Skyclarys
Generic name: Omaveloxolone
Dosage form: capsules, for oral use
Drug class:
Miscellaneous central nervous system agents
Usage of Skyclarys
Skyclarys is a prescription medicine used for the treatment of Friedreich's ataxia, a rare neuromuscular disorder that causes loss of strength and coordination, eventually resulting in patients requiring a wheelchair.
Skyclarys contains omaveloxolone, an activator of the nuclear factor-erythroid 2 related factor 2 (Nrf2) pathway, which is suppressed in people with Friedreich’s ataxia.
Skyclarys side effects
Skyclarys may cause serious side effects, including:
If your liver enzymes increase, your healthcare provider may change your dose during treatment, stop treatment for some time, or completely stop treatment.
If you have symptoms of fluid overload that is considered a side effect of Skyclarys, your healthcare provider may stop treatment.
The most common side effects include:
These are not all the possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800- FDA-1088.
Before taking Skyclarys
Before you start treatment, tell your healthcare provider about all of your medical conditions, including if you:
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How to use Skyclarys
Usual Dose for Friedreich's Ataxia:
150 mg (3 capsules) taken orally once daily
Use: treatment of Friedreich’s ataxia in adults and adolescents aged 16 years and older.
What other drugs will affect Skyclarys
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements such as St. John’s Wort.
Taking Skyclarys with other medicines can cause serious side effects.
Skyclarys may affect the way other medicines work, and other medicines may affect how Skyclarys works.
Skyclarys is known to interact with moderate or strong CYP3A4 inhibitors including:
Know the medicines you take. Keep a list of them to show to your healthcare provider and pharmacist when you get a new medicine.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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