Spesolimab-sbzo

Generic name: Spesolimab-sbzo
Drug class: Interleukin inhibitors

Usage of Spesolimab-sbzo

Spesolimab-sbzo injection is used to treat generalized pustular psoriasis (GPP) flares. GPP is a long-term skin disease that has flares (painful, pus-filled blisters over large areas of the body) which appear suddenly.

This medicine is to be given only by or under the direct supervision of your doctor.

Spesolimab-sbzo side effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Bladder pain

bloody or cloudy urine

difficult, burning, or painful urination

frequent urge to urinate

large, flat, blue, or purplish patches in the skin

lower back or side pain

Less common

Blistering, crusting, irritation, itching, or reddening of the skin

bruising at the injection site

body aches or pain

chest pain

chills

cough

coughing or spitting up blood

ear congestion

fever

headache

itching of the vagina or genitals

loss of voice

muscle aches

night sweats

sneezing

sore throat

stuffy or runny nose

sudden high fever or low-grade fever for months

swelling

thick, white vaginal discharge with mild or no odor

trouble breathing

unusual tiredness or weakness

Incidence not known

Black, tarry stools

bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

inability to move the arms and legs

painful or difficult urination

sores, ulcers, or white spots on the lips or in the mouth

sudden numbness and weakness in the arms and legs

swollen glands

unusual bleeding or bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Change in hearing

diarrhea

earache

ear drainage

itching ears

lack or loss of strength

nausea

vomiting

Less common

Hives, itching, or skin rash

swelling of the eye

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Before taking Spesolimab-sbzo

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of spesolimab-sbzo injection in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies on the relationship of age to the effects of spesolimab-sbzo injection have not been performed in the geriatric population.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Adenovirus Vaccine, Live

Bacillus of Calmette and Guerin Vaccine, Live

Cholera Vaccine, Live

Dengue Tetravalent Vaccine, Live

Ebola Zaire Vaccine, Live

Influenza Virus Vaccine, Live

Measles Virus Vaccine, Live

Mumps Virus Vaccine, Live

Poliovirus Vaccine, Live

Rotavirus Vaccine, Live

Rubella Virus Vaccine, Live

Smallpox Monkeypox Vaccine, Live Non-Replicating

Smallpox Vaccine

Typhoid Vaccine, Live

Varicella Virus Vaccine, Live

Yellow Fever Vaccine

Zoster Vaccine, Live

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Relate drugs

How to use Spesolimab-sbzo

A doctor or other trained health professional will give you this medicine in a medical facility. It is given through a needle that is placed into one of your veins. It must be given slowly, so the needle will have to remain in place for at least 90 minutes.

This medicine comes with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have questions.

Warnings

It is very important that your doctor check your or your child's progress at regular visits to make sure that this medicine is working properly. Blood tests may be needed to check for unwanted effects.

Check with your doctor right away if you have a fever, chills, cough, flu-like symptoms, or unusual tiredness or weakness. These may be signs that you have an infection.

This medicine may cause serious allergic reaction, including anaphylaxis, which can be life-threatening and requires immediate medical attention. Check with your doctor right away if you have chest tightness, cough, difficulty swallowing, dizziness, fast heartbeat, hives, itching, or skin rash, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, trouble breathing, or unusual tiredness or weakness.

This medicine may cause infusion-related reactions, which can be life-threatening and require immediate medical attention. Tell your doctor right away if you start to have a fever, chills or shaking, dizziness, trouble breathing, itching or rash, lightheadedness or fainting after receiving this medicine.

Serious skin reaction, including drug reaction with eosinophilia and systemic symptoms (DRESS) can occur with this medicine. Check with your doctor right away if you have black, tarry stools, chest pain, chills, cough, fever, painful or difficult urination, sore throat, sores, ulcers, or white spots on the lips or in the mouth, swollen glands, unusual bleeding or bruising, or unusual tiredness or weakness.

While you are being treated with spesolimab-sbzo, do not have any immunizations (vaccines) without your doctor's approval. Live virus vaccines should not be given with spesolimab-sbzo.

Disclaimer

Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.