Steglujan

Generic name: Ertugliflozin And Sitagliptin
Drug class: Antidiabetic combinations

Usage of Steglujan

Steglujan contains a combination of ertugliflozin and sitagliptin. Ertugliflozin and sitagliptin help control blood sugar levels. Ertugliflozin works by helping the kidneys get rid of glucose from your bloodstream. Sitagliptin works by regulating the levels of insulin your body produces after eating.

Steglujan is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.

Steglujan is not for treating type 1 diabetes.

Steglujan side effects

Get emergency medical help if you have signs of an allergic reaction to Steglujan (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical attention right away if you have signs of a rare but serious genital infection (penis or vagina): burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, not feeling well. These symptoms may get worse quickly.

Call your doctor at once if you have:

  • severe autoimmune reaction - itching, blisters, breakdown of the outer layer of skin;
  • new pain, tenderness, sores, ulcers, or infections in your legs or feet;
  • severe or ongoing pain in your joints;
  • little or no urination;
  • ketoacidosis (too much acid in the blood) - nausea, vomiting, stomach pain, confusion, unusual drowsiness, or trouble breathing;
  • dehydration symptoms - dizziness, weakness, feeling light-headed (like you might pass out);
  • signs of a bladder infection - pain or burning when you urinate, increased urination, blood in your urine, fever, pain in your pelvis or back;
  • symptoms of heart failure - shortness of breath (even while lying down), swelling in your legs or feet, rapid weight gain; or
  • symptoms of pancreatitis - severe pain in your upper stomach spreading to your back, with or without nausea and vomiting.
  • Some side effects may be more likely to occur in older adults.

    Common Steglujan side effects may include:

  • urinating more than usual;
  • upset stomach, diarrhea;
  • headache; or
  • cold symptoms such as stuffy nose, sneezing, sore throat.
  • This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Before taking Steglujan

    You should not use Steglujan if you are allergic to ertugliflozin o sitagliptin, or if you have:

  • severe kidney problems, end stage renal disease, or if you are on dialysis.
  • To make sure Steglujan is safe for you, tell your doctor if you have ever had:

  • diabetic ketoacidosis;
  • liver or kidney disease;
  • a bladder infection or urination problems;
  • problems with your pancreas, including surgery;
  • a diabetic foot ulcer or amputation;
  • heart problems, high or low blood pressure;
  • blood circulation problems, especially in your legs;
  • nerve damage in your legs;
  • gallstones;
  • high triglycerides (a type of fat in blood);
  • alcoholism;
  • type 1 diabetes; or
  • if you are eating less, there is a change in your diet, or you are on a low salt diet.
  • Follow your doctor's instructions about using Steglujan if you are pregnant. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester.

    You should not use Steglujan during the second or third trimester of pregnancy.

    You should not breastfeed while using this medicine.

    Steglujan is not approved for use by anyone younger than 18 years old.

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    How to use Steglujan

    Usual Adult Dose for Diabetes Type 2:

    Initial dose: 1 tablet (ertugliflozin 5 mg/sitagliptin 100 mg) orally once a day -For patients tolerating therapy and requiring additional glycemic control, may increase to 1 tablet (ertugliflozin 15 mg/sitagliptin 100 mg) orally once a day Maximum dose: ertugliflozin 15 mg/sitagliptin 100 mg per day For patients already receiving ertugliflozin: Switch to combination product with same ertugliflozin dose Comments: -Volume depletion should be corrected prior to initiating therapy. -This drug is not recommended for patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis. -This drug has not been studied in patients with a history of pancreatitis; it is not known whether this may increase the risk of developing pancreatitis during therapy. Use: An adjunct to diet and exercise to improve glycemic control in adults with Type 2 diabetes mellitus when treatment with both Steglujan is appropriate.

    Warnings

    You should not use Steglujan if you have severe kidney disease, if you are on dialysis, or if you have diabetic ketoacidosis.

    This medicine can make you dehydrated, which could cause you to feel weak or dizzy (especially when you stand up).

    Stop taking Steglujan and call your doctor right away if you have symptoms of pancreatitis: severe pain in your upper stomach spreading to your back, with or without nausea and vomiting.

    In rare cases, this medicine can cause serious infections in the penis or vagina. Get medical help right away if you have burning, itching, odor, discharge, pain, tenderness, redness or swelling of the genital or rectal area, fever, or if you don't feel well.

    What other drugs will affect Steglujan

    When you start or stop taking Steglujan, your doctor may need to adjust the doses of any other diabetes medicines you use on a regular basis.

    Other drugs may interact with ertugliflozin and sitagliptin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

    Disclaimer

    Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.

    The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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