Sotorasib

Generic name: Sotorasib
Brand names: Lumakras
Dosage form: oral tablet (120 mg; 320 mg)
Drug class: Miscellaneous antineoplastics

Usage of Sotorasib

Sotorasib is used in adults to treat non-small cell lung cancer who have already been treated with at least one other cancer medicine.

Sotorasib is given when the cancer has progressed or has spread to other parts of the body or when surgery is not an option.

Your doctor will make sure you have the correct tumor type to be treated with sotorasib.

Sotorasib may also be used for purposes not listed in this medication guide.

Sotorasib side effects

Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.

Sotorasib may cause breathing problems that could lead to death. Get emergency medical help if you have new or worsening fever, cough, or shortness of breath.

Sotorasib may cause serious side effects. Call your doctor at once if you have:

severe ongoing nausea, vomiting, or diarrhea;

unusual bleeding--bruising, any bleeding that will not stop; or

liver problems--loss of appetite, stomach pain (upper right side), tiredness, itching, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.

Common side effects of sotorasib may include:

nausea, diarrhea;

cough;

liver problems;

muscle, joint, or bone pain;

tiredness; or

abnormal blood tests.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Sotorasib

Tell your doctor if you have ever had:

liver disease; or

lung or breathing problems other than lung cancer.

It is not known if sotorasib will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Do not breastfeed while using sotorasib, and for at least 1 week after your last dose.

Relate drugs

How to use Sotorasib

Usual Adult Dose for Non-Small Cell Lung Cancer:

960 mg orally once a dayDuration of therapy: Until disease progression or unacceptable toxicityComments:-This indication is approved under accelerated approval based on overall response rate and duration of response; continued approval may depend on verification and description of clinical benefit in confirmatory trial(s).Use: For the treatment of patients with KRAS G12C-mutated locally advanced or metastatic non-small cell lung cancer (NSCLC), as determined by an FDA-approved test, who have received at least 1 prior systemic therapy

Warnings

Use only as directed. Tell your doctor if you use other medicines or have other medical conditions or allergies.

What other drugs will affect Sotorasib

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Avoid taking an antacid, such as:

cimetidine, famotidine, nizatidine, ranitidine, Pepcid, Tagamet, Zantac; or

dexlansoprazole, esomeprazole, lansoprazole, omeprazole, pantoprazole, rabeprazole, Nexium, Prevacid, Prilosec, Protonix, and others.

Other drugs may affect sotorasib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

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