Sugammadex
Generic name: Sugammadex
Brand names: Bridion
Dosage form: intravenous solution (100 mg/mL)
Drug class:
Miscellaneous central nervous system agents
Usage of Sugammadex
Sugammadex reverses the effects of certain medications that are given during surgical procedures to relax your muscles.
Sugammadex is used at the end of surgery, to help restore muscle function that has been blocked during surgery by the other medicines.
Sugammadex may also be used for purposes not listed in this medication guide.
Sugammadex side effects
Get emergency medical help if you have signs of an allergic reaction: hives, skin rash or redness; difficult breathing; swelling of your face, lips, tongue, or throat.
Tell your caregivers right away if you have:
Common side effects of sugammadex may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Before taking Sugammadex
You should not use sugammadex if you are allergic to it.
To make sure sugammadex is safe for you, tell your doctor if you have:
It is not known whether sugammadex will harm an unborn baby. Tell your doctor if you are pregnant.
Sugammadex can make hormonal birth control less effective. For at least 7 days after you receive sugammadex, use a non-hormonal back-up birth control (condom or diaphragm with spermicide) to prevent pregnancy. Hormonal contraception (birth control pills, injections, implants, skin patches, and vaginal rings) may not be effective enough to prevent pregnancy during this time.
It is not known whether sugammadex passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
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How to use Sugammadex
Usual Adult Dose for Reversal of Nondepolarizing Muscle Relaxants:
Routine reversal (rocuronium or vecuronium):4 mg/kg IV once if recovery has reached at least 1 to 2 posttetanic counts (PTC) and no twitch responses to train-of-four (TOF) stimulation2 mg/kg IV once if recovery has reached reappearance of second twitch response to TOF stimulationImmediate reversal (rocuronium only):16 mg/kg IV onceComments: -Dosing is based on actual body weight; the recommended dose does not depend on the anesthetic regimen. -Satisfactory recovery should be determined by skeletal muscle tone assessments and respiratory measurements in addition to the response to peripheral nerve stimulation. -The efficacy of the 16 mg/kg dose following vecuronium-induced neuromuscular blockade has not been studied. Uses: For the reversal of different levels of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide in adults undergoing surgery.
Warnings
Before you receive sugammadex, tell your doctor about all your medical conditions or allergies, and all the medicines you are using. Also make sure your doctor knows if you are pregnant or breast-feeding.
What other drugs will affect Sugammadex
Tell your doctor about all your current medicines, especially:
Other drugs may interact with sugammadex, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Disclaimer
Every effort has been made to ensure that the information provided by Drugslib.com is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Drugslib.com information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Drugslib.com does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Drugslib.com's drug information does not endorse drugs, diagnose patients or recommend therapy. Drugslib.com's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners.
The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Drugslib.com does not assume any responsibility for any aspect of healthcare administered with the aid of information Drugslib.com provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
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