Skyrizi

Generic name: Risankizumab
Drug class: Interleukin inhibitors

Usage of Skyrizi

Skyrizi (risankizumab) is a medication used to treat adults with certain types of plaque psoriasis, psoriatic arthritis, and Crohn’s disease, which are all autoimmune disorders. Skyrizi works by targeting a specific protein in the immune system called interleukin-23 (IL-23), which is responsible for causing inflammation in these conditions. Skyrizi helps reduce inflammation, which improves the symptoms of these conditions, by attaching to and blocking IL-23.

Skyrizi is a monoclonal antibody that belongs to a class of medications called interleukin-23 antagonists. Skyrizi is given as a suBCutaneous injection for plaque psoriasis and psoriatic arthritis, and for Crohn’s disease, it is given as an intravenous infusion for the induction period, then as a subcutaneous injection for maintenance dosing.

Skyrizi side effects

Get emergency medical help if you have signs of an allergic reaction to Skyrizi: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Infections

Call your doctor right away if you have signs of infection such as

fever, chills, sweating, body aches;

shortness of breath, cough, bloody mucus;

mouth sores, red or swollen gums;

stomach pain, diarrhea;

increased urination, burning when you urinate;

pale skin, easy bruising, unusual bleeding;

a fungal skin infection - skin sores different from psoriasis, rash or redness, blisters, itching, burning, cracking or peeling, changes in skin color; or

signs of tuberculosis: fever, cough, night sweats, loss of appetite, weight loss, and feeling very tired.

Further doses may be delayed until your infection clears up.

Liver side effects

Skyrizi may cause serious side effects, including liver problems in adults with Crohn’s disease.

Your healthcare provider will do blood tests to check your liver before, during, and up to 12 weeks of treatment. Your healthcare provider may stop treatment if you develop liver problems. Tell your healthcare provider right away if you notice any of the following symptoms:

unexplained rash;

nausea;

vomiting;

stomach (abdominal) pain;

tiredness (fatigue);

loss of appetite;

yellowing of the skin and eyes (jaundice);

dark urine.

Common Skyrizi side effects in adults treated for Crohn’s disease.

cold symptoms such as stuffy nose, sneezing, sore throat;

pain, redness, itching, bruising, swelling, warmth, bleeding, burning, or other skin irritation where the medicine was injected;

fever;

headache;

stomach (abdominal) pain;

back pain;

joint pain;

low red blood cells (anemia).

Common Skyrizi side effects in adults treated for plaque psoriasis and psoriatic arthritis.

cold symptoms such as stuffy nose, sneezing, sore throat;

headache;

feeling tired;

fungal skin infections;

injection site reactions.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Skyrizi

To make sure Skyrizi is safe for you, tell your doctor if you:

have an active or chronic infection.

have had or have been exposed to tuberculosis, or if you recently traveled. Some infections are more common in certain parts of the world, and you may have been exposed during travel.

have or have ever had liver disease, including cirrhosis, or any other medical conditions.

have recently received a vaccine or are scheduled for a booster dose. Make sure you are current on all vaccines before you start using this medicine.

This medicine is not approved for use by anyone younger than 18 years old.

Pregnancy

Tell your doctor if you are pregnant or planning to become pregnant. It is not known if this medicine can harm your unborn baby. If you are pregnant, your name may be listed on a pregnancy registry to track the effects of this medicine on the baby. The purpose of the pregnancy registry is to collect information about the health of you and your baby. Talk to your healthcare provider to enroll in this registry.

Breastfeeding

Before you start Skyrizi tell your doctor if you are breastfeeding or planning to breastfeed. It is not known if this medicine passes into your breast milk.

Relate drugs

How to use Skyrizi

Usual Adult Dose for Plaque Psoriasis:

Use: For the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy.

Dose: 150 mg subcutaneously at Week 0, Week 4, and every 12 weeks thereafter

Comments: Evaluate patients for tuberculosis (TB) infection prior to initiating this drug.

Usual Adult Dose for Psoriatic Arthritis

Use: For the treatment of active psoriatic arthritis in adults

Dose: 150 mg subcutaneously at Week 0, Week 4, and every 12 weeks thereafter

Comments: Evaluate patients for tuberculosis (TB) infection prior to initiating this drug.

Usual Adult Dose for Crohn's disease:

Use: For the treatment of moderately to severely active Crohn's disease in adults.

Induction dosage: 600 mg administered by intravenous infusion over at least one hour at Week 0, Week 4, and Week 8. Maintenance dosage: 360 mg administered by subcutaneous injection using the prefilled cartridge with on-body injector, at Week 12, and every 8 weeks thereafter.

Comments: Evaluate patients for tuberculosis (TB) infection prior to initiating this drug. Obtain liver enzymes and bilirubin levels prior to initiating treatment with this drug.

Warnings

Skyrizi affects your immune system and you may get infections more easily. Call your doctor right away if you have signs of infection such as: fever, chills, sweats, muscle aches, skin sores, stomach pain, diarrhea, burning when you urinate, weight loss, cough, shortness of breath, or a cough with red or pink mucus.

This medicine should not be used if you are allergic risankizumab-rzaa or any of the ingredients in this medicine. For a full list of ingredients click on this link Ingredients

What other drugs will affect Skyrizi

Other drugs may interact with risankizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Disclaimer

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