Simcor

Generic name: Niacin And Simvastatin
Drug class: Antihyperlipidemic combinations

Usage of Simcor

Simcor contains a combination of niacin and simvastatin.

Simcor is used to lower cholesterol and triglycerides (types of fat) in the blood. Simcor is used along with diet to lower levels of total cholesterol, LDL "bad" cholesterol, and triglycerides and to increase HDL "good" cholesterol.

Niacin, also called nicotinic acid, is a B vitamin (vitamin B3). It occurs naturally in plants and animals, and is also added to many foods as a vitamin supplement. Niacin is also present in many multiple vitamins and nutritional supplements.

Simvastatin is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Simvastatin reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL).

Simcor side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Simcor: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Stop taking this medicine and call your doctor at once if you have:

confusion, memory problems;

swelling, weight gain, little or no urinating;

liver problems - nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or

high blood sugar - increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss.

Common Simcor side effects may include:

headache;

back pain;

nausea, diarrhea;

flushing (warmth, redness, or tingly feeling); or

mild itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Simcor

You should not take Simcor if you are allergic to niacin (Niaspan, Niacor, and others) or simvastatin (Zocor, Vytorin), or if you have:

liver disease;

stomach ulcer;

severe bleeding; or

if you are pregnant or breastfeeding.

Simvastatin can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. This condition may be more likely to occur in women and older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).

The following drugs can increase your risk of serious muscle problems if you take them together with simvastatin. These drugs should not be used while you are taking Simcor:

cyclosporine;

danazol;

gemfibrozil;

nefazodone;

an antibiotic - clarithromycin, erythromycin, telithromycin;

antifungal medicine - fluconazole, itraconazole, ketoconazole, posaconazole;

heart or blood pressure medicine - amiodarone, diltiazem, verapamil;

hepatitis C medications - Boceprevir, telaprevir; or

HIV or AIDS medication - atazanavir, cobicistat, darunavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, tipranavir.

Before you start taking Simcor, tell your doctor if you are already using any of these other medicines:

amlodipine; or

ranolazine.

To make sure Simcor is safe for you, tell your doctor if you have ever had:

liver or kidney disease;

diabetes;

gout;

a thyroid disorder; or

if you drink more than 2 alcoholic beverages daily;

or if you are switched to this medication from regular niacin, nicotinic acid, or nicotinamide (or vitamin supplements that contain niacin).

Simcor can harm an unborn baby or cause birth defects. Do not take Simcor if you are pregnant. Stop taking this medication and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking this medicine.

Niacin and simvastatin may pass into breast milk and could harm a nursing baby. Do not breastfeed while you are taking niacin and simvastatin.

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How to use Simcor

Usual Adult Dose for Hyperlipidemia:

Initial (for patients not currently on niacin extended-release and patients currently on niacin products other than niacin extended-release): 500 mg-20 mg orally once daily at bedtime with a low fat snack. Patients already taking simvastatin 20 to 40 mg who need additional management of their lipid levels may be started on a Simcor dose of 500 mg-40 mg once daily at bedtime. Maintenance (depending on patient tolerability and lipid levels): 1000 mg-20 mg to 2000 mg-40 mg once daily at bedtime with a low fat snack The dose of niacin extended-release should not be increased by more than 500 mg daily every 4 weeks. The efficacy and safety of doses of Simcor greater than 2000 mg-40 mg daily have not been studied and are therefore not recommended. If therapy is discontinued for an extended period of time (greater than 7 days), re-titration as tolerated is recommended.

Warnings

You should not take Simcor if you are allergic to niacin or simvastatin, or if you have liver disease, stomach ulcer, or severe bleeding.

Do not use Simcor if you are pregnant.

Do not breast-feed while using this medicine.

The following drugs should not be used while you are taking Simcor: cyclosporine, danazol, nefazodone, gemfibrozil; clarithromycin, erythromycin, telithromycin; fluconazole, itraconazole, ketoconazole, posaconazole; amiodarone, diltiazem, verapamil; boceprevir, telaprevir; atazanavir, cobicistat, darunavir, delavirdine, fosamprenavir, indinavir, nelfinavir, ritonavir, saquinavir, or tipranavir.

What other drugs will affect Simcor

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Simcor, especially:

fenofibric acid, fenofibrate; or

a blood thinner (warfarin, Coumadin, Jantoven).

This list is not complete and many other drugs can interact with niacin and simvastatin. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

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