor can harm an unborn baby if the mother or father is using this medicine.
Keep using birth control for at least 1 week after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using selinexor.
This medicine may affect fertility (ability to have children) in both men and women. However, it is important to use birth control to prevent pregnancy because selinexor can harm an unborn baby.
Do not breastfeed while using this medicine, and for at least 1 week after your last dose.
Not approved for use by anyone younger than 18 years old.
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How to use Selinexor
Usual Adult Dose for Multiple Myeloma:
IN COMBINATION WITH BORTEZOMIB AND DEXAMETHASONE (SVd):100 mg orally once weekly on Day 1 of each week until disease progression or unacceptable toxicity in combination with bortezomib 1.3 mg/m2 suBCutaneously once weekly on Day 1 of each week for 4 weeks followed by 1 week off; dexamethasone 20 mg orally twice weekly on Days 1 and 2 of each weekIN COMBINATION WITH DEXAMETHASONE:80 mg orally on Day 1 and 3 of each week until disease progression or unacceptable toxicity in combination with dexamethasone 20 mg orally with each dose of selinexor on Days 1 and 3 of each weekComments:-For additional information regarding the administration of bortezomib and dexamethasone, refer to its prescribing information.-Consider IV hydration for patients at risk of dehydration.-Provide prophylactic concomitant treatment with a 5-HT3 antagonist and/or other anti-nausea agents prior to and during therapy. Uses:-In combination with bortezomib and dexamethasone for patients with multiple myeloma who have received at least 1 prior therapy-In combination with dexamethasone for patients with relapsed or refractory multiple myeloma who have received at least 4 prior therapies and whose disease is refractory to at least 2 proteasome inhibitors, at least 2 immunomodulatory agents, and an anti-CD38 monoclonal antibody
Usual Adult Dose for Lymphoma:
60 mg orally on Day 1 and 3 of each week until disease progression or unacceptable toxicityComments:-Consider IV hydration for patients at risk of dehydration.-Provide prophylactic concomitant treatment with a 5-HT3 antagonist and/or other anti-nausea agents prior to and during therapy. Use: For the treatment of relapsed or refractory diffuse large B-cell lymphoma (DLBCL), not otherwise specified, including DLBCL arising from follicular lymphoma, after at least 2 lines of systemic therapy
Warnings
You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, flu symptoms, cough, mouth ulcers, or trouble breathing,
Selinexor can also cause low platelet counts in your blood. Tell your doctor right away if you have unusual bruising or bleeding.
What other drugs will affect Selinexor
Other drugs may affect selinexor, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.
Disclaimer
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The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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