Sodium phosphate dibasic and sodium phosphate monobasic (Oral)

Generic name: Sodium Phosphate Dibasic And Sodium Phosphate Monobasic
Drug class: Laxatives

Usage of Sodium phosphate dibasic and sodium phosphate monobasic (Oral)

Sodium phosphate dibasic and sodium phosphate monobasic combination is used to clean or empty your bowels before an imaging procedure called colonoscopy. This medicine works by cleaning your colon and causing you to have diarrhea. This helps your doctor see the inside of your colon more clearly during the colonoscopy.

This medicine is available only with your doctor's prescription.

Sodium phosphate dibasic and sodium phosphate monobasic (Oral) side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Bloating

stomach pain

Incidence not known

Agitation

bloody or cloudy urine

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

confusion

cough

decrease in the frequency or amount of urine

decreased awareness or responsiveness

depression

difficult or labored breathing

difficult or painful urination

difficulty with swallowing

dizziness

fainting

fast, slow, or irregular heartbeat

headache

hives, itching, skin rash

hostility

increased blood pressure

increased thirst

irritability

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals

loss of appetite

loss of consciousness

lower back or side pain

muscle twitching

nausea

noisy breathing

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rapid weight gain

redness of the skin

seizures

severe sleepiness

sudden decrease in the amount of urine

swelling of the face, ankles, or hands

tightness in the chest

unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

vomiting

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Blurred vision

chest pain or discomfort

decreased frequency of urine

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

dry mouth

increase in heart rate

increased thirst

lightheadedness

loss of appetite

lower back or side pain

muscle cramps in the hands, arms, feet, legs, or face

muscle pain

pounding or rapid pulse

rapid breathing

restlessness

stomach cramps

sunken eyes

sweating

tremor

weakness

weight gain

wrinkled skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Sodium phosphate dibasic and sodium phosphate monobasic (Oral)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of OsmoPrep® tablets in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of OsmoPrep® tablets in the elderly. However, elderly patients may be more sensitive to the effects of OsmoPrep® tablets than younger adults, and are more likely to have age-related kidney problems, which may require caution for patients receiving this medicine.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Bepridil

Burosumab-twza

Cisapride

Dronedarone

Levoketoconazole

Mesoridazine

Pimozide

Piperaquine

Saquinavir

Sparfloxacin

Terfenadine

Thioridazine

Ziprasidone

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Adagrasib

Alfuzosin

Amiodarone

Amisulpride

Amitriptyline

Amoxapine

Anagrelide

Apomorphine

Aripiprazole

Aripiprazole Lauroxil

Arsenic Trioxide

Asenapine

Astemizole

Atazanavir

Azithromycin

Bedaquiline

Buprenorphine

Buserelin

Ceritinib

Chloroquine

Chlorpromazine

Ciprofloxacin

Citalopram

Clarithromycin

Clofazimine

Clomipramine

Clothiapine

Clozapine

Crizotinib

Dabrafenib

Dasatinib

Degarelix

Delamanid

Desipramine

Deslorelin

Deutetrabenazine

Dexmedetomidine

Disopyramide

Dofetilide

Dolasetron

Domperidone

Donepezil

Droperidol

Efavirenz

Encorafenib

Entrectinib

Erdafitinib

Erythromycin

Escitalopram

Etrasimod

Fexinidazole

Fingolimod

Flecainide

Fluconazole

Fluoxetine

Formoterol

Foscarnet

Fostemsavir

Gatifloxacin

Gemifloxacin

Gepirone

Glasdegib

Gonadorelin

Goserelin

Granisetron

Halofantrine

Haloperidol

Histrelin

Hydroxychloroquine

Hydroxyzine

Ibutilide

Iloperidone

Imipramine

Inotuzumab Ozogamicin

Ivabradine

Ivosidenib

Ketoconazole

Lapatinib

Lefamulin

Lenvatinib

Leuprolide

Levofloxacin

Lofexidine

Lopinavir

Lumefantrine

Macimorelin

Mefloquine

Methadone

Metronidazole

Mifepristone

Mirtazapine

Mobocertinib

Moxifloxacin

Nafarelin

Nilotinib

Norfloxacin

Nortriptyline

Octreotide

Ofloxacin

Olanzapine

Ondansetron

Osilodrostat

Osimertinib

Oxaliplatin

Ozanimod

Pacritinib

Paliperidone

Panobinostat

Paroxetine

Pasireotide

Pazopanib

Phenobarbital

Pimavanserin

Pitolisant

Ponesimod

Posaconazole

Primidone

Procainamide

Prochlorperazine

Promethazine

Propafenone

Protriptyline

Quetiapine

Quinidine

Quinine

Quizartinib

Ranolazine

Relugolix

Ribociclib

Selpercatinib

Sertraline

Sevoflurane

Siponimod

Solifenacin

Sorafenib

Sotalol

Sulpiride

Sunitinib

Tacrolimus

Telavancin

Telithromycin

Tetrabenazine

Trazodone

Triclabendazole

Trimipramine

Triptorelin

Vandetanib

Vardenafil

Vemurafenib

Vilanterol

Vinflunine

Voclosporin

Voriconazole

Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aluminum Carbonate, Basic

Aluminum Hydroxide

Aluminum Phosphate

Calcium acetate

Calcium carbonate

Calcium citrate

Dihydroxyaluminum Aminoacetate

Dihydroxyaluminum Sodium Carbonate

Magaldrate

Magnesium Carbonate

Magnesium Hydroxide

Magnesium Oxide

Magnesium Trisilicate

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Relate drugs

How to use Sodium phosphate dibasic and sodium phosphate monobasic (Oral)

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.

Take each dose (4 tablets) with 8 ounces of clear liquids. Examples of clear liquids include: water, flavored water, clear broth, herbal tea, black tea, coffee, clear soda, gelatin, popsicles, lemonade (no pulp), ginger ale, white grape juice, or apple juice. Do not eat or drink alcohol, milk, anything colored purple or red, or any foods that have pulp.

Eat or drink only clear liquids after 12:00 PM (noon) on the day before and until after your colonoscopy. Do not eat solid food.

Drink as much extra liquid as you can before, during, and after taking this medicine. This will help replace the fluids you are losing with your bowel movements. This will also keep your kidneys working well and help soften your bowel movements, making them easier to pass.

Do not take any oral medicines within 1 hour before or after each dose of OsmoPrep®.

Do not take this medicine if you have already used it in the last 7 days. Your doctor will tell you if you need to use this medicine again.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets):

For cleansing of the colon:

Adults—

Evening before the colonoscopy: Four tablets with 8 ounces (oz.) of clear liquids every 15 minutes (for a total of 20 tablets).

Day of colonoscopy (starting 3 to 5 hours before the procedure): Four tablets with 8 oz. of clear liquids every 15 minutes (for a total of 12 tablets).

Children—Use and dose must be determined by your doctor.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Warnings

It is very important that your doctor check your progress after taking this medicine. This will allow your doctor to see if the medicine is working properly. Blood and urine tests and an electrocardiogram (ECG) may be needed to check for unwanted effects.

Do not take this medicine together with other laxatives or enemas containing sodium phosphate. Doing so may lead to serious unwanted effects.

This medicine may cause serious kidney problems. These are more likely to occur if you are over 55 years of age, dehydrated, have low blood volume, and are taking medicines that could be hard on your kidneys (eg, diuretics or water pills, certain blood pressure medicines, NSAID pain or arthritis medicine). Check with your doctor right away if you have bloody urine, a decrease in the amount or frequency of urine, lower back or side pain, trouble breathing, weight gain, or swelling of the face, fingers, and lower legs.

Taking more than one dose of over-the-counter (OTC) sodium phosphate medicine in 24 hours may cause serious kidney and heart problems. Check with your doctor if you have the following symptoms: confusion, decreased urination, dizziness, dry mouth, fainting, increase in heart rate, rapid breathing, or unusual tiredness or weakness.

Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you had a heart rhythm problem, such as QT prolongation.

This medicine may cause serious allergic reactions, including anaphylaxis and angioedema, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after using this medicine.

Call your doctor right away if you have any unusual symptoms that concern you, such as bloating, abdominal or stomach pain, seizures, nausea, vomiting, or headache.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

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