Sotret

Generic name: Isotretinoin (oral)

Usage of Sotret

Sotret is a form of vitamin A that is used to treat severe nodular acne that has not responded to other treatments, including antibiotics.

Sotret is available only from a certified pharmacy under a special program called iPLEDGE.

Sotret may also be used for purposes not listed in this medication guide.

Sotret side effects

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Sotret may cause serious side effects. Stop using Sotret and call your doctor at once if you have:

problems with your vision or hearing;

muscle or joint pain, bone pain, back pain;

increased thirst, increased urination;

hallucinations, (see or hearing things that are not real);

symptoms of depression--unusual mood changes, crying spells, feelings of low self-worth, loss of interest in things you once enjoyed, new sleep problems, thoughts about hurting yourself;

signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes);

severe stomach problems--severe stomach or chest pain, pain when swallowing, heartburn, diarrhea, rectal bleeding, bloody or tarry stools; or

increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes.

Common side effects of Sotret may include:

dryness of your skin, lips, eyes, or nose (you may have nosebleeds);

vision problems;

headache, back pain, joint pain, muscle problems;

skin reactions; or

cold symptoms such as stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Before taking Sotret

Sotret can cause miscarriage, premature birth, severe birth defects, or death of a baby if the mother takes this medicine at the time of conception or during pregnancy. Even one dose of isotretinoin can cause major birth defects of the baby's ears, eyes, face, skull, heart, and brain. Never use this medicine if you are pregnant or able to become pregnant.

For Women: Unless you have had your uterus and ovaries removed (total hysterectomy with oophorectomy) or have been in menopause for at least 12 months in a row, you are considered to be able to get pregnant. You must have 2 negative pregnancy tests before you start taking Sotret, before each prescription is refilled, right after you take your last dose of isotretinoin, and again 30 days later. All pregnancy testing is required by the iPLEDGE program.

You must agree in writing to use two specific forms of birth control beginning 30 days before you start taking Sotret and ending 30 days after your last dose. Both a primary and a secondary form of birth control must be used together.

Primary forms of birth control include:

tubal ligation (tubes tied);

vasectomy of the male sexual partner;

an IUD (intrauterine device);

estrogen-containing birth control pills (not mini-pills); and

hormonal birth control patches, implants, injections, or vaginal ring.

Secondary forms of birth control include:

a male latex condom with or without spermicide;

a diaphragm plus a spermicide;

a cervical cap plus a spermicide; and

a vaginal sponge containing a spermicide.

Stop using Sotret and call your doctor at once if you have unprotected sex, if you quit using birth control, if your period is late, or if you think you might be pregnant. If you get pregnant while taking this medicine, call the iPLEDGE pregnancy registry at 1-866-495-0654.

Not having sexual intercourse (abstinence) is the most effective method of preventing pregnancy.

You should not use Sotret if you are allergic to it.

Tell your doctor if you have ever had:

depression or mental illness;

asthma;

liver disease;

diabetes;

heart disease or high cholesterol;

osteoporosis or low bone mineral density;

an eating disorder such as anorexia;

a food or drug allergy; or

an intestinal disorder such as inflammatory bowel disease or ulcerative colitis.

Do not breastfeed.

Not approved for use by anyone younger than 12 years old.

How to use Sotret

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Each prescription of isotretinoin must be filled within 7 days of the date it was written by your doctor. You will receive no more than a 30-day supply of isotretinoin at one time.

Always take Sotret with a full glass of water. Do not chew or suck on the capsule. Swallow it whole.

Follow all directions about taking Sotret with or without food.

Use Sotret for the full prescribed length of time. Your acne may seem to get worse at first, but should then begin to improve.

You may need frequent blood tests.

Never share this medicine with another person, even if they have the same symptoms you have.

Store at room temperature away from moisture, heat, and light.

Warnings

Sotret in just a single dose can cause severe birth defects or death of a baby. Never use Sotret if you are pregnant or able to become pregnant.

You must have a negative pregnancy test before taking Sotret. You will also be required to use two forms of birth control to prevent pregnancy while taking this medicine. Stop using this medicine and call your doctor at once if you think you might be pregnant.

What other drugs will affect Sotret

Tell your doctor about all your other medicines, especially:

phenytoin;

St. John's wort (may make birth control pills less effective);

vitamin or mineral supplements;

progestin-only birth control pills (mini-pills, may not work as well when taken with Sotret);

steroid medicine; or

a tetracycline antibiotic, including doxycycline or minocycline.

This list is not complete. Other drugs may affect Sotret, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.