Sinemet CR

Generic name: Carbidopa And Levodopa
Drug class: Dopaminergic antiparkinsonism agents

Usage of Sinemet CR

Sinemet CR is a combination medicine used to treat symptoms of Parkinson's disease, such as stiffness or tremors.

Sinemet CR is also used to treat Parkinson symptoms caused by carbon monoxide poisoning or manganese intoxication.

Sinemet CR may also be used for purposes not listed in this medication guide.

Sinemet CR side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Sinemet CR may cause serious side effects. Call your doctor at once if you have:

uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);

worsening of tremors (uncontrolled shaking);

severe or ongoing vomiting or diarrhea;

confusion, hallucinations, unusual changes in mood or behavior;

depression or suicidal thoughts; or

severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Some people taking Sinemet CR have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness.

You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking Sinemet CR. Talk with your doctor if this occurs.

You may notice that your sweat, urine, or saliva appears dark in color, such as red, brown, or black. This is not a harmful side effect, but it may cause staining of your clothes or bed sheets.

Common side effects of Sinemet CR may include:

jerky or twisting muscle movements;

headache, dizziness;

low blood pressure (feeling light-headed);

sleep problems, strange dreams;

dry mouth;

muscle contractions; or

nausea, vomiting, constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Sinemet CR

You should not use Sinemet CR if you are allergic to Carbidopa or levodopa, or if you have:

narrow-angle glaucoma.

Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, tranylcypromine, and others.

Tell your doctor if you have ever had:

heart disease, high blood pressure, or heart attack;

liver or kidney disease;

an endocrine (hormonal) disorder;

asthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder;

a stomach or intestinal ulcer;

open-angle glaucoma; or

depression, mental illness, or psychosis.

The disintegrating tablet may contain phenylalanine. Tell your doctor if you have phenylketonuria (PKU).

People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for.

Tell your doctor if you are pregnant or breastfeeding.

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How to use Sinemet CR

If you already take levodopa, you must stop taking it at least 12 hours before you start taking Sinemet CR.

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

Take this medicine at regular intervals, with or without food.

Swallow the capsule whole and do not crush, chew, break, or open it.

The tablet is sometimes broken in half to give the correct dose. Always swallow a whole or half tablet without chewing or crushing.

Place the orally disintegrating tablet in your mouth and allow it to dissolve, without chewing.

It may take up to several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. Tell your doctor if the effects of this medicine wear off quickly between doses.

If you use this medicine long-term, you may need frequent medical tests.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using Sinemet CR.

Do not stop using Sinemet CR suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using this medicine.

Store at room temperature away from moisture, heat, and light.

Warnings

Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine.

What other drugs will affect Sinemet CR

Other drugs may affect Sinemet CR, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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