Suflave
Generic name: Polyethylene Glycol 3350, Sodium Sulfate, Potassium Chloride, Magnesium Sulfate, And Sodium Chloride
Dosage form: powder for reconstitution
Drug class:
Laxatives
Usage of Suflave
Suflave is a combination, osmotic prescription laxative that may be used to cleanse the bowel in preparation for colonoscopy in adults. Suflave contains polyethylene glycol 3350, sodium sulfate, potassium chloride, magnesium sulfate, and sodium chloride, and is supplied as a powder that is mixed with a low volume of water before consuming. It tastes like a lemon-lime sports drink.
Colonoscopy is the most common detection method for colorectal cancer and successful screening is dependent upon adequate cleansing of the colon. Many of the available bowel preparation products require the consumption of large volumes of poor-tasting solutions, which can result in low patient compliance. The palatability of Suflave has been shown to improve compliance in clinical trials.
Suflave works by osmosis, drawing water into the bowel, increasing the volume, and reducing the consistency of the stools, making them loose and easily cleared. It is taken as a split-dose regimen over two days.
Suflave was approved on June 15, 2023.
Suflave side effects
Suflave can cause serious side effects, including serious loss of body fluid (dehydration) and changes in blood salts (electrolytes) in your blood. These changes can cause abnormal heartbeats that can cause death, seizures, and kidney problems.
Tell your healthcare provider right away if you have any of the following symptoms:
Get medical help right away if you have any signs and symptoms of a serious allergic reaction while taking Suflave including difficulty breathing o itching, swelling of the face, lips, tongue, and throat, raised red patches on your skin (hives), or a skin rash.
The most common side effects of Suflave include:
These are not all the possible side effects of Suflave. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800- FDA-1088.
Before taking Suflave
Do not take Suflave if you have:
Tell your healthcare provider about all of your medical conditions, including:
It is not known if Suflave will harm an unborn baby. Talk to your healthcare provider if you are pregnant or planning to become pregnant.
It is not known if Suflave passes into breast milk. You and your healthcare provider should decide if you should breastfeed while taking Suflave.
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How to use Suflave
It is recommended to take two doses of Suflave for complete preparation of the bowel for colonoscopy.
One dose of Suflave is equal to one bottle plus one flavor-enhancing packet.
Day 1, Dose 1: The evening before the colonoscopy
Day 2, Dose 2: Morning of the Colonoscopy (5 to 8 hours before the colonoscopy and no sooner than 4 hours from starting Dose 1)
Warnings
There is a risk of fluid and electrolyte abnormalities with Suflave and you should follow the instructions on the packet exactly as directed, including drinking additional water. Your doctor may conduct laboratory tests before starting Suflave to check your electrolyte levels. Tell your doctor about any medications, supplements, and herbal remedies that you take.
Pre-dose and post-colonoscopy ECGs may be needed for patients at increased risk of heart problems.
Should be used with caution in patients with cardiac arrhythmias, patients who have seizures, and patients with renal impairment or those who are taking concomitant medications that affect renal function. There is a potential for ulcerations in patients with known or suspected inflammatory bowel disease. People at risk for aspiration should be observed during administration.
What other drugs will affect Suflave
Tell your doctor about all your other medicines, including prescription and over-the-counter medicines, vitamins, and herbal supplements, especially:
Do not take other laxatives while taking Suflave. For patients who have trouble swallowing, do not mix Suflave with starch-based thickeners.
Take the following medicines at least 2 hours before starting each dose of Suflave and not for at least 6 hours after taking each dose:
Medicines taken by mouth may not be absorbed properly when taken within 1 hour before the start of each dose of Suflave.
This list is not complete. Other drugs may interact with Suflave, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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